Navigation Links
JCI early table of contents for May 15, 2013
Date:5/15/2013

Hot on the TRAIL of graft vs. host disease

For patients with leukemia and other hematological malignancies, transplantation of hematopoietic stem cells (HSCT) can be a powerfully effective therapy. In addition to the desirable anti-tumor effect, transplanted cells can also attack the host tissue, resulting in graft-versus-host disease (GVHD). In this issue of the Journal of Clinical Investigation, Arnab Ghosh and colleagues at Memorial Sloan-Kettering Cancer Center found that expression of a protein that causes cell death, TRAIL, in transplanted cells was critical for an effective anti-tumor response. Immune cells engineered to express higher levels of TRAIL killed the cells that cause GVHD and increased anti-tumor activity. In an accompanying commentary, Nelson Chao suggests that new therapeutics may take advantage of TRAIL-expressing cells to promote an anti-tumor response without putting patients at risk for GVHD.

TITLE: Fratricidal TRAIL+T cells suppress GVHD and augment anti-tumor activity after bone marrow transplantation

AUTHOR CONTACT:
Arnab Ghosh
Memorial Sloan-Kettering Cancer Center, New York, , USA
Phone: 646-888-2317; E-mail: ghosha1@mskcc.org

View this article at: http://www.jci.org/articles/view/66301?key=66e50de3cd0d7e99a4d8

ACCOMPANYING COMMENTARY

TITLE: Blazing a new TRAIL in hematopoietic cell transplantation

AUTHOR CONTACT:
Nelson J. Chao
Duke University Medical Center, Durham, NC, USA
Phone: 919-668-1011; Fax: 919-668-1091; E-mail: chao0002@mc.duke.edu

View this article at: http://www.jci.org/articles/view/69909?key=43f0101604c8f6bb12da

Researchers id
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Nearly 50 percent increase in ICU admissions, new study says
2. The search for an early biomarker to fight atherosclerosis
3. Nearly Half of High Schoolers Text While Driving: Survey
4. iPads Could Affect Implanted Heart Devices, Early Study Finds
5. Wireless Pacemaker Shows Promise in Early Study
6. JCI early table of contents for May 8, 2013
7. Study finds nearly 5 million asthmatics worldwide could benefit from antifungal therapy
8. Children and Teens in Emergency Departments Who Are at Risk for Suicide: Nearly 20% Have Access to Guns
9. Living Long May Protect Against Early Alzheimers, Study Finds
10. Hospitals Enact Policies to Curb Early Childbirth
11. Nearly 20 percent of suicidal youths have guns in their home
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/1/2015)... 01, 2015 Indiana Fiber Network, ... Provider, announces NewWays Networking, LLC (NewWays) selected IFN ... with IFN, NewWays is well positioned to scale ... for Internet bandwidth in rural parts of Indiana,” ... to Cory Childs IFN Enterprise Sales Manager, IFN ...
(Date:3/1/2015)... CrossFit Attollo is a CrossFit gym located ... special discount to new members. Now through the end ... month contract will receive their fourth month half off. ... $440. The three month contract is only $264, dropping ... fourth month comes in at only $55. The special saves ...
(Date:2/28/2015)... 28, 2015 In a recent episode ... of Game Change Athlete Development Services and ... the benefits of athlete development and player engagement during ... unique challenges that athletes face and how off-field activities ... , Fletcher became involved in athlete development issues while ...
(Date:2/28/2015)... February 28, 2015 The Classic ... offering a new special. Throughout all of March ... , This service can help overall ... and pain. Patients may notice certain symptoms that suggest ... These symptoms include: , 1.    Pain, clicking, and popping ...
(Date:2/28/2015)... Indosoft Inc , developers of ... are pleased to announce the development of Q-Suite 5.9. ... versions of Q-Suite, this new version will include enhancements ... new features to the leading edge call center software. ... will add features to enhance security and protection. Administrators ...
Breaking Medicine News(10 mins):Health News:NewWays Networking Selects Indiana Fiber Network, LLC as Fiber Transport Provider 2Health News:CrossFit Gym in Vancouver WA Offers Spring Special 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 2Health News:SCI TV Covers Athlete Development with Duncan Fletcher 3Health News:Classic Denture Center in Portland Oregon is Offering March Discount 2Health News:Indosoft Proudly Announces Q-Suite 5.9 Call Center Software for Asterisk 2
... , , ANAHEIM, Calif., ... the treatment capabilities of the Axxent(R) Electronic Brachytherapy, eBx(TM), System with ... the safety and feasibility for the treatment of non-melanoma skin cancers ... (AAPM) Meeting. The Company also announced that the first skin ...
... , , INDIANAPOLIS, July 27 ... advancing lung cancer treatment. On the heels of new FDA ... treatment for nonsquamous non-small cell lung cancer (NSCLC) in the maintenance ... cancer studies at the 13th World Conference on Lung Cancer (WCLC) ...
... , IRVINE, Calif., July 27 Accenx ... that its integration of BayCare Health System,s RxHistory ... questioning patient medication history and more time treating the patient. BayCare plans ... project,s end. , , In a business where ...
... , DOYLESTOWN, Pa., July 27 Prescient ... of the Year Award from Frost & Sullivan for Atherosclerosis Lesion ... related to heart attacks using the vProtect(TM) Luminal Shield. , ... occur when so-called "vulnerable" plaques rupture, releasing cholesterol and cellular debris ...
... , , INDIANAPOLIS, July 27 ... of 50 In d i a n a ... es to Watc h . ... Foundation, is sponsored by the Indiana Economic Development Corporation and its Small Business Development ...
... 27 SETO Holdings, Inc. (Pink Sheets: SETO) is pleased to ... hearing center in Virginia at 10120 West Broad Street, Suite G, ... hearing center in Montgomery Village (Gaithersburg), Maryland (18572 Office Park Drive). ... about September 1, 2009. , , ADVANCED is ...
Cached Medicine News:Health News:Xoft Expands Cancer Treatment Platform With Launch of Skin Cancer Electronic Brachytherapy Trial at AAPM Meeting 2Health News:Xoft Expands Cancer Treatment Platform With Launch of Skin Cancer Electronic Brachytherapy Trial at AAPM Meeting 3Health News:Xoft Expands Cancer Treatment Platform With Launch of Skin Cancer Electronic Brachytherapy Trial at AAPM Meeting 4Health News:Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting 2Health News:Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting 3Health News:Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting 4Health News:Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting 5Health News:Lilly to Unveil More Than 30 Studies at Premier Lung Cancer Meeting 6Health News:Accenx Information Exchange Platform Live With BayCare's RxHistory - Goal to Reach 8,200 Users 2Health News:Prescient Medical Receives Frost & Sullivan Product Innovation of the Year Award 2Health News:Prescient Medical Receives Frost & Sullivan Product Innovation of the Year Award 3Health News:SynCare, LLC Honored as Indiana Company to Watch 2Health News:SETO Holdings, Inc. Enters Into Two Additional Leases for Two New Hearing Centers in Maryland and Virginia 2
(Date:2/27/2015)... 27, 2015 Securities lawyers at Dunnam ... Pharmaceuticals, Ltd. (NASDAQ: SLXP ) in connection ... SLXP investors are encouraged to contact attorney Hamilton Lindley ... investigation focuses upon the shareholder value of the transaction. ... receive only $158.00 per share in cash. At least ...
(Date:2/27/2015)... , Feb. 27, 2015  Boston Scientific Corporation ... in the Barclays 2015 Annual Healthcare Conference on March ... Dan Brennan , executive vice president and ... president, Investor Relations, will participate in a 25-minute question ... analyst at approximately 1:05 p.m. ET. Following a 5-minute ...
(Date:2/27/2015)... ON , Feb. 27, 2015 /CNW/ - Covalon Technologies ... medical technologies company, today announced financial results for its ... For the three months ended December 31, 2014, revenue ... the quarter was $229,820 or $0.02 per share.  ... , said "I am very pleased with the significant ...
Breaking Medicine Technology:Boston Scientific to Participate in the Barclays 2015 Annual Healthcare Conference 2Covalon Announces First Quarter Financial Results 2Covalon Announces First Quarter Financial Results 3
Achieving Topical Hemostasis After Catheterization Does Not Have to Be Complicated or Costly. Clo-Sur P.A.D. is intended for topical use in the local management of bleeding wounds, such as vascular ...
Provides the security of suture and ease of automated knot tying for vascular closure of 5-8F....
... corrected with GP lenses. Even though good ... lenses will help the patient adapt to ... distortions of the corneal surface and provide ... challenge for even the most experienced practitioner. ...
... (MPM) devices allow physicians to successfully manage ... Aerotels MPM equipment, patients can sit in ... physicians conduct routine and comprehensive medical monitoring ... system, data is automatically recorded and transferred ...
Medicine Products: