Date:3/8/2013

al gut innervation is thought to contribute to debilitating motility disorders, such as irritable bowel syndrome. In order to prevent and treat these conditions, it is necessary to understand the molecular mechanisms that control the formation and function of the ENS. In this issue of the Journal of Clinial Investigation, Vassilis Pachnis and colleagues at the MRC National Institute for Medical Research in London found that the planar cell polarity (PCP) genes, Celsr3 and Fzd3 are required for the formation of the complex neural networks within the guts of mice. Inactivation of these genes resulted in disorganization of neuronal projections, slower gut transit time and abnormal colonic motility, indicating for the first time that improper ENS wiring contributes to gastrointestinal motility disorders. Future studies will be required to determine if mutations or dysfunction of these genes contributes to human gut motility disorders.

TITLE:
Planar cell polarity genes control the connectivity of enteric neurons

AUTHOR CONTACT:
Vassilis Pachnis
MRC National Institute for Medical Research, London, GBR
Phone: 00442088162113; E-mail: vpachni@nimr.mrc.ac.uk

View this article at: http://www.jci.org/articles/view/66759?key=75944e979331aac8ae06

ALSO IN THIS ISSUE

TITLE:
GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement

AUTHOR CONTACT:
Tsvee Lapidot
Weizmann Inst. of Science, Rehovot, ISR
Phone: 972-8-9342481; Fax: 972-8-9344141; E-mail: tsvee.lapidot@weizmann.ac.il

View this article at: http://www.jci.org/articles/view/64149?key=5dc391c0509e5cd16dbe

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Contact: Jillian Hurst press_releases@the-jci.org Journal of Clinical Investigation Source:Eurekalert

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