Navigation Links
JCI early table of contents for June 24, 2013
Date:6/24/2013

lance

AUTHOR CONTACT: Janos Peti-Peterdi
University of Southern California, Los Angeles, CA, USA
Phone: 323-442-4337; E-mail: petipete@usc.edu

View this article at: http://www.jci.org/articles/view/68095?key=c031dab289e762e8a011


Targeting melanoma with modified dendritic cells

In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic cells, a component of the immune system, were tested in patients with melanoma. All cells express a complex known as the proteasome, which acts as the garbage disposal for the cell. There are two types of proteasomes: constitutive proteasomes (cPs), which are found in normal tissues, and immunoproteasomes (iPs), which are found in stressed or damaged cells. In a damaged cell, the iP generates protein fragments that are displayed on the surface of the distressed cells, triggering recognition by dendritic cells and subsequent destruction by the immune system. Most cancers, including melanoma, exclusively express cPs, making it impossible for them to express the protein fragments that are recognized by the immune system. To make it easier for the immune system to find cancer cells, Pruitt and colleagues engineered a specific type of immune cell, known as a dendritic cell, that recognizes protein fragments of cancer specific antigens made by cPs. The engineered dendritic cells were then injected into patients that were in remission from melanoma. The trial consisted of 4 patients that were vaccinated with regular dendritic cells, 3 patients that received cells that underwent a control treatment, and 5 patients that received dendritic cells that recognized cancer-made protein fragments. Vaccination w
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. An Early Start for Your Child with Autism
3. Early Study Finds Some Promise for Lung Cancer Vaccine
4. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
5. JCI early table of contents for April 9, 2012
6. Eye Tremors May Aid Early Diagnosis of Parkinsons: Study
7. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
8. First contact: Early intervention key in diagnosis and treatment of serious mental illness
9. Brain Tumor Vaccine Shows Promise in Early Trial
10. Role of Screening, Monitoring in Early Kidney Disease Unclear
11. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 30, 2014 Healthpointe is proud to ... advanced foot and ankle reconstruction surgeries to assist patients ... Dr. Cortés specializes in the diagnosis and treatment of ... She is also trained to perform advanced Foot and ... Dr. Cortés is also fluent in Spanish. , Reconstructive ...
(Date:9/30/2014)... Milpitas, California (PRWEB) September 30, 2014 ... for its first “crowdfunding” campaign through GoFundMe. The campaign, ... live, was for a portion of the funds necessary ... all-electric bus for the Stockton Unified School District (SUSD). ... and will provide a portion of the funds necessary ...
(Date:9/30/2014)... per cent of Canadians report being stressed or very stressed ... poor mental and physical health, not everyone is affected the ... those most likely to sweat the small stuff chronic ... Concordia University has found a way to identify those most ... working to stop stress before it gets out of control. ...
(Date:9/30/2014)... of Dental Medicine have been awarded a $11.8 million, ... Craniofacial Research, part of the National Institutes of Health, ... cleft lip and cleft palate and to expand the ... and Pennsylvania. , Orofacial clefts (OFCs), which are ... form when a baby,s mouth doesn,t develop properly during ...
(Date:9/30/2014)... Four scientists at Cold Spring Harbor Laboratory (CSHL) ... two new CSHL grants announced in Washington today. The ... the National Institutes of Health (NIH), totaling $46 million ... funding for the BRAIN Initiative. , ... launched by the President in the spring of 2013. ...
Breaking Medicine News(10 mins):Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 2Health News:Fellowship-Trained and Board-Certified Orthopedic Specialist Now Performing Advanced Foot & Ankle Reconstruction Surgeries 3Health News:ADOMANI Raises More Than 100,000 Dollars Through GoFundMe to Convert a School Bus 2Health News:ADOMANI Raises More Than 100,000 Dollars Through GoFundMe to Convert a School Bus 3Health News:How to predict who will suffer the most from stress 2Health News:Pitt team searches for genetic roots of cleft lip, palate 2Health News:4 Cold Spring Harbor Laboratory scientists will contribute to President Obama's BRAIN Initiative under new NIH grants 2Health News:4 Cold Spring Harbor Laboratory scientists will contribute to President Obama's BRAIN Initiative under new NIH grants 3
... man, who tested negative for the human form of the ... Diseases, in Bucharest// , after he exhibited flu like symptoms. ... H5N1 had infected the birds in the area. ... Bucharest national laboratory. The Ministry of Health has designated the ...
... rising obesity rates by 2010 will fall flat on its face, ... to a recent study// . Though local level work is going ... about the thrust given to this area. The public Health Minister, ... lots left to be done. Obesity has sent the NHS expenditure ...
... and Research Institutes, Inc (NDRI) in New York ... explored the role// of social supports, spirituality, religiousness, ... of recovery from addiction. The study reveals markedly ... as a decrease in stress when people were ...
... A 91-year-old woman in British Columbia died a lonely death after ... sons, is hopeful that his mom’s death// will bring about some ... ,The hospital separated Fanny Albo from her ailing husband who ... in Trail. Fanny Albo and her husband had been together for ...
... to a new Japanese study appearing in the current ... green tea daily may help reduce risk of dementia,.// ... related with the risk of having cognitive impairment in ... , Dr. Shinichi Kuriyama of Tohoku University Graduate ...
... Germany has reported that regular peelings and scrubbing with a ... the skin is stretched during pregnancy. // ,Peelings and ... magazine said. The same is true of massages. ... use of certain substances can help. ...
Cached Medicine News:Health News:Drug Addiction Recovery Buffered by Spirituality 2
(Date:9/30/2014)... 30, 2014 BioStructures, LLC has been ... of Tissue Banks (AATB), it was announced today ... Accreditation follows an intensive nine-month process, ... AATB inspector.  It establishes that the level of ... meets or exceeds the standards set by the ...
(Date:9/30/2014)... , Sept. 30, 2014  Georgia-Pacific Professional ... towels and tissue for a wide range of ... of its product lines in healthcare, including hospitals, ... Georgia-Pacific Professional is introducing its healthcare products and ... Professional understands the importance of infection control in ...
(Date:9/30/2014)... 30, 2014 Passport Health, one of the ... has launched FluFree.com, a website designed to promote, educate ... For 20 years, Passport Health has provided its clients ... launch of FluFree.com is designed to address the growing ... of people who actually chose to get vaccinated. ...
Breaking Medicine Technology:Biostructures, LLC Earns AATB Accreditation 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 2Georgia-Pacific Professional Brings Its Success in Medical Solutions to the Dental Community 3Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 2Passport Health Launches FluFree.com - Aims To Improve Flu Vaccination Rates and Fulfill Growing Public Health Priority 3
... provides a solution for instantaneously locating ... or unauthorized movement of patients or ... key concern. Certain patients, such as ... patients with highly communicable diseases, patients ...
... AeroScout Wi-Fi Tags are small, long-life ... communications standard. By attaching tags to mobile ... network infrastructure to locate and track many ... efficiency, productivity and revenues. The AeroScout T2 ...
... can be programmed to send ... a device needs servicing, preventive ... a patient or staff member ... an ID-tag includes the current ...
... patent pending solution using Radio Frequency ... smart label to promote patient safety ... wrong-procedure surgery. This simple to use ... surgeon with the operating room staff ...
Medicine Products: