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JCI early table of contents for Jan. 25, 2013
Date:1/25/2013

f Physcians and Surgeons, New York, NY, USA
Phone: 212 305-1306; Fax: 212 305-6443; E-mail: hjw14@columbia.edu

View this article at: http://www.jci.org/articles/view/67454?key=9e95d8d9835bfa8639b5

Green tea and Vardenafil: a killer chemotherapy combo

Several recent studies have demonstrated that EGCG, a major constituent of green tea, has anti-cancer properties, but the molecular mechanisms underlying its effects are unknown. In this issue of the Journal of Clinical Investigation, Hirofumi Tachibana and colleagues at Kyushu University in Fukuoka, Japan, demonstrate that EGCG activates the 67-kDa laminin receptor, which elevates intracellular levels of the molecule cGMP to induce cell death. Tachibana and colleagues combined EGCG with vardenafil, a drug used to treat erectile dysfunction, which blocks the activity of PDE5, a protein that degrades cGMP. In a mouse model of multiple myeloma, vardenafil potentiated the effects of EGCG to mediate cancer cell death. Chung Yan and Hong Wang of Rutgers University discuss these findings in a companion commentary.

TITLE:
67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis

AUTHOR CONTACT:
Hirofumi Tachibana
Kyushu University, Fukuoka, JPN
Phone: +81-92-642-3008; E-mail: tatibana@agr.kyushu-u.ac.jp

View this article at: http://www.jci.org/articles/view/64768?key=230ac8bcfd7fc9e49bd2

ACCOMPANYING COMMENTARY

TITLE:
Cancer therapy combination: Green tea and a phosphodiesterase 5 inhibitor?

AUTHOR CONTACT:
Chung S Yang
Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, Piscataw
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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