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JCI early table of contents for April 8, 2013
Date:4/8/2013

rnal of Clinical Investigation, Alfred Nordheim and colleagues at Tuebingen University in Tuebingen, Germany, identified the DNA transcription factor SRF and its cofactors MRTF-A and MRTF-B as critical regulators of vascularization in the postnatal mouse eye. Loss of vascular Srf in adult mice led to the formation of microaneurysms and excess blood vessel formation similar to human retinal diseases such as retinal angiomatous proliferation and macular telangiectasia. These studies demonstrate that SRF plays an integral role in the development and homeostasis or the retinal vasculature and suggest that SRF could potentially serve as a therapeutic target in human retinal diseases.

TITLE:
Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae

AUTHOR CONTACT:
Alfred Nordheim
Tuebingen University, Tuebingen, DEU
Phone: 4970712978898; E-mail: alfred.nordheim@uni-tuebingen.de

View this article at: http://www.jci.org/articles/view/64201?key=4dc1a65206b8018e0e4b


ALSO IN THIS ISSUE

TITLE:
Loss of acinar cell Ikka triggers spontaneous pancreatitis in mice

AUTHOR CONTACT:
Michael Karin
University of California, San Diego, La Jolla, CA, USA
Phone: 858-534-1361; Fax: 858-534-8158; E-mail: karinoffice@ucsd.edu

View this article at: http://www.jci.org/articles/view/64498?key=8da89eb7ab14951f7606

TITLE:
Natural variation in Fc glycosylation of HIV-specific antibodies impacts anti-viral activity

AUTHOR CONTACT:
Galit Alter
Massachusetts General Hospital, Charlestown, MA, USA
Phone: 617-724-0546; Fax: 617-72
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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