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JCI early table of contents for Jan. 2, 2013
Date:1/2/2013

mage is thought to be caused by immune system-mediated inflammation; however, other demyelinating disorders, such as Pelizaeus-Merzbacher disease, do not involve the immune system, suggesting that there are other causes of retinal nerve damage. Deimination is a protein modification that is altered in patients with MS and PMD. In this issue of the Journal of Clinical Investigation, researchers led by Sanjoy Bhattacharya at the University of Miami investigated the role of deimination in retinal nerve damage in a mouse model of demyelinating disease (ND4 mice). They found that deimination was reduced in patients with demyelinating diseases and in ND4 mice that exhibited vision loss. Decreases in deamination could be detected in the mice prior to the onset of other symptoms. Bhattacharya and colleagues found that they could improve visual function in ND4 mice by restoring deimination. These results demonstrate that loss of deimination underlies nerve damage in demyelinating diseases and may be a suitable target for therapeutic intervention.

TITLE:
Deimination restores inner retinal visual function in murine demyelinating disease

AUTHOR CONTACT:
Sanjoy Bhattacharya
University of Miami Miller School of Medicine, Miami, FL, USA
Phone: 3054824103; Fax: 3053266547; E-mail: sbhattacharya@med.miami.edu

View this article at: http://www.jci.org/articles/view/64811?key=1cb7e7315edf5b9d1258


ALSO IN THIS ISSUE

TITLE:
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice

AUTHOR CONTACT:
Nicoletta Filigheddu
University of Piemonte Orientale "A. vogadro", Novara, ITA
Phone: +390321660529; E-mail: nicoletta.filigheddu@med.unipmn.it

View this article at:

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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