Navigation Links
JCI early table of contents for March 26, 2012
Date:3/20/2012

HOR CONTACT:

Fernanda De Felice

Federal University of Rio de Janeiro, Rio de Janeiro, , BRA

Phone: +552125626790 or +552125626515; E-mail: felice@bioqmed.ufrj.br

View this article at: http://www.jci.org/articles/view/57256?key=de0efc001f2106f5edc4

ACCOMPANYING ARTICLE

TITLE:

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

AUTHOR CONTACT:

Konrad Talbot

University of Pennsylvania, Philadelphia, PA, USA

Phone: (215) 589-2483; E-mail: talbotk2@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/59903?key=f9a078d273792af09d60


ONCOLOGY
Promise of new treatment options for chemotherapy-resistant breast cancers

p53 is lost or functionally impaired in many human cancers, and its absence is often associated with a poor response to conventional chemotherapy. Thus, much effort is currently devoted to developing novel treatments for p53-deficient malignancies. One approach is to target pathways that are selectively required for the survival of p53-deficient cancer cells, in effect exploiting a synthetic lethal interaction. Previous studies have demonstrated that inhibition of the ATR/CHK1 pathway in p53-deficient cells can induce such a synthetic lethal outcome. In this issue of the JCI, Ma et al. take these findings a step closer to the clinic by demonstrating that highly specific inhibitors of CHK1 synergize with chemotherapy to stem progression of p53-deficient triple-negative breast cancers in a xenotransplant model of this disease. Together with other recent
'/>"/>

Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6

Related medicine news :

1. JCI early table of contents for March 19, 2012
2. Dr. Betty Vohr honored for Early Hearing Detection and Intervention Excellence
3. Nearly 800,000 deaths prevented due to declines in smoking
4. Study: US tobacco-control efforts prevented nearly 800,000 cancer deaths between 1975 and 2000
5. Mild Winter Heralds Early Sneezin Season
6. New blood test for early cancer detection developed by Ben-Gurion University researchers
7. Fever control using external cooling reduces early mortality in septic shock patients
8. Researchers see differences in Autism brain development as early as 6 months
9. To avoid early labor and delivery, weight and diet changes not the answer
10. Positive parenting during early childhood may prevent obesity
11. Anesthesia in Early Childhood May Be Linked to ADHD
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David Leadbetter ... to bestow a Juvent Sports Achievement award upon an ... The award commemorated and congratulated McKitrick for her record ... her first amateur tournament in 1979 and most recently ...
(Date:1/22/2015)... 22, 2015 Thousand of GranuFlo lawsuits ... recalled its GranuFlo and NaturaLyte dialysis concentrates continue to ... U.S. District Court, District of Massachusetts, Bernstein Liebhard LLP ... Court has remanded a case filed by the state ...
(Date:1/22/2015)... 20 years, Dr. David Cruz of Cruz Chiropractic Care ... about every type of injury that can result from car accidents ... years, the team at Doctors on Liens has been ... With the combined breadth of experience between the two, ...
(Date:1/22/2015)... 2015 Joan Lunden, award-winning American journalist, ... the upcoming 32nd Annual Miami Breast Cancer Conference ... Resource®, LLC (PER®) , shares that “a fast-growing, virulent” ... if she had not followed up her clean mammogram ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6
... Raise Funds for Research, PHILADELPHIA, Oct. 8 ... chronic (incurable) disease that can,result in severe joint pain ... sun sensitivity, and other health effects,including organ failure and ... 15 and 44 -- although men and women of ...
... Month, SAN DIEGO, Oct. 8 The ... with Sparhawk Corporation to raise,funds through a Sparhawk ... new alliance, supporters of SKCC can help raise ... at, http://skcc.org/shop . The eMall has links to ...
... that will ... LANSING, Mich., Oct. 8 In a bold move ... up to 500 new jobs for,Lansing and further revitalize the ... Insurance Company of America announced,today it will establish its new ...
... 2007 /PRNewswire-FirstCall/,-- Although rising health care costs ... most jurisdictions do not offer preventive and ... issues, according to,a survey of local governments ... leadership and management organization, and sponsored by ...
... Your Escape Plan, October 7-13, Is Backdrop ... World Institute on Disability Better ... The World Institute on Disability,and the American Red ... awareness and action program to help volunteers better,serve people ...
... Edward G.,Rendell today accepted the Health Care Reform Pioneer ... work to reform,Pennsylvania,s health care system through his groundbreaking ... progress in our efforts to improve access to health,care ... said. "That is why,I will be touring the state ...
Cached Medicine News:Health News:October is Lupus Awareness Month 2Health News:October is Lupus Awareness Month 3Health News:Sidney Kimmel Cancer Center to Boost Revenue Through Support From E-Fundraising Mall 2Health News:Accident Fund Will Make Board of Water & Light's Ottawa Street Station Power Plant in Lansing Its New National Headquarters 2Health News:Accident Fund Will Make Board of Water & Light's Ottawa Street Station Power Plant in Lansing Its New National Headquarters 3Health News:ICMA/CIGNA Survey: U.S. Cities and Counties Begin to Focus on Health Risks and Costs 2Health News:ICMA/CIGNA Survey: U.S. Cities and Counties Begin to Focus on Health Risks and Costs 3Health News:ICMA/CIGNA Survey: U.S. Cities and Counties Begin to Focus on Health Risks and Costs 4Health News:World Institute on Disability and American Red Cross to Announce Plan to Train Red Cross Volunteers to Better Assist People With Disabilities During Disasters 2Health News:Governor Rendell Accepts National Health Care Reform Pioneer Award 2
(Date:1/23/2015)... 23, 2015 More than a third of reproductive-aged women ... with private insurance, filled a prescription for an opioid pain ... this week,s Morbidity and Mortality Weekly Report (MMWR). ... treat moderate to severe pain.  They are also found in ...
(Date:1/23/2015)... Jan. 23, 2015  HyGreen, Inc., a leader in hand ... with RCA Medical, a subsidiary of Ascendis Health Limited, ... Each year, hundreds of millions of patients around ... organisms are transmitted from patient to patient via the ...
(Date:1/23/2015)... Jan. 23, 2015 Cord Blood America, Inc. ( www.cordblood-america.com ... the "Company")  filed a Preliminary Proxy Statement, Schedule 14A, with ... and provides an update for shareholders detailing why a "YES" ... Dear Shareholders, As we reflect upon ...
Breaking Medicine Technology:Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3HyGreen Partners with RCA Medical in Johannesburg, South Africa 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4
... The Shandon Cryotome FE and FSE are ... Thermo Electron. The microtome is outside of ... cleaning, as well as faster temperature adjustment. ... operation. Complete temperature controls on the main ...
A standard, durable and reliable indirect....
Designed to retain the desired curve during oral intubation....
Facilitates intubation of tracheal tubes....
Medicine Products: