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JCI early table of contents for May 1, 2013
Date:5/1/2013

HPV leaves its mark in oropharyngeal squamous cell carcinomas

Oropharyngeal squamous cell carcinoma (OPSCC) is a form of cancer that affects the cells lining the middle part of the throat, including the soft palate, the base of the tongue, the tonsils, and the pharynx. High-risk types of human papilloma virus (HPV) are increasingly detected in patients with OPSCC; however, HPV-positive OPSCC is highly curable and patients with HPV have better survival compared to HPV-negative patients, whose cancers are usually associate with alcohol and tobacco use. To understand the molecular mechanisms underlying these differences, Jochen Hess and colleagues at University Hospital Heidelberg in Heidelberg, Germany monitored changes in DNA modifications in HPV-positive and HPV-negative OPSCCs. In this issue of the Journal of Clinical Investigation, they identified a specific pattern of DNA modifications that is dependent on the presence of HPV. This DNA modification pattern was significantly correlated with improved survival in three separate groups of OPSCC patients. This study identifies a specific cellular alteration that can predict clinical outcomes for patients with OPSCC.

TITLE:
HPV-related methylation signature predicts survival in oropharyngeal squamous cell carcinomas

AUTHOR CONTACT:
Jochen Hess
University Hospital Heidelberg, Heidelberg, DEU
Phone: +49 (0)6221 56 39505; E-mail: jochen.hess@med.uni-heidelberg.de

View this article at: http://www.jci.org/articles/view/67010?key=e49a18f8713a54db36d3


Searching for therapeutic synergy in primary effusion lymphoma

Primary effusion lymphoma (PEL) is a rare, fatal form of aggressive B-cell lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV). The disease most commonly occurs
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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