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JCI early table of contents for Jan. 25, 2013
Date:1/25/2013

rative Diseases (DZNE) & TUM, Munich, UNK, DEU
Phone: +498970958416; E-mail: stefan.lichtenthaler@dzne.lmu.de

View this article at: http://www.jci.org/articles/view/67548?key=1a92eca12fdd73f8da76


Rooting out hormone refractory prostate cancer

Prostate cancer is one of the most common malignancies in men. It is highly treatable in early stages; however, once the cancer becomes metastatic, it cannot be cured. In this issue of the Journal of Clinical Investigation, Fillippo Giancotti and colleagues at Memorial Sloan-Kettering Cancer Center in New York, demonstrate that a significant fraction of advanced, hormone refractory prostate cancers express high levels of the protein β4 integrin. Using a mouse model of prostate cancer, Giancotti and colleagues found that loss of the β4 integrin gene significantly inhibited prostate tumor growth and progression by blocking activation of the oncogenic proteins ErbB2 and c-Met, which are responsible for sustaining prostate cancer stem cells. In a companion commentary Max Wicha of the University of Michigan discusses how targeting of these proteins could be a useful therapeutic strategy for the treatment of advanced prostate cancer.

TITLE:
β4 Integrin signaling induces expansion of prostate tumor progenitors

AUTHOR CONTACT:
Filippo Giancotti
MSKCC, New York, NY, USA
Phone: 212-639-6998; Fax: 212-794-6236; E-mail: f-giancotti@ski.mskcc.org

View this article at: http://www.jci.org/articles/view/60720?key=5d9712f139a9b198e261

ACCOMPANYING COMMENTARY

TITLE:
B4 Androgen ablation: Attacking the prostate cancer stem cell


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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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