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JCI early table of contents for Jan. 16, 2013
Date:1/16/2013

OMPANYING ARTICLE:

TITLE:
Clash of the microbes: let's bring back the good guys

AUTHOR CONTACT:
Judith Aberg
New York University School of Medicine, New York, NY, USA
Phone: 2122637300; E-mail: judith.aberg@nyumc.org

View this article at: http://www.jci.org/articles/view/66736?key=64b158b04e2a168811a3


Hepatitis B virus promotes oncogenesis through microRNA modulation

Viruses prompt oncogenic transformation by genetically altering infected cells. Several recent studies have demonstrated that viruses alter the expression of microRNAs, non-coding RNA molecules that can block the expression of target genes. In this issue of the Journal of Clinical Investigation, Xiaoje Xu and colleagues at the Beijing Institute of Biotechnology report that miR-148a is repressed by hepatitis B virus (HBV) X protein (HBx) to promote growth and metastasis of liver cancer. In normal liver cells, miR-148a represses the expression of the oncogenic protein HPIP, but the hepatitis B virus prevents expression of miR-148a, leading to increased levels of HPIP and subsequent oncogenic transformation. This study demonstrates that a cancer-associated virus promotes carcinogenesis through direct manipulation of a microRNA.

TITLE:
Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis

AUTHOR CONTACT:
Qinong Ye
Beijing Institute of Biotechnology, Beijing, CHN
Phone: (8610)68180809; Fax: (8610)68248045; E-mail: yeqn66@yahoo.com

View this article at: http://www.jci.org/articles/view/64265?key=267b145ad442aacf5c02


ALSO IN THIS ISSUE

Osteoclast-specific cathepsin K deletion stimulates S1P-d
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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