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JCI early table of contents for June 24, 2013
Date:6/24/2013

ARY

TITLE: Chronic THC intake modifies fundamental cerebellar functions

AUTHOR CONTACT: Nephi Stella
CHDD, Seattle, , USA
Phone: 206-221-5220; E-mail: nstella@u.washington.edu

View this article at: http://www.jci.org/articles/view/70226?key=1251fa84d26041e7a671


Signal crossing in liver cancer

Many cancers rely on specific molecules, known as oncogenes, to mediate their initiation and growth; however, researcher have not identified oncogenes that drive hepatocellular carcinoma (HCC). This lack of specific targets makes it difficult to select therapies for HCC patients. In this issue of the Journal of Clinical Investigation, James Hsieh and colleagues at Memorial Sloan-Kettering Cancer Center found that the protein MLL, which is associated with mixed lineage leukemia and developmental disorders, is linked to the HGF-MET cell signaling pathway, which mediates metastasis in HCC. Using transgenic mice and HCC cell lines, Hsieh and colleagues demonstrated that HGF-MET signaling stabilizes MLL so that it can trigger the expression of genes required for HCC metastasis. In a companion commentary, Snorri Thorgeirsson at the National Cancer Institute discusses how future research can build on these findings and aid in the development of therapeutic strategies for HCC.

TITLE: HGF-MET signals via the MLL-ETS2 in hepatocellular carcinoma

AUTHOR CONTACT: James Hsieh
Memorial Sloan-Kettering Cancer Center, New York, NY, USA
Phone: 6468883263; E-mail: hsiehj@mskcc.org

View this article at: http://www.jci.org/articles/view/65566?key=554e80f5f250a1961c9b

ACCOMPANYING COMMENTARY


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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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