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JCI early table of contents for June 24, 2013
Date:6/24/2013

ith all three types of dendritic cells elicited an immune response, which peaked after 3-4 vaccinations with dendritic cells. Patients that received the specially modified dendritic cells had a longer lasting immune response and fewer circulating melanoma cells. Of the two patients that had active disease, treatment with modified dendritic cells resulted in a partial clinical response in one and a complete clinical response in the other. These results suggest that modification of dendritic cells so that they recognize cP-produced tumor antigens enhances immune recognition of melanoma cells.

This study was funded by Duke Clinical Research Institute/Duke Translational Medicine Institute, Duke Melanoma Consortium, and Duke University Department of Surgery. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, etc.

TITLE: Melanoma immunotherapy using mature DCs expressing the constitutive proteasome

AUTHOR CONTACT: Scott Pruitt
Merck Research Laboratories, Rahway, NJ, USA
Phone: 919-632-6118; Fax: 732-594-5512; E-mail: scott.pruitt@merck.com

View this article at: http://www.jci.org/articles/view/67544?key=ca11555dad2fe390851f


Researchers identify a protein that hinders the immune response to severe bacterial infections

Clearance of invading pathogens is essential to prevent overwhelming inflammation and sepsis that are symptomatic of bacterial peritonitis, an infection of the abdominal cavity. Macrophages are immune cells that participate in the immune response by engulfing and digesting pathogens, a process called phagocytosis. Oxidized phospholipids (OxPL) are molecules generated in response to infection that can prevent bacterial clearance by phagocytosis. In this i
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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