Navigation Links
JCI early table of contents for May 15, 2013
Date:5/15/2013

Hot on the TRAIL of graft vs. host disease

For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD). In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. Immune cells engineered to express higher levels of TRAIL killed the cells that cause GVHD and increased anti-tumor activity. In an accompanying commentary, Nelson Chao suggests that new therapeutics may take advantage of TRAIL-expressing cells to promote an anti-tumor response without putting patients at risk for GVHD.

TITLE: Fratricidal TRAIL+T cells suppress GVHD and augment anti-tumor activity after bone marrow transplantation

AUTHOR CONTACT:
Arnab Ghosh
Memorial Sloan-Kettering Cancer Center, New York, , USA
Phone: 646-888-2317; E-mail: ghosha1@mskcc.org

View this article at: http://www.jci.org/articles/view/66301?key=66e50de3cd0d7e99a4d8

ACCOMPANYING COMMENTARY

TITLE: Blazing a new TRAIL in hematopoietic cell transplantation

AUTHOR CONTACT:
Nelson J. Chao
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1011; Fax: 919-668-1091; E-mail: chao0002@mc.duke.edu

View this article at: http://www.jci.org/articles/view/69909?key=43f0101604c8f6bb12da

Researchers identify signals that direct the immune system to reject a transplanted organ

Organ transplant rejection occurs when the transplant recipient's immune system identifies the transplanted organ as foreign tissue and attacks it. It was previously thought that T cells, the immune cells that mediate rejection, must first be activated by molecules known as chemokines in order to migrate to the transplanted organ. In this issue of the Journal of Clinical Investigation, Fadi Lakkis and colleagues at the University of Pittsburgh used mice to demonstrate that chemokine stimulation of T cells is not required for migration. Instead, these cells must come into contact with immune-stimulating proteins (antigens) that are specifically expressed by the transplanted organ. In an accompanying commentary, Terry Strom discusses how these findings could have important implications for the design of novel anti-rejection therapeutics.

TITLE: Cognate antigen directs CD8+ T cell migration to vascularized transplants

AUTHOR CONTACT:
Fadi G. Lakkis
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
Phone: 412 383-5774; Fax: 412-383-9990; E-mail: lakkisf@upmc.edu

View this article at: http://www.jci.org/articles/view/66722?key=5debbc8dd29fc8e22b12

ACCOMPANYING COMMENTARY

TITLE: Transplant rejection and paradigms lost

AUTHOR CONTACT:
Terry Strom
Beth Israel Deaconess Medical Center, Boston, MA, USA
Phone: 1-617-735-2880; Fax: 1 617 667-0923; E-mail: tstrom@bidmc.harvard.edu

View this article at: http://www.jci.org/articles/view/69385?key=ee127335912183bcc713

ALSO IN THIS ISSUE

TITLE: Safe TNF-based antitumor therapy following p55TNFR reduction in intestinal epithelium

AUTHOR CONTACT:
George Kollias
Biomedical Sciences Research Centre (BSRC) "Alexander FLEMING", Institute o, Vari, GRC
Phone: 00302109656507; E-mail: kollias@fleming.gr

View this article at: http://www.jci.org/articles/view/65624?key=95dcd1ab2462f49889fd

TITLE: Lamin B1 mediates cell-autonomous neuropathology in a leukodystrophy mouse model

AUTHOR CONTACT:
Ying-Hui Fu
University of California San Francisco, San Francisco, CA, USA
Phone: 415-502-5614; E-mail: Ying-hui.fu@ucsf.edu

View this article at: http://www.jci.org/articles/view/66737?key=16236a3ef2fb14130105

TITLE: PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells

AUTHOR CONTACT:
Rafi Ahmed
Emory University, Atlanta, GA, USA
Phone: 404-727-3571; E-mail: rahmed@emory.edu

View this article at: http://www.jci.org/articles/view/67008?key=331ea19f479943e34a83

TITLE: The genomic landscape of small intestine neuroendocrine tumors

AUTHOR CONTACT:
Andreas Beutler
Mayo Clinic Rochester, Rochester, MN, USA
Phone: 507 2848009; E-mail: beutler.andreas@mayo.edu

View this article at: http://www.jci.org/articles/view/67963?key=946338907594d6d91dfd

TITLE: Specific peripheral B cell tolerance defects in patients with multiple sclerosis

AUTHOR CONTACT:
Eric Meffre
Yale University School of Medicine, New Haven, CT, USA
Phone: 1-203-737-4535; Fax: 1-203-785-7903; E-mail: eric.meffre@yale.edu

View this article at: http://www.jci.org/articles/view/68775?key=e407c6c0d214181b9fad


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. Nearly 50 percent increase in ICU admissions, new study says
2. The search for an early biomarker to fight atherosclerosis
3. Nearly Half of High Schoolers Text While Driving: Survey
4. iPads Could Affect Implanted Heart Devices, Early Study Finds
5. Wireless Pacemaker Shows Promise in Early Study
6. JCI early table of contents for May 8, 2013
7. Study finds nearly 5 million asthmatics worldwide could benefit from antifungal therapy
8. Children and Teens in Emergency Departments Who Are at Risk for Suicide: Nearly 20% Have Access to Guns
9. Living Long May Protect Against Early Alzheimers, Study Finds
10. Hospitals Enact Policies to Curb Early Childbirth
11. Nearly 20 percent of suicidal youths have guns in their home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2017)... ... April 25, 2017 , ... Somnoware, a leading provider of ... management module. Using this new feature, sleep physicians can now predict the likelihood ... positive airway pressure (CPAP), oral, or other forms of sleep apnea therapy. The ...
(Date:4/24/2017)... ... , ... Emmanuel College is introducing enhancements to its RN-to-BSN ... the fall of 2017, Emmanuel’s program will allow registered nurses (RN)s to earn a ... for as little as $14,528. These changes will enable nurses to complete their degree ...
(Date:4/24/2017)... Houston, TX (PRWEB) , ... April 24, 2017 , ... ... Holocaust Memorial Museum today to honor the victims of the Holocaust and Nazi persecution, ... remembrance ceremonies at Hadamar and Auschwitz on its CMATH Champions trip to Germany and ...
(Date:4/24/2017)... ... April 24, 2017 , ... Sean Fay is the ... Bag, Sonicare Toothbrush, Juiceman Juicer, and the George Foreman Grill (which sold more than ... marketer in the last 25 years. , Now, due to changes in the broadcast ...
(Date:4/24/2017)... ... April 24, 2017 , ... My T Chai, a South African company ... available for purchase on RevNutrition.com, a popular website specializing in sales of nutritional products. ... in ancient India and Siam. It spread across Asia and Africa quickly, and today ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... , April 18, 2017  Cardinal Health (NYSE: ... 1 fiscal 2017 earnings per share (EPS) guidance ... 2019.  This is in conjunction with this morning,s announcement ... Vein Thrombosis and Nutritional Insufficiency businesses. Cardinal ... continuing operations will be at the bottom of its ...
(Date:4/18/2017)... , April 18, 2017 Research and Markets ... 2017-2021" report to their offering. ... The global arthroscopy devices market to grow at a CAGR ... Global Arthroscopy Devices Market 2017-2021, has been prepared based on an ... the market landscape and its growth prospects over the coming years. ...
(Date:4/18/2017)... Calif. , April 18, 2017  Socionext ... of collaboration started in 2016, in which Socionext ... Brain SOINN". The companies achieved initial results in ... solution by Artificial Brain SOINN. The results will ... Big Sight, April 19-21, at booths 4505 & ...
Breaking Medicine Technology: