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JCI early table of contents for Feb. 15, 2013
Date:2/15/2013

A smoking gun in lung cancer epigenetics

Recent studies have identified correlations between cigarette smoke-induced microRNA (miRNA) expression and different aspects of lung cancer; however, it is unclear how miRNA expression directly contributes to carcinogenesis. MiRNAs regulate the expression of target genes and can have a significant impact on when and how well different gene products are expressed. In this issue of the Journal of Clinical Investigation, David Schrump and colleagues at the National Cancer Institute in Bethesda, MD, measured miRNA expression in normal human lung cells exposed to cigarette smoke condensate (CSC) and lung cancer cells derived from smokers and non-smokers. They found that CSC exposure repressed the miRNA-487b. Loss of miRNA-487b increased the expression of five critical oncogenes and enhanced the proliferation, invasion, tumorigenicity, and metastatic capacity of lung cells. Loss of miRNA-487b and concomitant up-regulation of the five oncogenes was also observed in patient lung cancer specimens. These results reveal a direct mechanism by which cigarette smoke-induced miRNA alterations promote lung carcinogenesis.

TITLE:
Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis

AUTHOR CONTACT:
David Schrump
National Cancer Institute, Bethesda, MD, USA
Phone: 301-496-2128; E-mail: david_schrump@nih.gov

View this article at: http://www.jci.org/articles/view/61271?key=1f628155b6680108ff1a


Researchers identify a factor that may contribute to increased heart attack-related mortality in diabetics

Diabetic patients are more than twice as likely to die from a heart attack as non-diabetic patients, but the mechanisms that underlie increased heart attack-related mortal
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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