Navigation Links
JCI early table of contents for May 15, 2013
Date:5/15/2013

Hot on the TRAIL of graft vs. host disease

For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD). In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. Immune cells engineered to express higher levels of TRAIL killed the cells that cause GVHD and increased anti-tumor activity. In an accompanying commentary, Nelson Chao suggests that new therapeutics may take advantage of TRAIL-expressing cells to promote an anti-tumor response without putting patients at risk for GVHD.

TITLE: Fratricidal TRAIL+T cells suppress GVHD and augment anti-tumor activity after bone marrow transplantation

AUTHOR CONTACT:
Arnab Ghosh
Memorial Sloan-Kettering Cancer Center, New York, , USA
Phone: 646-888-2317; E-mail: ghosha1@mskcc.org

View this article at: http://www.jci.org/articles/view/66301?key=66e50de3cd0d7e99a4d8

ACCOMPANYING COMMENTARY

TITLE: Blazing a new TRAIL in hematopoietic cell transplantation

AUTHOR CONTACT:
Nelson J. Chao
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1011; Fax: 919-668-1091; E-mail: chao0002@mc.duke.edu

View this article at: http://www.jci.org/articles/view/69909?key=43f0101604c8f6bb12da

Researchers id
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Nearly 50 percent increase in ICU admissions, new study says
2. The search for an early biomarker to fight atherosclerosis
3. Nearly Half of High Schoolers Text While Driving: Survey
4. iPads Could Affect Implanted Heart Devices, Early Study Finds
5. Wireless Pacemaker Shows Promise in Early Study
6. JCI early table of contents for May 8, 2013
7. Study finds nearly 5 million asthmatics worldwide could benefit from antifungal therapy
8. Children and Teens in Emergency Departments Who Are at Risk for Suicide: Nearly 20% Have Access to Guns
9. Living Long May Protect Against Early Alzheimers, Study Finds
10. Hospitals Enact Policies to Curb Early Childbirth
11. Nearly 20 percent of suicidal youths have guns in their home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... 12, 2014 As DePuy Pinnacle hip ... U.S. courts, Bernstein Liebhard LLP notes the publication of ... to the failure of metal-on-metal hip replacements. The research, ... Journal of Bone & Joint Surgery, looked at 597 ... Replacement prostheses at least twelve months earlier. The blood ...
(Date:7/12/2014)... 12, 2014 Wright & Schulte LLC has ... , Inc., a subsidiary of Johnson & Johnson, on behalf ... pain after receiving a metal-on-metal DePuy Pinnacle hip replacement and ... the artificial hip implant. The DePuy hip lawsuit was filed ... of Texas (Case No. 3:14-cv-2427) where DePuy Pinnacle Hip ...
(Date:7/12/2014)... 12, 2014 As reported in this ... Standards and Technology), the June 25th, 2014 Supreme Court ruling ... world. It was also met with both cheers ... whether it was seen from an individual privacy perspective, or ... fact, there is now precedent which will require law enforcement ...
(Date:7/12/2014)... July 12, 2014 A recent article released ... a trio of suggestions for those seeking cosmetic surgical ... are rapidly approaching and the heat begins to enliven the ... their summer clothing, realizing that they didn’t work out as ... This can cause a sudden surge of people eager to ...
(Date:7/12/2014)... Seattle, Wa (PRWEB) July 12, 2014 ... by Doctors Sen and Samantha Pearson, a couple boasting ... chose to launch Restore My Vision Today as a ... that many ophthalmologists have become in their respective ... makes readers privy to a “secret” trove of pertinent ...
Breaking Medicine News(10 mins):Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 2Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 3Health News:DePuy Pinnacle Hip Lawsuit News: Bernstein Liebhard LLP Notes Release of New Study Tying Elevated Metal Ions to Metal-on-Metal Hip Failure 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 2Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 3Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 4Health News:Mobile Device Forensics Guidelines Play Key Role in Supreme Court’s Smartphone Evidence Warrant Decision 5Health News:Best Summer Cosmetic Surgeries Revealed in Article By Seattle Plastic Surgeon 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3
... MOUNTAIN VIEW, Calif. May 26, 2010 Complete ... announced that Genentech Inc., a wholly owned member of ... the company,s sequencing, bioinformatics and analytics services to sequence ... normal tissue. Tumor-normal pairs like this allow researchers to ...
... M.D., the HMS Henry Willard Williams Professor of Ophthalmology and ... Ear Infirmary and the Massachusetts General Hospital, has been awarded ... Advancement of Women Faculty. Dr. Miller is the sixteenth recipient ... HMS dean, in 1998. "I am delighted that HMS ...
... ... Dispensing System™ at ASCP as one option for addressing health reform’s new medication waste ... ... has surpassed 500 customers of its world-class software and proven hardware components to enhance ...
... to Congress comes ahead of expected changes to oversight ... -- A Congressional investigation of dietary herbal supplements has ... metals in nearly all products tested, plus myriad illegal ... York Times reported Wednesday. , The levels of ...
... scientists have been given the green light to test ... cure malignant melanoma, the most deadly type of skin ... Durrant of the University,s Division of Clinical Oncology within ... vaccine, which targets tumour cells without damaging healthy tissue, ...
... ... Site Puts Critical Information in Caregivers, Hands , ... (Vocus) May 26, 2010 -- Caregiver’s Touch ( www.caregiverstouch.com ... share a loved one’s information, today announced the launch of its online and smartphone ...
Cached Medicine News:Health News:Genentech uses Complete Genomics' human genome sequencing service to compare tumor and normal genome in patient with non-small cell lung cancer; results published in Nature 2Health News:Joan Miller, M.D., receives 2010 Leadership Award for the Advancement of Women Faculty 2Health News:Talyst Reaches Major Milestone: 500 Implementations in Long-Term Care, Acute Care and Corrections 2Health News:Talyst Reaches Major Milestone: 500 Implementations in Long-Term Care, Acute Care and Corrections 3Health News:Many Supplements Said to Contain Toxins, Make False Health Claims 2Health News:Vaccine hope for skin cancer sufferers 2Health News:Caregiver's Touch Empowers Families with an Organizational Wellness Solution 2
(Date:7/11/2014)... 2014  Australian drug delivery company, Phosphagenics Limited (ASX: ... A$19.3 million via a placement of A$16.3 million to ... U.S., Asia and ... purchase plan (SPP) to be offered to existing shareholders. ... two tranches. "This capital raising positions us ...
(Date:7/11/2014)... According to a new market ... (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - Global ... the global endoscopy devices market was valued at USD ... at a CAGR of 6.8% from 2013 to 2019, ... in 2019. Browse the full Endoscopy Devices Market ...
(Date:7/11/2014)... 11, 2014  Veran Medical Technologies, a ... the positive, cost-effective final results for the ... The SPiNPerc endobronchial percutaneous biopsy study results ... to biopsy when a traditional bronchoscopic method ... experience positive financial outcomes when more can ...
Breaking Medicine Technology:Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Veran Medical Publishes Lung Cancer Patient Management Study 2
Heavy duty, all purpose illuminator available in black only. Unique Clip Switch automatically turns off when returned to pocket. Pre-focused lens tip Heine XHL Halogen bulb for bright, concentrated l...
... Computer-compatible video magnifiers computer, integrates the latest ... be used with most computer monitors or ... that best suits an individuals unique viewing ... computer resolutions and frequencies, the Genie Pro ...
The Miniviewer magnifies text or color images 5 to 15 times. MiniViewers superior magnification, light weight and portable design offer you the ultimate in flexibility....
... The Discovery Inline Plus is an easy to ... so that the monitor (either a computer or a ... is not built in. It has a built in ... computer so that the magnified image from the video ...
Medicine Products: