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JCI early table of contents for June 24, 2013
Date:6/24/2013

TITLE: Linking MLL and the HGF-MET signaling pathway in liver cancer

AUTHOR CONTACT: Snorri Thorgeirsson
Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA
Phone: 301-496-1935; Fax: 301-496-0734; E-mail: snorri_thorgeirsson@nih.gov

View this article at: http://www.jci.org/articles/view/70235?key=2a211148658707001dbb


Kidneys strike a balance in body pH

The body's acid-base balance is modulated in part by the action of the kidney, where cells alter bodily pH by excreting acid or base into the urine in response to high levels of acid (acidosis) or base (alkaloidosis). It is unclear how these cells communicate with the rest of the kidney and participate in integrated physiological processes. In this issue of the Journal of Clinical Investigation, Dmitri Firsov and colleagues at the University of Lausanne found that a receptor known as OXGR1 in the kidney responds to levels of a metabolite, αKG, to coordinate the kidney's response to acidosis and alkaloidosis. In the accompanying commentary, Jnos Peti-Peterdi of UCLA points out that further research will be necessary to fully understand the systemic role of αKG .

TITLE: alpha-ketoglutarate regulates acid-base balance through an intra-renal paracrine mechanism

AUTHOR CONTACT: Dmitri Firsov
Department of Pharmacology and Toxicology, Lausanne, CHE
Phone: ++41216925406; E-mail: dmitri.firsov@unil.ch

View this article at: http://www.jci.org/articles/view/67562?key=408922b97f085ce40b13

ACCOMPANYING COMMENTARY

TITLE: Mitochondrial TCA-cycle intermediates regulate body fluid and acid-base ba
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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