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JCI early table of contents for July 8, 2013
Date:7/8/2013

Immune cells play a role in early pregnancy

Macrophages are white blood cells that help prevent and alert the immune system to the threat of a pathogenic infection. Interestingly, macrophages are present in the uterus and ovaries at the time of conception. In this issue of the Journal of Clinical Investigation, Sarah Robertson and colleagues at the University of Adelaide investigated the role of macrophages in early pregnancy. The team utilized a mouse model in which macrophages could be depleted immediately after embryo implantation. They found that without macrophages, embryos were unable to implant in the uterus. The failure to implant was thought to be caused by reduced levels of certain hormones, such as progesterone and vascular endothelial growth factors. Pregnancy could be completely restored by either the addition of macrophages or through administration of progesterone. These findings shed light on a new function of macrophages, as well as a potentially correctable cause of infertility.

TITLE:
Macrophages regulate corpus luteum development during embryo implantation in mice

AUTHOR CONTACT:
Sarah Robertson
The University of Adelaide, Adelaide, UNK, AUS
Phone: +618 8303 4094; Fax: +618 8303 4099; E-mail: sarah.robertson@adelaide.edu.au

View this article at: http://www.jci.org/articles/view/60561?key=9221c3260eec6640345e


Removal of tumor-associated immune cell protein decreases tumor progression

The number of tumor-associated immune cells is correlated with poor prognosis in cancer patients. Reducing these cells in mouse models of breast cancer reduces tumor metastasis, indicating that tumor-immune interactions are critical for cancer progression. In this issue of the Journal of Clinical Investigation, Shelley Earp and col
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Contact: Corinne Williams
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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