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JCI early table of contents for June 24, 2013
Date:6/24/2013

ssue of the Journal of Clinical Investigation, Sylvia Knapp and colleagues at the Medical University of Vienna investigated how OxPL block macrophage activity. Using a mouse model of bacterial peritonitis, Knapp and colleagues found that the protein WAVE1 mediates the effects of OxPL in macrophages. Mice lacking WAVE1 survived longer than normal mice after bacterial infection. Additionally, peritoneal fluid from human patients with end-stage renal failure contained OxPL and inhibited phagocytosis via WAVE1. These data identify WAVE1 as an important mediator of bacterial pathogenicity and suggest that it could serve as a therapeutic target in severe bacterial infections.

TITLE:WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs

AUTHOR CONTACT: Sylvia Knapp
Medical University Vienna, Vienna, AUT
Phone: +43-1-40400-5139; Fax: +43-1-40400-5167; E-mail: sylvia.knapp@meduniwien.ac.at

View this article at: http://www.jci.org/articles/view/60681?key=ddf9c6d38d19cf06d764


Modified immune cells reduce flu severity in mice

Influenza A viruses cause significant morbidity and mortality worldwide. Current treatment strategies are limited to antiviral medications; however, many forms of the virus have become resistant to these medications. In this issue of the Journal of Clinical Investigation, Kanta Subbarao and colleagues at the National Institute of Allergy and Infectious Disease describe a method to modify immune cells, known as dendritic cells, to enhance the immune response to influenza in mice. The modified dendritic cells decreased the severity of the disease in influenza A-infected mice, indicated that such a strategy could potentially be used to treat viral infections.

TITLE: Antigen-activated dendritic cells ameliorate
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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