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JCI early table of contents for Feb. 22, 2013
Date:2/22/2013

ions that distinguish pancreatic beta cells from alpha cells. Additionally, Kaestner and colleagues found that they could reprogram alpha cells to function as beta cells by mimicking the epigenetic modifications found in beta cells through treatment with a drug known as a histone methyltransferase inhibitor. These studies suggest that epigenetic manipulation could be used to generate replacement cells for diseases such as diabetes, in which patients lack functional beta cells. In a companion commentary, Larry Moss of Duke University discusses how these cells might serve as an important resource in both research and therapeutic development.

TITLE:
Epigenomic plasticity enables human pancreatic α- to β-cell reprogramming

AUTHOR CONTACT:
Klaus Kaestner
University of Pennsylvania, Perelman School of Medicine, Philadeplhia, PA, USA
Phone: 215.898.8759; Fax: 215.573.5892; E-mail: kaestner@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/66514?key=e4b199f5a3826369a938

ACCOMPANYING COMMENTARY

TITLE:
Creating new beta cells: Cellular transmutation by genomic alchemy

AUTHOR CONTACT:
Larry G. Moss
Duke University Medical Center, Durham, NC, USA
Phone: 617-479-2310; E-mail: larry.moss@duke.edu

View this article at: http://www.jci.org/articles/view/68348?key=11aa06302a250850c4ef


Brain "clean-up crew" captured by MRI

All parts of the body generate waste that must be flushed out in order to remove harmful materials, old proteins, and other cellular detritus. Most tissues utilize the lymphatic system to keep clean, b
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Contact: Jillian Hurst
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Journal of Clinical Investigation
Source:Eurekalert

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