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JCI early table of contents for March 26, 2012
Date:3/20/2012

studies, this report highlights the promise of ATR and CHK1 inhibitors in targeted cancer treatment.

COMMENTARY TITLE:

CHK'ing p53-deficient breast cancers

COMMENTARY AUTHOR CONTACT:

Eric Brown

Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA

Phone: (215) 746-2805; Fax: (215) 573-2486; E-mail: brownej@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/63205?key=f40f5596cbb82d7ecffa

RESEARCH ARTICLE TITLE:

Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models

CORRESPONDING AUTHOR CONTACT:

Helen Piwnica-Worms

Washington University School of Medicine St. Louis, St Louis, MO, USA

Phone: 314 362-6812; E-mail: hpiwnica@wustl.edu

View this article at: http://www.jci.org/articles/view/58765?key=5f216a8dcd8a0d88872f


NEUROLOGICAL DISEASE
Parkinson Disease: Don't Mess with Calcium

The hallmark of the movement disorder Parkinson disease (PD) is progressive degeneration of dopaminergic neurons. Mitochondrial dysfunction, impaired ubiquitin-mediated proteolysis of α-synuclein, and endoplasmic reticulum (ER) stress are each implicated in the complex and poorly understood sequence of events leading to dopaminergic neuron demise. In this issue of the JCI, Selvaraj et al. report that in a mouse neurotoxin-based model of PD, reduced Ca2+ influx through transient receptor potential C1 (TRPC1) channels in the plasma membrane of dopaminergic neurons triggers a cell deathinducing ER stress response. These new findings suggest that TRPC1 channels
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Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

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