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JCI early table of contents for June 18, 2012
Date:6/18/2012

AGING
Preventing cellular aging and aging-related degenerative diseases

Age-associated degeneration is caused, at least in part, by accumulated cellular damage, including DNA damage, but how these types of damage drive aging remains unclear. Dr. Paul Robbins and colleagues at the University of Pittsburgh sought to address this question using a mouse model of DNA repair deficiency. The Robbins team found that DNA damage drives aging, in part, by activating NF-κB, a transcription factor that responds to cellular damage and stress. They report that inhibition of NF-κB reduces oxidative stress, oxidative DNA damage, oxidative protein damage, and cellular senescence induced by oxidative damage. Their data suggest that NF-κB inhibitors can mitigate cellular damage and could provide clinical benefit for degenerative changes caused by aging.

TITLE:

NF-κB inhibition delays DNA damageinduced senescence and aging in mice

AUTHOR CONTACT:

Paul Robbins

University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Phone: (412) 648-9268; Fax: (412) 624-8997; E-mail: probb@pitt.edu

View this article at: http://www.jci.org/articles/view/45785?key=84c4d84388bea61c718c


IMMUNOLOGY
Combatting fungal eye infections

Pathogenic fungal infections of the eye can be difficult to treat and often result in blindness. Sixto Leal, Eric Pearlman, and colleagues at Case Western Reserve University have investigated the cellular warfare occurring between fungi and the immune system during eye infections. They employed mouse model systems to investigate the involvement of neutrophils, the first immune cell type at sites of injury, in controlling fungal infections. Their results showed that neutrophils are critical to contr
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Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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