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JCI early table of contents for June 24, 2013
Date:6/24/2013

ticles/view/69399?key=bb81f4707f101fecbcaa">http://www.jci.org/articles/view/69399?key=bb81f4707f101fecbcaa


Gene dysregulation underlies preeclampsia

Preeclampsia is a medical condition affecting 4-8% of pregnancies that is characterized by high maternal blood pressure, excess protein in maternal urine, and reduced fetal growth. If left untreated, it can develop into eclampsia, which causes life threatening seizures. Apart from delivery, there is no known cure. In this issue of the Journal of Clinical Investigation, researchers led by Susan Fisher at the University of California, San Francisco, examined cytotrophoblast cells, which help to form the placenta, from women that developed preeclampsia and healthy controls. They found that the cytotrophoblasts from patients with preeclampsia exhibited changes in gene expression, particularly in the gene SEMA3B. Increased expression of SEMA3B in normal cytotrophoblasts recreated some of the features of the cytotrophoblasts from patients with preeclampsia. In the accompanying Attending Physician article, Roberto Romero of the National Institute of Child Health and Development discusses how these findings are our first insight into the pathogenesis of preeclampsia.

TITLE: Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia

AUTHOR CONTACT: Michael McMaster
University of California San Francisco, San Francisco, CA, USA
Phone: 415-514-0172; E-mail: mcmaster@cgl.ucsf.edu

View this article at: http://www.jci.org/articles/view/66966?key=21b97f984b68c6c0c8d7

ACCOMPANYING ATTENDING PHYSICIAN

TITLE: Preeclampsia: a link between trophoblast dysregulation and an anti-angiogenic state

AUTHOR CONTACT: ROBERTO ROMERO
PERINATOLOGY
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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