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JCI early table of contents for Feb. 1, 2013
Date:2/1/2013

the Journal of Clinical Investigation, Ziad Mallat and colleagues at Addenbrooke's Hospital in Cambridge, England, identified a protein, MFGE8, that blocks inflammasome activity. Using a mouse model of stroke, Mallat and colleagues determined that expression of MFGE8 inhibited the production of pro-inflammatory products and limited the area of injury after stroke. These results identify MFGE8 as an important regulator of inflammation that could potentially serve as a useful therapeutic target in inflammatory disease.

TITLE:
MFGE8 inhibits inflammasome-induced IL-1β production and limits post-ischemic cerebral injury

AUTHOR CONTACT:
Ziad Mallat
University of Cambridge, Cambridge, GBR
Phone: +44 (0)1223 746720; E-mail: zm255@medschl.cam.ac.uk

View this article at: http://www.jci.org/articles/view/65167?key=9c368b2173b91a4a0e01

ALSO IN THIS ISSUE

TITLE:
IQGAP1 suppresses TβRII-mediated myofibroblastic activation and metastatic growth in liver

AUTHOR CONTACT:
Ningling Kang
Mayo Clinic in Rochester, Rochester, MN, USA
Phone: 5075387552; E-mail: kang.ningling@mayo.edu

View this article at: http://www.jci.org/articles/view/64742?key=5c508faefc60a69bb7a1

TITLE:
Virus-induced hepatocellular carcinomas cause antigen-specific local tolerance

AUTHOR CONTACT:
Thomas Blankenstein
Max Delbrck Center for Molecular Medicine, Berlin, DEU
Phone: 49-30-9406-2816; Fax: 49-30-9406-2453; E-mail: tblanke@mdc-berlin.de

View this article at:

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1 2 3 4

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