Navigation Links
JCI early table of contents for Jan. 25, 2013

f Physcians and Surgeons, New York, NY, USA
Phone: 212 305-1306; Fax: 212 305-6443; E-mail:

View this article at:

Green tea and Vardenafil: a killer chemotherapy combo

Several recent studies have demonstrated that EGCG, a major constituent of green tea, has anti-cancer properties, but the molecular mechanisms underlying its effects are unknown. In this issue of the Journal of Clinical Investigation, Hirofumi Tachibana and colleagues at Kyushu University in Fukuoka, Japan, demonstrate that EGCG activates the 67-kDa laminin receptor, which elevates intracellular levels of the molecule cGMP to induce cell death. Tachibana and colleagues combined EGCG with vardenafil, a drug used to treat erectile dysfunction, which blocks the activity of PDE5, a protein that degrades cGMP. In a mouse model of multiple myeloma, vardenafil potentiated the effects of EGCG to mediate cancer cell death. Chung Yan and Hong Wang of Rutgers University discuss these findings in a companion commentary.

67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis

Hirofumi Tachibana
Kyushu University, Fukuoka, JPN
Phone: +81-92-642-3008; E-mail:

View this article at:


Cancer therapy combination: Green tea and a phosphodiesterase 5 inhibitor?

Chung S Yang
Ernest Mario School of Pharmacy at Rutgers, The State University of New Jersey, Piscataw

Contact: Jillian Hurst
Journal of Clinical Investigation

Page: 1 2 3 4 5 6 7 8 9

Related medicine news :

1. Dont ignore the snore: Snoring may be early sign of future health risks
2. NIH-developed candidate dengue vaccine shows promise in early-stage trial
3. Nearly half of children under 2 years of age receive some vaccinations late
4. Study Finds Nearly Half of U.S. Kids Are Under-Vaccinated
5. JCI early table of contents for Jan. 16, 2013
6. Generic HIV treatment strategy could save nearly $1 billion annually but may be less effective
7. Early Parkinsons Patients May Suffer Some Symptoms in Silence
8. Early Ovary Removal May Be Tied to Lapses in Memory, Thinking
9. Fox Chase researchers discover novel role of the NEDD9 gene in early stages of breast cancer
10. Depressed Stroke Survivors May Face Higher Early Death Risk
11. Teenagers with a low muscular strength have a higher risk of dying early form heart disease
Post Your Comments:
(Date:7/29/2014)... Denver, CO (PRWEB) July 29, 2014 ... review that this actually is a new method of ... , The author of the new method ensure sufferers ... undergo the right recommendations. , The new method ... help sufferers completely overcome sciatica with an 8 minutes ...
(Date:7/29/2014)... Winter is here down under, and ... Sydney’s central business district. That is, until a troop ... the otherwise ordinary day into a celebration—a celebration of ... advocates of The Truth About Drugs, a drug prevention ... They woke up the city with a rousing performance ...
(Date:7/29/2014)... Australia (PRWEB) July 30, 2014 ... of medical devices have determined Nurse Call Systems ... international legislation, this requires all Nurse Call Systems ... regulatory practice improves patient safety, reduces clinical risks, ... private hospital based Corporate Risk and Clinical Risk ...
(Date:7/29/2014)... (PRWEB) July 29, 2014 Daily Gossip writes ... powerful and holistic system that will teach users how to ... by thousands of people, from all over the world. ... symptoms of this disorder in as quickly as 12 hours. ... gone faster than imagined. , The Fibroids Miracle review ...
(Date:7/29/2014)... 29, 2014 Regardless of the good ... special someone to share those with. Love is about ... , Love is also about overcoming all the ... have that perfect relationship, women need to know how ... the Enchant Him program, please visit the official website ...
Breaking Medicine News(10 mins):Health News:Stop Sciatica in 8 Minutes Review Reveals the Way to Cure Sciatica Easily 2Health News:Sydney Business District “Rocked” by The Truth About Drugs 2Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 2Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 3Health News:NiQ Health Reveals the Extensive Use of Unregulated Medical Devices in Australian Hospitals 4Health News:Amanda Leto’s Fibroids Miracle Review Reveals Clinically Proven Uterine Fibroids Cure System 2Health News:How to Reach the Heart of the Perfect Guy with "Enchant Him Program" - a Report by Daily Gossip Magazine 2
... the world. It can lead to strokes, heart attacks and ... half an hour and an hour of moderate exercise on ... heart disease, cancer, diabetes and obesity.,Researchers from Japan, tested 207 ... otherwise healthy. None exercised regularly. ,They divided them into ...
... before it's in a more advanced stage is key to ... early lung cancer, researchers wanted to determine if it is ... wanted to look at the cost-effectiveness of a CT scan ... the Early Lung Cancer Action Project (ELCAP) that was conducted ...
... significantly improve memory.,New research shows a centuries-old herbal remedy ... ,A team of researchers tested 44 healthy, young ... sage oil capsules, and some were given placebos. In ... oil performed significantly better than those who didn't. ...
... crippling as depression can be for young and middle-age ... often fatal.// And while depression and related illnesses afflict ... getting the treatment they need. ,"Depression kills not ... research at the National Institute of Mental Health. "[Elderly] ...
... American and German researchers say they've developed a new ... // ,They've developed a radio-isotope that emits far more ... metastases that are formed when tumor cells invade bone ... control bone pain in people with bone metastases. ...
... new study shows the best time to make a prognosis ... Researchers find cell counts //at that time give a more ... originally diagnosed with HIV. ,Highly active antiretroviral therapy (HAART) ... the prognosis of HIV patients, however there is not a ...
Cached Medicine News:
(Date:7/29/2014)...  Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ) ... conferences during the third quarter, the 2014 Avondale Partners ... 2014 Conference.  Alexza,s corporate presentation will be webcast live ... event are below: , 2014 Avondale Partners ... Boston , MA.  The format is limited ...
(Date:7/29/2014)... ROCKVILLE, Md. , July 29, 2014  Synthetic ... anti-infective biologic and drug candidates targeting specific pathogens that ... view of the unusual market activity in the Company,s ... Company in accordance with its usual practice. The Company ... unusual market activity. About Synthetic Biologics, Inc. ...
(Date:7/29/2014)... Conn. , July 29, 2014 Numotion,s Board ... Mike Swinford will be the company,s new Chief ... highly successful 22-year career at GE where he worked primarily ... in annual revenue to over $5 billion. His most recent ... Services. "I am thrilled to join Numotion," ...
Breaking Medicine Technology:Alexza Pharmaceuticals Announces Participation in Upcoming Investor Conferences 2Alexza Pharmaceuticals Announces Participation in Upcoming Investor Conferences 3Synthetic Biologics, Inc. States that Its Policy is Not to Comment on Unusual Market Activity 2Numotion Names Mike Swinford CEO 2
... DrDrugs®: Drug Guide for ... over 760 Integrated Calculators ... comprehensive, up-to-date and practical ... in drug dosing calculation ...
DRUGology is a source designed for primary care health providers, residents and medical students so that they may have a quick reference to treat a wide variety of conditions....
AnesthesiaDrugs™ is the handheld version of Sota Omoigui's Anesthesia Drugs Handbook, the best selling clinical guide to essential anesthesia and critical care drug information....
... extensive evidence-based data than any other drug reference., ... as it's come to be known, has gone ... seeking answers to the most detailed questions. It ... drug reference and is now available for your ...
Medicine Products: