Navigation Links
JCI early table of contents for Feb. 22, 2013
Date:2/22/2013

How to mend a broken heart: advances in parthenogenic stem cells

Parthenogenesis is a form of asexual reproduction during which unfertilized eggs begin to develop as if they had been fertilized. It occurs naturally in many plants and a few invertebrate (some bees, scorpions, parasitic wasps) and vertebrate animals (some fish, reptiles, and amphibians), but does not occur naturally in mammals. In 2007, researchers were able to chemically induce human egg cells to undergo parthenogenesis. The resulting parthenogenote has properties similar to an embryo, but cannot develop further. In this issue of the Journal of Clinical Investigation, Wolfram Zimmerman and colleagues at Georg-August-Universitt Gttingen in Gttingen, Germany, demonstrated that cells from the parthenogenote function as embryonic stem cells and maintain the capacity to develop into different types of tissue. Further, they used parthenogenic stem cells to make cardiomyocytes and engineered heart muscle (myocardium) that exhibited the structural and functional properties of normal myocardium. The engineered myocardium could then be used to engraft the mice that had contributed the eggs for parthenogenesis. These studies demonstrate that parthenogenic stem cells can be used for tissue engineering. In a companion commentary, Michael Schneider of the Imperial College of London discusses how these findings could impact the development of cell replacement therapies.

TITLE:
Parthenogenetic stem cells for tissue engineered heart repair

AUTHOR CONTACT:
Wolfram Zimmermann
Georg-August-Universitt Gttingen, Gttingen, DEU
Phone: +49 (0) 551 39-57 81; E-mail: w.zimmermann@med.uni-goettingen.de

View this article at: http://www.jci.org/articles/view/66854?key=31d6143cd2894a5b80d5

ACCOMPANYING COMMENTARY

TITLE:
Virgin birth: engineered heart muscle from parthenogenic stem cells

AUTHOR CONTACT:
Michael D. Schneider
Imperial College London, London, UNK, GBR
Phone: 011 44 20 7594 3027; Fax: 011 44 20 7594 3190; E-mail: m.d.schneider@imperial.ac.uk

View this article at: http://www.jci.org/articles/view/67961?key=a07301e0e8f34e261854


Pulmonary fibrosis: between a ROCK and a hard place

Pulmonary fibrosis is a scarring or thickening of the lungs that causes shortness of breath, a dry cough, fatigue, chest discomfort, weight loss, a decrease in the ability of the lungs to transmit oxygen to the blood stream, and, eventually, heart failure. Cells known as myofibroblasts normally secrete materials that are required for wound healing; once the wound has closed, the cells disappear. In pulmonary fibrosis, the myofibroblasts stick around, continuing to secrete wound healing factors that cause fibrosis in the lungs. In this issue of the Journal of Clinical Investigation, Yong Zhou and colleagues at the University of Alabama at Birmingham identified a mechanosensitive cellular signaling pathway in myofibroblasts that is activated by the hardening of tissue that has become fibrotic. Activation of this pathway promotes myofibroblast survival and prevents the normal disappearance of these cells after completion of wound healing. The pathway is dependent on a protein known as ROCK. Zhou and colleagues found that a drug that inhibits ROCK, fasudil, attenuates the pro-survival pathway and causes myofibroblasts to die. Further, fasudil treatment protected mice from injury-induced lung fibrosis. These studies suggest that ROCK inhibitors could be used to treat pulmonary fibrosis. In a companion Attending Physician article, Dean Sheppard of the University of California, San Francisco, discusses the feasibility of using ROCK inhibitors in a clinical setting.

TITLE:
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis

AUTHOR CONTACT:
Yong Zhou
University of Alabama at Birmingham, Birmingham, AL, USA
Phone: 2059752216; E-mail: yzhou@uab.edu

View this article at: http://www.jci.org/articles/view/66700?key=1e6504f3d5e43afe19fb

ACCOMPANYING THE ATTENDING PHYSICIAN

TITLE:
ROCKing pulmonary fibrosis

AUTHOR CONTACT:
Dean Sheppard
UCSF, San Francisco, CA, USA
Phone: 415-514-4269; Fax: 415-514-4278; E-mail: dean.sheppard@ucsf.edu

View this article at: http://www.jci.org/articles/view/68417?key=3482e828788968b30192


Epigenetic alterations reprogram pancreatic cells to secrete insulin

Epigenetic modification is a change to gene expression or cellular phenotype that is caused by alterations that don't involve the underlying DNA sequence. Because all cells in your body contain the exact same genes, these epigenetic changes help determine which genes different cells express, allowing them to develop specialized functions. The pancreas consists of insulin-secreting beta cells and glucagon-secreting alpha cells. Insulin serves as a signal for cells in the body to take up glucose, while glucagon opposes this effect; malfunction of these cells leads to the development of diabetes. In this issue of the Journal of Clinical Investigation, Klaus Kaestner and colleagues at the University of Pennsylvania identified epigenetic modifications that distinguish pancreatic beta cells from alpha cells. Additionally, Kaestner and colleagues found that they could reprogram alpha cells to function as beta cells by mimicking the epigenetic modifications found in beta cells through treatment with a drug known as a histone methyltransferase inhibitor. These studies suggest that epigenetic manipulation could be used to generate replacement cells for diseases such as diabetes, in which patients lack functional beta cells. In a companion commentary, Larry Moss of Duke University discusses how these cells might serve as an important resource in both research and therapeutic development.

TITLE:
Epigenomic plasticity enables human pancreatic α- to β-cell reprogramming

AUTHOR CONTACT:
Klaus Kaestner
University of Pennsylvania, Perelman School of Medicine, Philadeplhia, PA, USA
Phone: 215.898.8759; Fax: 215.573.5892; E-mail: kaestner@mail.med.upenn.edu

View this article at: http://www.jci.org/articles/view/66514?key=e4b199f5a3826369a938

ACCOMPANYING COMMENTARY

TITLE:
Creating new beta cells: Cellular transmutation by genomic alchemy

AUTHOR CONTACT:
Larry G. Moss
Duke University Medical Center, Durham, NC, USA
Phone: 617-479-2310; E-mail: larry.moss@duke.edu

View this article at: http://www.jci.org/articles/view/68348?key=11aa06302a250850c4ef


Brain "clean-up crew" captured by MRI

All parts of the body generate waste that must be flushed out in order to remove harmful materials, old proteins, and other cellular detritus. Most tissues utilize the lymphatic system to keep clean, but the central nervous system (CNS) does not have lymphatic vasculature and relies instead on a waste clearance pathway known as the glymphatic system. The glymphatic system cleans the cerebrospinal fluid (CSF) that surround the brain and spinal cord and relies on specialized CNS support cells known as glia. In this issue of the Journal of Clinical Investigation, researchers led by Helene Benveniste at Stony Brook University used MRI to visualize the glymphatic system in rats that had been given a fluorescent tracer. The whole brain images allowed Benveniste and colleagues to identify two key influx nodes in the brain. Additionally, they could measure the rate at which the fluorescent tracer was removed by the glymphatic system. Currently, amyloid plaques and other molecules that accumulate in diseases such as Alzheimer's and Huntington's disease cannot be visualized in live patients. In a companion commentary, Warren Strittmatter of Duke University discusses how this new technology could be used to track the development or progression of diseases in which the clearance of specific proteins is impaired.

TITLE:
Brain-wide pathway for waste clearance captured by contrast enhanced MRI

AUTHOR CONTACT:
Helene Benveniste
Stony Brook University Medical Center, Stony Brook, NY, USA
Phone: 631-624-7018; Fax: 631-444-2907; E-mail: helene.benveniste@stonybrookmedicine.edu

View this article at: http://www.jci.org/articles/view/67677?key=e3d4b4a78599273ea579

ACCOMPANYING COMMENTARY

TITLE:
Bathing the brain

AUTHOR CONTACT:
Warren James Strittmatter
Duke University Medical Center, Durham, NC, USA
Phone: 919-684-0053; Fax: 919-681-7198; E-mail: warren@neuro.duke.edu

View this article at: http://www.jci.org/articles/view/68241?key=808d2caf308ec46730fb


ALSO IN THIS ISSUE

Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia

HDAC4 controls histone methylation in response to elevated cardiac load

Sprouty2, PTEN and PP2A interact to regulate prostate cancer progression

Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility | Back to top

TITLE:
Smap1 deficiency perturbs receptor trafficking and predisposes mice to myelodysplasia

AUTHOR CONTACT:
Masanobu Satake
Institute of Development, Aging and Cancer, Tohoku University, Sendai, UNK, JPN
Phone: (81)22-717-8477; E-mail: satake@idac.tohoku.ac.jp

View this article at: http://www.jci.org/articles/view/63711?key=81fb94bf3f59a4902e5b

TITLE:
HDAC4 controls histone methylation in response to elevated cardiac load

AUTHOR CONTACT:
Christoph Maack
Universittsklinikum des Saarlandes, Homburg, DEU
Phone: +49-6841-1623000; Fax: +49-6841-1623434; E-mail: christoph.maack@uks.eu

View this article at: http://www.jci.org/articles/view/61084?key=3b2f824d313bb1325d7a

TITLE:
Sprouty2, PTEN and PP2A interact to regulate prostate cancer progression

AUTHOR CONTACT:
Hing Leung
The Beatson Institute for Cancer Research, Glasgow, , GBR
Phone: 441413303658; E-mail: h.leung@beatson.gla.ac.uk

View this article at: http://www.jci.org/articles/view/63672?key=c51d70b1b0cef75eae44

TITLE:
Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility

AUTHOR CONTACT:
Tsang-Chih Kuo
Graduate Institute of Toxicology, College of Medicine, National Taiwan Univ, Taipei, TWN
Phone: 886-2-23123456#88649; E-mail: f95447013@ntu.edu.tw

View this article at: http://www.jci.org/articles/view/64044?key=48ac6b9d93d7fc1ccb38


'/>"/>
Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. Gene Therapy Shows Early Promise for Heart Failure
2. Early life stress may take early toll on heart function
3. Early Exposure to Gluten May Help Babies Avoid Celiac Risk: Study
4. Youth Smoking, Obesity May Lead to Early Death
5. Early education closes achievement gap, brings societal benefits
6. JCI early table of contents for Feb. 15, 2013
7. Those Childhood Piano Lessons Should Start Early
8. Deep Brain Stimulation May Help in Early Stages of Parkinsons
9. Researchers identify genetic root to early-onset prostate cancer
10. Early Dental Care Can Help Keep Kids Smiling for Years to Come
11. JCI early table of contents for Feb. 8, 2013
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson ... Recently, he has implemented orthobiologic procedures as a method for treating his patients. ... the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons ...
(Date:6/24/2016)... ... ... A recent article published June 14 on E Online details ... to state that individuals are now more comfortable seeking to undergo not only the ... and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians (BHP) notes ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
(Date:6/24/2016)... ... , ... People across the U.S. are sharpening their pencils and honing their ... in which patients and their families pay tribute to a genetic counselor by nominating ... of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... CLEMENTE, Calif. , June 24, 2016  American Respiratory Labs ... company, is now able to perform sophisticated lung assessments in patients, ... Technologies , Inc. Patients are no longer limited ... ndd,s EasyOne PRO ® , ARL patients like Jeanne R. of ... done in the comfort of her own home. ...
Breaking Medicine Technology: