Navigation Links
JCI early table of contents for July 16, 2012
Date:7/16/2012

ONCOLOGY

A new target in acute myeloid leukemia | Back to top

Acute myeloid leukemia, a common leukemia in adults, is characterized by aberrant proliferation of cancerous bone marrow cells. Activating mutations in a protein receptor known as FLT3 receptor are among the most prevalent mutations observed in acute myeloid leukemias. FLT3 mutants are thought to activate several signaling pathways that contribute to cancer development. Dr. Daniel Tenen and colleagues from Harvard University in Boston discovered a new pathway activated by FLT3 mutation. Their results show that cyclin dependent kinase 1 (CDK1), a critical regulator of cell division is activated in FLT3 mutated leukemias, leading to the activation of downstream gene transcription. Most importantly, they demonstrate that inhibiting CDK1 activity promotes differentiation of cells from patient-derived peripheral blood samples. As clinical trials with CDK1 inhibitors are ongoing, their data strongly suggest that therapies targeting the CDK1 pathway may be efficacious for acute myeloid leukemias with FLT3 mutation, especially in patients resistant to FLT3 inhibitor therapies.

TITLE:

Targeting CDK1 promotes FLT3-activated acute myeloid leukemia differentiation through C/EBPα

AUTHOR CONTACT:

Daniel Tenen

Beth Israel Deaconess Medical Center, Boston, MA, USA

Phone: 617-735-2235; Fax: 617-735-2222; E-mail: dtenen@bidmc.harvard.edu

View this article at: http://www.jci.org/articles/view/43354?key=65aa2f71faac98dd69ed

ONCOLOGY

A remarkably simple genome underlies highly malignant pediatric rhabdoid cancers | Back to top

Cancer is principally considered a genetic disease, and numerous mutations are thought essential to drive its growth. However, the existence of genomica
'/>"/>

Contact: Sarah Jackson
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. New Stool Test Might Aid in Early Detection of Colon Cancer
2. An Early Start for Your Child with Autism
3. Early Study Finds Some Promise for Lung Cancer Vaccine
4. Treat Rheumatoid Arthritis Early and Aggressively: Guidelines
5. JCI early table of contents for April 9, 2012
6. Eye Tremors May Aid Early Diagnosis of Parkinsons: Study
7. Nearly 1 in 4 grandparents store prescription medicines where children can easily find them
8. First contact: Early intervention key in diagnosis and treatment of serious mental illness
9. Brain Tumor Vaccine Shows Promise in Early Trial
10. Role of Screening, Monitoring in Early Kidney Disease Unclear
11. Detecting malaria early to save lives: New optical technique promises rapid and accurate diagnosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... 2014 As reported by the Statesman Journal ... Heroin (7/20), police in Salem, MA as well as ... the recent heroin epidemic that has taken many lives during ... heroin-related overdose case in which police were able to make ... phone. By pretending to be the victim and claiming to ...
(Date:7/25/2014)... 25, 2014 Ticket Down ... board for the Guinness International Champions Cup match between ... at Soldier Field on Sunday, July 27th. ... appreciation promo/coupon/offer code SOCCER-2014 for added savings. , 2014 ... diehard soccer fans in North America. Countless international soccer ...
(Date:7/25/2014)... (HealthDay News) -- Seniors are more easily distracted during ... study finds. "Almost any type of memory test ... of 25 on," study co-author Randi Martin, professor of ... release. However, Martin said, this study shows that ... older adults compared with younger adults. The study ...
(Date:7/25/2014)... 2014 Sport Court® provided ... Nike National Invitational Tournament (NIT) in Chicago ... Junior National Tournament (USJN) in Washington D.C. at ... for these prestigious national tournaments included 44 Sport Court ... of playing surface at McCormick Place for the NIT, ...
(Date:7/25/2014)... Island (PRWEB) July 25, 2014 Reproductive ... to announce that Dr. Kerri Luzzo, Lead Physician at ... Award" for her professional accomplishments in fertility care and ... , At the 10th Annual PBN Awards ceremony held ... Island, 40 of the most highly regarded, emerging leaders ...
Breaking Medicine News(10 mins):Health News:Multiple States Crack Down on Heroin Epidemic 2Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Distractions Seem More Troublesome With Age 2Health News:Sport Court Provides All Sports Flooring for Basketball Events in Chicago and Washington D.C. 2Health News:Dr. Kerri Luzzo of the Reproductive Science Center of Providence Receives “40 Under Forty Award" for Outstanding Professional Accomplishments and Community Outreach 2
... Oct. 9 A diverse coalition of,clergy and ... conference,today to urge U.S. Senators John Warner (R-VA) ... Delegation to support legislation that gives,the U.S. Food ... legislation would protect kids from tobacco and save ...
... Oct. 9 The Oregon Rehabilitation,Association (ORA), ... disabled workers this October with National,Disability Employment Awareness ... each October to help increase the public,s awareness ... to the,entire month of October in 1988. ...
... Mental Retardation -, PHILADELPHIA, Oct. 9 ... a ring before birth, they may,disrupt normal development ... The Children,s Hospital of Philadelphia will be investigating,one ... the Ring Chromosome,20 Foundation., Ring chromosome 20 ...
... October marks National,Domestic Violence Awareness Month and ... States are affected by domestic violence each year. ... Cosmetic Dentistry,Charitable Foundation,s (AACDCF) Give Back A Smile ... life by restoring a smile" by providing,free cosmetic ...
... a University of Iowa Research Foundation licensee and ... age-related macular degeneration (AMD) and other chronic diseases, ... startup financing. , The company, which has offices ... into new facilities at the UI,s Oakdale Research ...
... 9, 2007People who experience chronic job strain after a ... a second one, reports a research team from Universit ... of the Journal of the American Medical Association. , ... risks associated with job strain for workers who have ...
Cached Medicine News:Health News:Virginia Faith Leaders Call on Senators Webb & Warner to Cosponsor Legislation to Protect Kids from Tobacco 2Health News:Virginia Faith Leaders Call on Senators Webb & Warner to Cosponsor Legislation to Protect Kids from Tobacco 3Health News:October Is National Disability Employment Awareness Month 2Health News:Grant Supports Study of Abnormal Ring-Shaped Chromosomes 2Health News:600 Smiles Restored Thanks to the AACDCF's Give Back A Smile Program - October Marks National Domestic Violence Awareness Month 2Health News:UI licensee Optherion secures $37 million in financing 2Health News:UI licensee Optherion secures $37 million in financing 3Health News:UI licensee Optherion secures $37 million in financing 4Health News:Chronic job strain doubles the risk of a second heart attack 2
(Date:7/25/2014)... July 25, 2014  CVS Caremark Corporation (NYSE: ... on Tuesday, August 5, 2014, at 8:30 a.m. (EDT) ... 2014 financial results. An audio webcast of ... Investor Relations portion of the CVS Caremark website for ... http://info.cvscaremark.com/investors . This webcast will be archived and available ...
(Date:7/25/2014)... N.J. , July 25, 2014  Acsis ... brand protection and serialization solutions, has recently posted ... that addresses current and future needs for ... for the old supply chain model no longer ... in technology, including the growth of mobile technology, ...
(Date:7/25/2014)... , July 25, 2014 Research ... "Global Ophthalmic Diagnostic Devices Market 2014-2018" report ... About Ophthalmic Diagnostic Device ... used to identify a defect or deficiency in the ... with ophthalmic disorders such as presbyopia, cataracts, glaucoma, retinal ...
Breaking Medicine Technology:Acsis Addresses Questions on the Modern Supply Chain 2Global Ophthalmic Diagnostic Devices Market 2014-2018: Key Vendors are Alcon, Carl Zeiss, Haag-Streit and Topcon 2
... Filtrona Porous Technologies, a developer and manufacturer of ... world, will introduce a new range of hydrophilic, polyurethane ... / COMPAMED trade fair in Dusseldorf, Germany from 16 ... ) New innovations to be featured ...
... Nordisk, a world leader in diabetes care, announced today that ... (DHF), a non-profit organization that raises diabetes awareness ... the success of the Drive the Switch program, which has ... loved ones and their doctor about options for insulin delivery, ...
Cached Medicine Technology:Filtrona Porous Technologies to Introduce New Hydrophilic Foam Products for Advanced Wound Care at the MEDICA / COMPAMED Trade Fair 2Novo Nordisk Donates $50,000 to Diabetes Hands Foundation in Recognition of the Drive the Switch Program's Inaugural Year 2Novo Nordisk Donates $50,000 to Diabetes Hands Foundation in Recognition of the Drive the Switch Program's Inaugural Year 3Novo Nordisk Donates $50,000 to Diabetes Hands Foundation in Recognition of the Drive the Switch Program's Inaugural Year 4Novo Nordisk Donates $50,000 to Diabetes Hands Foundation in Recognition of the Drive the Switch Program's Inaugural Year 5Novo Nordisk Donates $50,000 to Diabetes Hands Foundation in Recognition of the Drive the Switch Program's Inaugural Year 6Novo Nordisk Donates $50,000 to Diabetes Hands Foundation in Recognition of the Drive the Switch Program's Inaugural Year 7
The ThermaViewer™ is constructed and engineered for use in laboratories, hospitals, and commercial kitchens to monitor and document freezer and refrigerator temperatures where inventory is store...
... This requiring no water ... long-lasting hand hygiene to physically ... washing is either not an ... Hibistat allows you to return ...
Amino+Derm moisturizers and soaps are specifically engineered to aid in the prevention of skin irritations and to help maintain healthy, intact skin....
... Scrub Care povidone-iodine (PVP-I) antimicrobial solutions ... control in all hospital and health-care settings. ... gel have a broad spectrum of activity, ... bacteria that may cause infection. The new ...
Medicine Products: