Navigation Links
JCI early table of contents for June 24, 2013
Date:6/24/2013

ith all three types of dendritic cells elicited an immune response, which peaked after 3-4 vaccinations with dendritic cells. Patients that received the specially modified dendritic cells had a longer lasting immune response and fewer circulating melanoma cells. Of the two patients that had active disease, treatment with modified dendritic cells resulted in a partial clinical response in one and a complete clinical response in the other. These results suggest that modification of dendritic cells so that they recognize cP-produced tumor antigens enhances immune recognition of melanoma cells.

This study was funded by Duke Clinical Research Institute/Duke Translational Medicine Institute, Duke Melanoma Consortium, and Duke University Department of Surgery. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

TITLE: Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

AUTHOR CONTACT: Scott Pruitt
Merck Research Laboratories, Rahway, NJ, USA
Phone: 919-632-6118; Fax: 732-594-5512; E-mail: scott.pruitt@merck.com

View this article at: http://www.jci.org/articles/view/67544?key=ca11555dad2fe390851f


Researchers identify a protein that hinders the immune response to severe bacterial infections

Clearance of invading pathogens is essential to prevent overwhelming inflammation and sepsis that are symptomatic of bacterial peritonitis, an infection of the abdominal cavity. Macrophages are immune cells that participate in the immune response by engulfing and digesting pathogens, a process called phagocytosis. Oxidized phospholipids (OxPL) are molecules generated in response to infection that can prevent bacterial clearance by phagocytosis. In this i
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. An Early Start for Your Child with Autism
3. Early Study Finds Some Promise for Lung Cancer Vaccine
4. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
5. JCI early table of contents for April 9, 2012
6. Eye Tremors May Aid Early Diagnosis of Parkinsons: Study
7. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
8. First contact: Early intervention key in diagnosis and treatment of serious mental illness
9. Brain Tumor Vaccine Shows Promise in Early Trial
10. Role of Screening, Monitoring in Early Kidney Disease Unclear
11. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/3/2015)... ... August 03, 2015 , ... ... to decline by 39 percent, according to market research compiled for the National ... from the U.S. Department of Labor, Bureau of Labor Statistics. As the number ...
(Date:8/3/2015)... (PRWEB) , ... August 03, 2015 , ... Dignity Health ... Health Arizona General Hospital Emergency Room – Gilbert, opening in August. The new ... this year in the West Valley. , “Dr. Baldwin is an excellent leader ...
(Date:8/3/2015)... ... 2015 , ... Constantin Vasilica, 48 from Romania wanted to have an alternative ... many years of suffering and using medications with strong side effects. This had already ... extra time off or wait longer hours in the waiting rooms. Instead, he went ...
(Date:8/3/2015)... ... August 03, 2015 , ... Foot and Ankle ... new associate podiatrist, creating the largest medical practice in the Mid-Atlantic region – and ... FASMA operates 21 locations with 33 doctors. , Dr. Hetal Kathrotiya-Mago is a Maryland ...
(Date:8/3/2015)... ... August 03, 2015 , ... ... Council (ICC) announce an agreement to collaborate across a wide range of ... increasing building code knowledge among architects. , “Our combined membership, consisting of practicing ...
Breaking Medicine News(10 mins):Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 2Health News:Dental Association Announces Impending Reduction of Dental Laboratories Could Impact Dentists 3Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 2Health News:Dignity Health Names Dr. Norris A. Baldwin, Jr. Facility Medical Director of New Freestanding Emergency Room 3Health News:Chinese Health Care Provider Heshoutang Now Give Patients Complimentary Online Healing Options 2Health News:Chinese Health Care Provider Heshoutang Now Give Patients Complimentary Online Healing Options 3Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 2Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 3Health News:Leading Foot and Ankle Medical Practice Adds Three New Podiatrists 4Health News:Architects, International Code Council Ink Five-Year Collaborative Agreement 2Health News:Architects, International Code Council Ink Five-Year Collaborative Agreement 3
... Nov. 6 Those biopharmaceutical companies that are ... their business models will be best positioned to ... according to a white paper published today by ... equity firm, and Health Advances, a leading healthcare ...
... 6 Bulletproof Blog , the ... with former Speaker of the U.S. House of Representatives ... to effect America,s business landscape. , In the interview, ... impacting the crossroads of business and government, including healthcare ...
... Nov. 6 Allied World Assurance,Company Holdings, Ltd ... World U.S.,Nicole Baummer, Assistant Vice President for Private/Not-for-Profit ... Lines,Claims, will be speaking at this year,s Professional ... in Chicago, Illinois,November 11-13, 2009. , ...
... 6 We Work for Health, an alliance of ... released the results of a first-of-its-kind economic impact study ... passed many of the traditional resource-based industries on which ... same range of importance as some of the new, ...
... Nov. 6 The current health care debate in the ... choices and life expectancy have been suggested but seldom clearly ... year on health care for every 80 year old, while ... octogenarians have a 20 percent less chance of dying than ...
... food choices in study , FRIDAY, Nov. 6 (HealthDay News) ... choices, researchers say. , The new study included 542 male ... irregular shifts. The average age of the participants was 49, ... sleep medicine division at Harvard Medical School found that adequate ...
Cached Medicine News:Health News:Surviving Healthcare Reform: How Biopharma Companies Can Come Out on Top 2Health News:Former House Speaker Newt Gingrich Shares Insights on Healthcare Reform and the Federal Pay Czar with BulletproofBlog.com 2Health News:Allied World's Nicole Baummer and Marjorie Thompson to Speak at PLUS International Conference 2Health News:Allied World's Nicole Baummer and Marjorie Thompson to Speak at PLUS International Conference 3Health News:New Study: Life Science Jobs Total 77,000 in Washington State 2Health News:New Study: Life Science Jobs Total 77,000 in Washington State 3Health News:Carnegie Mellon Researcher Links Health Care Debate to Risk of Dying in the U.S. and Europe 2Health News:Carnegie Mellon Researcher Links Health Care Debate to Risk of Dying in the U.S. and Europe 3Health News:Carnegie Mellon Researcher Links Health Care Debate to Risk of Dying in the U.S. and Europe 4
(Date:7/31/2015)... Magnaquest, a leading Subscription ... cloud computing operators has signed a Proof of ... Internet of Things (IoT) related initiative. The PoC ... model.      (Logo: http://photos.prnewswire.com/prnh/20140807/700645 ) ... business innovations to make healthcare services more accessible ...
(Date:7/30/2015)... 2015 Mettler-Toledo International Inc. (NYSE: MTD ... below are the highlights: , Sales in ... the prior year. Reported sales decreased 4% as currency ... , Net earnings per diluted share as reported (EPS) ... Adjusted EPS was $2.80 , an increase of ...
(Date:7/30/2015)... Calif. , July 30, 2015 IRIDEX ... will release its second quarter 2015 financial results after ...   In conjunction with the release, the Company will ... 5:00 p.m. Eastern Time on Thursday, ... the quarter and other business developments. Interested ...
Breaking Medicine Technology:Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 2Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 3Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 4Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 5Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 6Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 7Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 8Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 9Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 10Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 11Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 12Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 13Mettler-Toledo International Inc. Reports Second Quarter 2015 Results 14IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: