Navigation Links
JCI early table of contents for July 8, 2013

Immune cells play a role in early pregnancy

Macrophages are white blood cells that help prevent and alert the immune system to the threat of a pathogenic infection. Interestingly, macrophages are present in the uterus and ovaries at the time of conception. In this issue of the Journal of Clinical Investigation, Sarah Robertson and colleagues at the University of Adelaide investigated the role of macrophages in early pregnancy. The team utilized a mouse model in which macrophages could be depleted immediately after embryo implantation. They found that without macrophages, embryos were unable to implant in the uterus. The failure to implant was thought to be caused by reduced levels of certain hormones, such as progesterone and vascular endothelial growth factors. Pregnancy could be completely restored by either the addition of macrophages or through administration of progesterone. These findings shed light on a new function of macrophages, as well as a potentially correctable cause of infertility.

Macrophages regulate corpus luteum development during embryo implantation in mice

Sarah Robertson
The University of Adelaide, Adelaide, UNK, AUS
Phone: +618 8303 4094; Fax: +618 8303 4099; E-mail:

View this article at:

Removal of tumor-associated immune cell protein decreases tumor progression

The number of tumor-associated immune cells is correlated with poor prognosis in cancer patients. Reducing these cells in mouse models of breast cancer reduces tumor metastasis, indicating that tumor-immune interactions are critical for cancer progression. In this issue of the Journal of Clinical Investigation, Shelley Earp and colleagues at the University of North Carolina a Chapel Hill demonstrate that removal of the protein MerTK from immune cells decreased tumor growth in mouse models of breast cancer, melanoma, and colon cancer. Loss of MerTK reduced the release of molecules associated with inflammation. These findings suggest that drugs that inhibit MerTK may stimulate anti-tumor responses and could potentially have clinical benefit.

MerTK inhibition in tumor leukocytes decreases tumor growth and metastasis

Shelton Earp
UNC Lineberger Comp Cancer Center, Chapel Hill, NC, USA
Phone: 919-966-2335; Fax: 919-966-3015; E-mail:

View this article at:


TITLE: LXRβ/estrogen receptor-α signaling in lipid rafts preserves endothelial integrity

AUTHOR CONTACT: Michihisa Umetani
The University of Texas Southwestern Medical Center, Dallas, TX, USA
Phone: 214-648-9180; Fax: 214-648-2096; E-mail:

View this article at:

TITLE: Metastasis-associated PRL-3 induces EGFR activation and addiction in cancer cells

AUTHOR CONTACT: Abdul Qader Omer Al-Aidaroos
A*STAR, Singapore, UNK, SGP
Phone: 65-6586-9883; E-mail:

View this article at:

TITLE: Collagen VII plays a dual role in wound healing

AUTHOR CONTACT: Alexander Nystrom
Albert-Ludwigs University of Freiburg, Freiburg, UNK, DEU
Phone: +49 761 270 67850; E-mail:

View this article at:

TITLE: FGFR2 signaling underlies p63 oncogenic function in squamous cell carcinoma

Massachusetts General Hospital Cancer Center, Boston, MA, USA
Phone: (617)726-4315; Fax: (617)726-8623; E-mail:

View this article at:

TITLE: ARHGDIA mutations cause nephrotic syndrome via defective RHO GTPase signaling

AUTHOR CONTACT: Friedhelm Hildebrandt
HHMI/University of Michigan, Ann Arbor, MI, USA
Phone: 734-615-7285; Fax: 1-734-615 1386; E-mail:

View this article at:


Contact: Corinne Williams
Journal of Clinical Investigation

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. An Early Start for Your Child with Autism
3. Early Study Finds Some Promise for Lung Cancer Vaccine
4. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
5. JCI early table of contents for April 9, 2012
6. Eye Tremors May Aid Early Diagnosis of Parkinsons: Study
7. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
8. First contact: Early intervention key in diagnosis and treatment of serious mental illness
9. Brain Tumor Vaccine Shows Promise in Early Trial
10. Role of Screening, Monitoring in Early Kidney Disease Unclear
11. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
Post Your Comments:
(Date:11/28/2015)... ... November 28, 2015 , ... Safe storage for contraceptive ... two inventors, one from Lakewood, New Jersey and the other from Bradley Beach, New ... PROTECTOR to save the expense of having to replace NuvaRings more often than necessary. ...
(Date:11/27/2015)... , ... November 28, 2015 , ... There is only ... outperform our billings from last year? , This question has not been an easy ... coming to the retirement age and the younger workforce don’t share the same discipline ...
(Date:11/27/2015)... ... November 27, 2015 , ... The rapid speed at which ... age, more care is needed, especially with Alzheimer’s, dementia and other cognitive conditions ... overworked. The forgotten part of this equation: 80 percent of medical care occurs ...
(Date:11/27/2015)... ... November 27, 2015 , ... Lizzie’s Lice Pickers just announced a special ... 10% off of their purchase of lice treatment product. In addition, customers will receive ... a company spokesperson. “Finding lice is a sure way to ruin the holidays, so ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... motto of progress through sharing, the 2016 Building Better Radiology Marketing Programs ... conference will begin on Sunday, March 6, 2016, at Caesars Palace in Las ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... North Carolina , 26 november 2015 ... Inc. (AAIPharma/CML) kondigt de geplande investering aan ... uitbreiding van de laboratoria en het mondiale ... . De uitbreiding zal resulteren in extra ... wordt voldaan aan de groeiende behoeften van ...
(Date:11/26/2015)... , Nederland, November 26, 2015 ... Een nieuwe aanpak combineert immunotherapie met ... kanker. ) ...      (Photo: ) ... Leids Universitair Medisch Centrum (LUMC) ...
(Date:11/26/2015)... 26, 2015 Research and Markets ( ) ... Pacemaker Market Outlook to 2019 - Rise in Cardiac Disorders ... report to their offering. Boston ... Boston scientific and others. --> ... Biotronik, Boston scientific and others. ...
Breaking Medicine Technology: