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JCI early table of contents for March 26, 2012
Date:3/20/2012

HOR CONTACT:

Fernanda De Felice

Federal University of Rio de Janeiro, Rio de Janeiro, , BRA

Phone: +552125626790 or +552125626515; E-mail: felice@bioqmed.ufrj.br

View this article at: http://www.jci.org/articles/view/57256?key=de0efc001f2106f5edc4

ACCOMPANYING ARTICLE

TITLE:

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

AUTHOR CONTACT:

Konrad Talbot

University of Pennsylvania, Philadelphia, PA, USA

Phone: (215) 589-2483; E-mail: talbotk2@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/59903?key=f9a078d273792af09d60

ONCOLOGY
Promise of new treatment options for chemotherapy-resistant breast cancers

p53 is lost or functionally impaired in many human cancers, and its absence is often associated with a poor response to conventional chemotherapy. Thus, much effort is currently devoted to developing novel treatments for p53-deficient malignancies. One approach is to target pathways that are selectively required for the survival of p53-deficient cancer cells, in effect exploiting a synthetic lethal interaction. Previous studies have demonstrated that inhibition of the ATR/CHK1 pathway in p53-deficient cells can induce such a synthetic lethal outcome. In this issue of the JCI, Ma et al. take these findings a step closer to the clinic by demonstrating that highly specific inhibitors of CHK1 synergize with chemotherapy to stem progression of p53-deficient triple-negative breast cancers in a xenotransplant model of this disease. Together with other recent
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Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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