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JCI early table of contents for Feb. 22, 2013
Date:2/22/2013

Dean Sheppard of the University of California, San Francisco, discusses the feasibility of using ROCK inhibitors in a clinical setting.

TITLE:
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

AUTHOR CONTACT:
Yong Zhou
University of Alabama at Birmingham, Birmingham, AL, USA
Phone: 2059752216; E-mail: yzhou@uab.edu

View this article at: http://www.jci.org/articles/view/66700?key=1e6504f3d5e43afe19fb

ACCOMPANYING THE ATTENDING PHYSICIAN

TITLE:
ROCKing pulmonary fibrosis

AUTHOR CONTACT:
Dean Sheppard
UCSF, San Francisco, CA, USA
Phone: 415-514-4269; Fax: 415-514-4278; E-mail: dean.sheppard@ucsf.edu

View this article at: http://www.jci.org/articles/view/68417?key=3482e828788968b30192


Epigenetic alterations reprogram pancreatic cells to secrete insulin

Epigenetic modification is a change to gene expression or cellular phenotype that is caused by alterations that don't involve the underlying DNA sequence. Because all cells in your body contain the exact same genes, these epigenetic changes help determine which genes different cells express, allowing them to develop specialized functions. The pancreas consists of insulin-secreting beta cells and glucagon-secreting alpha cells. Insulin serves as a signal for cells in the body to take up glucose, while glucagon opposes this effect; malfunction of these cells leads to the development of diabetes. In this issue of the Journal of Clinical Investigation, Klaus Kaestner and colleagues at the University of Pennsylvania identified epigenetic modificat
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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