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JCI early table of contents for June 24, 2013
Date:6/24/2013

RESEARCH BRANCH, NICHD, NIH, DHHS, Detroit, MI, USA
Phone: 313-993-2700; Fax: 313-993-2694; E-mail: romeror@mail.nih.gov

View this article at: http://www.jci.org/articles/view/70431?key=a945472a049b383326f4


The inflammatory consequences of chronic cannabis use

Chronic cannabis use has been associated with defects in the regions of the brain that regulate motor control, but how the active component of the drug, THC, mediates these defects is incompletely understood. In this issue of the Journal of Clinical Investigation, Andres Ozaita and colleagues at Universitat Pompeu Fabra in Barcelona exposed mice to sub-chronic doses of THC and observed deficiencies in learning and coordination associated with brain inflammation and downregulation of the THC receptor CB1R. Furthermore, Ozaita and colleagues found that the defects in these animals could be prevented by treatment with an anti-inflammatory agent. This work suggests that brain inflammation resulting from decreased CB1R is directly related to the learning and motor coordination side effects associated with cannabis consumption. In the accompanying commentary, Nephi Stella at the Center for Human Development and Disability in Seattle points out that these findings raise questions about the safety of medicinal THC applications.

TITLE: Mechanisms underlying the cerebellar deficits produced by repeated cannabis exposure

AUTHOR CONTACT: Andres Ozaita
Universitat Pompeu Fabra, Barcelona, ESP
Phone: +34 933160823; E-mail: andres.ozaita@upf.edu

View this article at: http://www.jci.org/articles/view/67569?key=f8f84f1e2997cbac8aad

ACCOMPANYING COMMENT
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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