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JCI early table of contents for March 26, 2012
Date:3/20/2012

specific hemoglobin scavenger protein, haptoglobin. These studies support an expanding body of research indicating that intravascular hemolysis is a pathological mechanism in several human diseases, including multi-organ dysfunction following either massive red blood cell transfusion or hemoglobin-based blood substitute therapy, the hemoglobinopathies, malaria, and other acquired and genetic hemolytic conditions.

COMMENTARY TITLE:

Hemolysis and cell-free hemoglobin drives an intrinsic mechanism for human disease

COMMENTARY AUTHOR CONTACT:

Mark Gladwin

University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Phone: 412-692-2117; E-mail: gladwinmt@upmc.edu

View this article at: http://www.jci.org/articles/view/62972?key=5505af9c496ee6d7eaae

RESEARCH ARTICLE TITLE:

Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy

CORRESPONDING AUTHOR CONTACT:

Paul Buehler

Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD, USA

Phone: 301-451-3953; E-mail: paul.buehler@fda.hhs.gov

View this article at: http://www.jci.org/articles/view/59770?key=19eae2af01a0c12f3198


CELL BIOLOGY
Uncovering cilia protein interactions

Cilia are unique cellular organelles found in nearly all cell types. In recent years, the importance of these organelles has been highlighted by the discovery that mutations in genes encoding proteins related to cilia biogenesis and function cause a class of complex syndromes termed ciliopathies. Emerging evidence suggests
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Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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