Navigation Links
JCI early table of contents for Feb. 8, 2013
Date:2/8/2013

Rooting out recurrent breast cancer

Due to chemotherapy resistance and a high rate of relapse, triple negative cancers are among the most difficult breast cancers to treat. In this issue of the Journal of Clinical Investigation, researchers led by Carlos Arteaga at Vanderbilt University identified a protein, TGF-β, that is highly expressed in triple negative breast cancer cells after chemotherapy. In a mouse model of breast cancer, TGF-β both diverted cells down a path to becoming cancerous and allowed for cancer to come back after treatment. Importantly, loss of TGF-β prevented tumor recurrence in mice. These studies identify a mechanism by which cancer cells elude standard chemotherapy and provide a rationale for testing the therapeutic potential of agents that block TGF-β.

TITLE:
TGFβ inhibition enhances chemotherapy action against triple negative breast cancer

AUTHOR CONTACT:
Carlos Arteaga
Vanderbilt University, Nashville, TN, USA
Phone: 615-936-3524; Fax: 615-936-1790; E-mail: carlos.arteaga@vanderbilt.edu

View this article at: http://www.jci.org/articles/view/65416?key=201b874c7a54cc627c43


Targeting T cells in rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune disorder in which immune cells attack the joints, causing inflammation, swelling, and erosion. Specific sets of immune cells, known as T cells, are responsible for inducing disease. In this issue of the Journal of Clinical Investigation, researchers led by Harvey Cantor at Harvard University analyzed the contributions of different subsets of T cells to an RA-like condition in mice. Cantor and colleagues identified a subset of regulatory T cells (CD8+ Tregs) that can remove pathogenic T cell subsets and inhibit
'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Students in Educational First Steps Assisted Centers Show Persistent Benefits Far Beyond Early Childhood According to University of Texas at Dallas Study
2. Exposure to Smog in Early Pregnancy Linked to Complications
3. Mayo Clinic-led study identifies biomarkers for early risk assessment of acute kidney injury
4. Mammogram every 2 years has same benefit as yearly mammogram for older women, UCSF study finds
5. Early breast cancer diagnosis, survival rates low in rural India
6. JCI early table of contents for Feb. 1, 2013
7. Bioelectric signals can be used to detect early cancer
8. Blacks Less Likely to Receive Kidney Transplant Early On, Study Finds
9. Belly Fat May Raise Odds of Early Death for Thin Heart Patients
10. Sugar Addict Claims Americans Consuming 150 lbs of Sugar Yearly
11. New OHSU research helps explain early-onset puberty in females
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/23/2014)... Athens, GA (PRWEB) August 23, 2014 Young adults ... drinking or doing drugs should pick up the phone and call ... troubled teen drug addict . , Troubled Teen Athens ... who is ready to finally take the necessary steps to end ... help, they are quick to go to friends or peers when ...
(Date:8/23/2014)... Springs, NC (PRWEB) August 23, 2014 Teen ... facing young people in Holly Springs, NC. Countless adolescents throughout ... a regular basis. Unfortunately, many never receive professional rehab ... young adults on where to get help. Troubled Teens Holly ... in the lives of local teenage alcohol abusers ...
(Date:8/22/2014)... Texas (PRWEB) August 23, 2014 ... Industry” is a professional and in-depth research report ... basic Glucose Meter information, including Glucose Meter definition, ... as industry overview. This research covers the international ... global industry analysis covering macroeconomic environment & economic ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 AWeber, ... services that currently helps more than 120,000 small ... caught the attention of Shane Michaels, prompting an investigative ... crucial element for any online marketing campaign, despite what ... in the marketing world,” reports Michaels. “AWeber is a ...
(Date:8/22/2014)... 23, 2014 This report studies ... Liquid Handling Systems), Consumables (Tubes), Kits (Isolation, Purification), ... Diagnostics) - Global Forecast to 2018" This market ... is poised to grow at a CAGR of ... million by 2018. , Browse 98 market data ...
Breaking Medicine News(10 mins):Health News:Teenagers in Athens, GA are Locating Addiction Recovery Thanks to New Helpline 2Health News:New Helpline Provides Teen Drug & Alcohol Recovery Information in Holly Springs, NC 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:AWeber: Review Exposes Affordable Provider of Opt-In Email Marketing Services 2Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 2Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 3Health News:Sample Preparation Market by Product and Application Worth $5,672 Million by 2018 - New Research Report by MarketsandMarkets 4
... Scientists have identified the receptor in cells of the peripheral ... to sense cold. ,The finding, reported on-line ... the key mechanisms by which the body detects temperature sensation. ... mediates how the body experiences intense stimuli temperature, in ...
... (FDA) today approved Torisel (temsirolimus) for the treatment of a ... carcinoma. Torisel was approved based on a study that ... renal cell carcinoma. The drug is an enzyme inhibitor, a ... ,'We have made significant advances in the battle ...
... is only a pretext for multinational corporations to take control ... in US charge. With sales of over $35 billion ... it takes to buy up pristine springs in some of ... Nestl, which controls one-third of the U.S. market and sells ...
... combined with sulphur to improve its overall strength and durability. ... to reform and reuse old tyres. The only way ... a process that releases heavy metals and other pollutants and ... and colleagues at Swansea University, UK, have shown that spinning ...
... will have a new -- virtually pain free -- ... Health System (SJMHS) announced today it will begin treating ... Wednesday, June 6th. ,This advanced radiosurgery system ... previously inoperable tumors, with astounding accuracy and with little ...
... to emergency needs and low donor turnout. The American Red ... can, to donate blood. ,As of this ... Red Cross had no units of Type O-negative -- the ... below a one-day supply. ,Shortages of Type O-negative ...
Cached Medicine News:Health News:Detecting Cold, Feeling Pain: Study Reveals Why Menthol Fresh 2Health News:Detecting Cold, Feeling Pain: Study Reveals Why Menthol Fresh 3Health News:FDA: New Drug for Advance Kidney Cancer 2Health News:Multinationals Exploit Groundwater Sources, and People Suffer 2Health News:Multinationals Exploit Groundwater Sources, and People Suffer 3Health News:Multinationals Exploit Groundwater Sources, and People Suffer 4Health News:Multinationals Exploit Groundwater Sources, and People Suffer 5Health News:Advanced Cancer Treatment Brings New Hope to Michigan Patient 2
(Date:8/21/2014)... Conn. , Aug. 21, 2014  Aptuit ... West Lafayette, Indiana , has enhanced ... and characterization of small and large molecules, including ... of the Bruker maXisPlus Q-TOF mass spectrometer. ... Goldman , CEO, Aptuit, said, "The expanded large ...
(Date:8/21/2014)... Texas , Aug. 21, 2014  eRelevance ... services company, announced today that it has completed ... (EMR) solution for Plastic Surgery and Dermatology practices. ... even more value to healthcare practices using Nextech," ... of eRelevance Corporation. "Using information from the EMR ...
(Date:8/21/2014)... 21, 2014 /CNW/ - The Canadian Epilepsy Alliance (CEA) is ... designed to educate children about the most common neurological disorder ... Explain Epilepsy comic series tells a fictional story based ... school while living with epilepsy. "Despite the ... still so much misinformation and lack of awareness out there," ...
Breaking Medicine Technology:Aptuit SSCI Adds Ultra High Resolution Q-TOF Mass Spectrometer for Large & Small Molecule Analyses 2eRelevance Corporation Integrates with Nextech Electronic Medical Records 2Action Heroes Harness Powers to Educate Children About Epilepsy 2Action Heroes Harness Powers to Educate Children About Epilepsy 3
... January 5, 2012 Orthopedic Implants are medical ... injured or troubled joints. Bone is the basic element of ... and assists in movement. Humans commonly suffer from physical fractures, ... or humerus. Treatment of these fractures often requires surgery to ...
... SAN DIEGO, Jan. 5, 2012 Cardium Therapeutics (NYSE Amex: ... entered into its first international agreement for the commercialization ... Cardium entered into a marketing and distribution agreement with ... Korea, for the commercialization of Excellagen Formulated Fibrillar Collagen ...
Cached Medicine Technology:Narang Medical Introduces NET Multifix Nails: Same Nail That Can be Used for Right and Left Legs 2Cardium Announces First International Marketing and Distribution Agreement for Commercialization of Excellagen™ in South Korea 2Cardium Announces First International Marketing and Distribution Agreement for Commercialization of Excellagen™ in South Korea 3Cardium Announces First International Marketing and Distribution Agreement for Commercialization of Excellagen™ in South Korea 4Cardium Announces First International Marketing and Distribution Agreement for Commercialization of Excellagen™ in South Korea 5Cardium Announces First International Marketing and Distribution Agreement for Commercialization of Excellagen™ in South Korea 6
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: