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JCI early table of contents for Jan. 25, 2013
Date:1/25/2013

Prostate cancer cells thrive on stress

Prostate cancer patients have increased levels of stress and anxiety; however, several recent studies have found that men who take drugs that interfere with the stress hormone adrenaline have a lower incidence of prostate cancer. In this issue of the Journal of Clinical Investigation George Kulik and colleagues at Wake Forest University examined the relationship between stress and cancer progression in a mouse model of prostate cancer. Kulik and colleagues found that mice that had been subjected to stress (exposed to the scent of a predator) exhibited a significantly reduced response to a drug that induces cancer cell death compared to their unstressed counterparts. Administration of adrenaline also blocked cancer cell death. Conversely, drugs that inhibited adrenaline signaling ablated the effect of stress on prostate cancer. These findings suggest that beta-blockers, which are used for the treatment of high blood pressure and block the effects of adrenaline, could increase the efficacy of anti-cancer therapies. In a companion commentary, Anil Sood and colleagues at MD Anderson Cancer Center discuss additional studies that will be required to move these findings from bench to bedside.

TITLE:
Behavioral stress accelerates prostate cancer development in mice

AUTHOR CONTACT:
George Kulik
Wake Forest University Health Sciences, Winston-Salem, NC, USA
Phone: 336-713-6750; E-mail: gkulik@wakehealth.edu

View this article at: http://www.jci.org/articles/view/63324?key=6ae78db845f6f7d9379b

ACCOMPANYING COMMENTARY

TITLE:
Why stress is BAD for cancer patients

AUTHOR CONTACT:
Anil Sood
M. D. Anderson Cancer Center, Houston, TX, USA
Phone: 713-745-5266; Fax: 713-792-7586; E-mail:

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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