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JCI early table of contents for Mar. 1, 2013
Date:3/1/2013

e Journal of Clinical Investigation, Tarek Fahmy and colleagues at Yale University report the development of a nanogel-based delivery system that targets an immunosuppressive drug (mycophenolic acid) directly to tissues associated with immune cells. A nanogel is composed of a polymer containing pores that can be loaded with drug compounds. Fahmy and colleagues tested the mycophenolic acid-loaded nanogel in a mouse model of lupus. Mice treated with the nanogel lived longer than untreated mice or mice treated with mycophenolic acid alone. Additionally, the onset of kidney damage, a common complication of lupus, was delayed in nanogel-treated mice. These studies suggest that nanogel-based therapies may be useful in the treatment of SLE.

TITLE:
Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus

AUTHOR CONTACT:
Tarek Fahmy
Yale University, New Haven, CT, USA
Phone: 203-512-1699; Fax: 203-432-1043; E-mail: tarek.fahmy@yale.edu

View this article at: http://www.jci.org/articles/view/65907?key=2a162626b2b9eb600213


ALSO IN THIS ISSUE

TITLE:
STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients

AUTHOR CONTACT:
Young Kim
Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD, USA
Phone: 410-550-0460; E-mail: ykim76@jhmi.edu

View this article at: http://www.jci.org/articles/view/60083?key=88009f6e6231c06368aa

TITLE:
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer

AUTHOR CONTACT:
Roland Ullrich
Max Planck Institute for Neurological Research, Cologne
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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