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JCI early table of contents for May 8, 2012
Date:5/8/2012
tural Killer T cells (NKTs) detect tumors and what tumors do to neutralize NKTs. Using a mouse model system, they found specialized cells in tumors known as tumor-associated macrophages secretes molecules that first attract NKTs, but then inhibit NKT cell function and viability. They further demonstrated that increasing expression of a gene called Il15 in NKTs enhanced the activity of NKTs and reduced the spread of cancer in mice. Their findings reveal how tumors can trap and evade the body's immune cells and suggest that the development of therapies that increase IL15 in NKTs merits further exploration.
TITLE:
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity
AUTHOR CONTACT:
Leonid Metelitsa
Baylor College of Medicine, Houston, TX, USA
Phone: 832-824-4395; E-mail: lsmeteli@txch.org
View this article at: http://www.jci.org/articles/view/59535?key=d4bb63659b4c9888cd11
ONCOLOGY
NUPR1 regulates pancreatic cancer development in mice
Pancreatic cancer is fourth most deadly cancer type worldwide. Patients typically have very few symptoms at early stages, frequently leading to detection at late, advanced stages with a poor prognosis. At the cellular level, pancreatic cancer cells show a remarkable resistance to cellular stress, which may account for such high resistance to treatment. Dr. Juan Lucio Iovanna and colleagues at the Mayo Clinic in Rochester, Minnesota wanted to better understand the molecular basis for this resistance to cellular stress. The Iovanna team specifically examined the role of Nuclear protein 1 (NUPR1), which is elevated in pancreatic cancer. Using a mouse model of pancreatic cancer, they found that loss of NUPR1 reduces the appearance of cancerous lesions and triggers
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