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JCI early table of contents for March 26, 2012
Date:3/20/2012

interactions between the various ciliopathy-associated proteins, but the precise mechanisms by which these interactions generate functional networks have remained elusive. In this issue of the JCI, Rachel and colleagues have now clearly linked two ciliopathy-associated proteins (CEP290 and MKKS). Surprisingly, the effects of a hypomorphic disease-causing Cep290 allele were rescued by loss of MKKS function, suggesting that it might be possible to treat some ciliopathies by fine tuning interactions within the expanding ciliary network.

COMMENTARY TITLE:

A so cilia network : cilia proteins start social networking

COMMENTARY AUTHOR CONTACT:

Frederic SAUDOU

Institut Curie, ORSAY, , FRA

Phone: +33169863024; E-mail: frederic.saudou@curie.fr

View this article at: http://www.jci.org/articles/view/62971?key=13cefd837237be0f9d06

RESEARCH ARTICLE TITLE

Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis

AUTHOR CONTACT:

Anand Swaroop

National Eye Institute, Bethesda, MD, USA

Phone: (301) 435-5754; E-mail: swaroopa@nei.nih.gov

View this article at: http://www.jci.org/articles/view/60981?key=b4a507d9065027e4f078


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Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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