Navigation Links
JCI early table of contents for April 8, 2013
Date:4/8/2013

Protecting against aging at the molecular level

High fidelity DNA replication during each cycle of cell division is required to maintain genomic stability and prevent chromosomal mutations and rearrangements that can cause disease and aging. Mutations in ATRX, a gene that encodes a protein that participates in DNA replication, are associated with X-linked mental retardation, various cancers, and developmental disorders, but the cellular functions of ATRX are still unclear. In this issue of the Journal of Clinical Investigation, researchers led by Nathalie Brub at the University of Western Ontario report on the effects of Atrx deficiency in mice. Using neural precursor cells (NPCs) from Atrx-deficient mice, Brub and colleagues found that loss of ATRX is associated with increased DNA damage. Additionally, mice lacking neural Atrx exhibited systemic endocrine dysfunction, shortened lifespans, and degenerative phenotypes similar to human premature aging disorders. These studies demonstrate that ATRX plays a critical role in maintaining the integrity of cellular DNA.

TITLE:
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced lifespan

AUTHOR CONTACT:
Nathalie G Brub
Children's Health Research Institute, The University of Western Ontario, London, ON, CAN
Phone: 519-685-8500 x 55066; Fax: 519-685-8616; E-mail: nberube@uwo.ca

View this article at: http://www.jci.org/articles/view/65634?key=d3e4230ee774cca17a25


Researchers identify transcription factors that regulate retinal vascularization

The retina is a highly vascularized tissue, but too much or too little vascularization can lead to visual impairment and diseases such as familial exudative vitreoretinopathy or macular degeneration. In this issue of the Journal of Clinical Investigation, Alfred Nordheim and colleagues at Tuebingen University in Tuebingen, Germany, identified the DNA transcription factor SRF and its cofactors MRTF-A and MRTF-B as critical regulators of vascularization in the postnatal mouse eye. Loss of vascular Srf in adult mice led to the formation of microaneurysms and excess blood vessel formation similar to human retinal diseases such as retinal angiomatous proliferation and macular telangiectasia. These studies demonstrate that SRF plays an integral role in the development and homeostasis or the retinal vasculature and suggest that SRF could potentially serve as a therapeutic target in human retinal diseases.

TITLE:
Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae

AUTHOR CONTACT:
Alfred Nordheim
Tuebingen University, Tuebingen, DEU
Phone: 4970712978898; E-mail: alfred.nordheim@uni-tuebingen.de

View this article at: http://www.jci.org/articles/view/64201?key=4dc1a65206b8018e0e4b


ALSO IN THIS ISSUE

TITLE:
Loss of acinar cell Ikka triggers spontaneous pancreatitis in mice

AUTHOR CONTACT:
Michael Karin
University of California, San Diego, La Jolla, CA, USA
Phone: 858-534-1361; Fax: 858-534-8158; E-mail: karinoffice@ucsd.edu

View this article at: http://www.jci.org/articles/view/64498?key=8da89eb7ab14951f7606

TITLE:
Natural variation in Fc glycosylation of HIV-specific antibodies impacts anti-viral activity

AUTHOR CONTACT:
Galit Alter
Massachusetts General Hospital, Charlestown, MA, USA
Phone: 617-724-0546; Fax: 617-726-5411; E-mail: galter@partners.org

View this article at: http://www.jci.org/articles/view/65708?key=259e1956bd16b3da2139

TITLE:
CCDC22 deficiency in humans blunts activation of pro-inflammatory NF-κB signaling

AUTHOR CONTACT:
Ezra Burstein
University of Texas Southwestern Medical Center, Dallas, TX, USA
Phone: 214-648-2008; Fax: 214-648-2022; E-mail: ezra.burstein@utsouthwestern.edu

View this article at: http://www.jci.org/articles/view/66466?key=e9513cca064259fdf788

TITLE:
HIF1α and HIF2α independently activate SRC to promote melanoma metastases

AUTHOR CONTACT:
William Kim
University of North Carolina, Chapel Hill, NC, USA
Phone: 919-966-4765; E-mail: wykim@med.unc.edu

View this article at: http://www.jci.org/articles/view/66715?key=f24859543559147acb78

TITLE:
Smoothened is a master regulator of adult liver repair

AUTHOR CONTACT:
Anna Mae Diehl
Duke University Medical Center, Durham, NC, USA
Phone: 919-684-4173; Fax: 919-684-4183; E-mail: diehl004@mc.duke.edu

View this article at: http://www.jci.org/articles/view/66904?key=05c91856cad4eb6a6fc7

TITLE:
Eosinophil pathogenicity mechanisms and therapeutics in neuromyelitis optica

AUTHOR CONTACT:
Alan Verkman
University of California, San Francisco, San Francisco, CA, USA
Phone: 415-476-8530; Fax: 415-665-3847; E-mail: Alan.Verkman@ucsf.edu

View this article at: http://www.jci.org/articles/view/67554?key=eb9bbcb11dc37e2fc635


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Related medicine news :

1. Causes of migraines nearly impossible to determine
2. Nearly 30 Percent of Americans Have High Blood Pressure: CDC
3. Cartilage Gives Early Warning of Arthritis, Study Finds
4. JCI early table of contents for April 1, 2013
5. Early COPD diagnosis possible with nuclear medicine
6. Blood Test Might Spot Pancreatic Cancer Early, Study Finds
7. New metabolite-based diagnostic test could help detect pancreatic cancer early
8. Genes and Early Wheezing Tied to Childhood Asthma Risk
9. Nearly 14 Million Cancer Survivors in U.S.: Report
10. Is Early Baldness in Blacks a Clue to Prostate Cancer?
11. Early-onset baldness in African-American men may be linked to prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... Elk Grove Village, IL (PRWEB) , ... January ... ... protection and personal audio products, will demonstrate their groundbreaking GunSport•PRO® and EB15•LE® electronic ... Expo and Convention Center in Las Vegas, Booth #2809. The SHOT Show is ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... Prairie’s award-winning Reflection® brand of custom seating systems has a well-earned reputation for ... with a platform for innovation and growth in the custom seating business, which ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... Aesthetic Surgery Journal , the official journal of The American Society for ... eyelid retraction surgery. The procedure is designed to correct drooping, retracted lower eyelids, ...
(Date:1/16/2017)... ... ... NexTec Group has been selected as a member of the Bob Scott’s VAR ... field of midmarket financial software. , Members of the VAR Stars were selected based ... on revenue and those firms chosen represent a wide range of size and many ...
(Date:1/15/2017)... ... January 15, 2017 , ... "On Tour is a music themed slideshow ... ease," said Christina Austin - CEO of Pixel Film Studios. , On Tour’s ... the style and animation of their slideshows. Place each slide on top of another ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... DUBLIN , Jan 16, 2017 Research ... Myeloma Drugs Market 2017-2021" report to their offering. ... Global multiple myeloma drugs ... 2017-2021. The report covers the present scenario and ... 2017-2021. To calculate the market size, the report considers the revenue ...
(Date:1/16/2017)... -- An aneurysm develops due to the weakening of blood vessel ... occur in any artery, it happens most often in the ... legs. Most aortic aneurysms occur in the section of the ... abdominal aortic aneurysms, sometimes in the chest referred as thoracic ... abdomen is about 2 cm but in the case of ...
(Date:1/16/2017)... YORK , Jan. 16, 2017  This ... peripherally inserted central catheters market for the period ... to offer updates and information related to market ... market. This comprehensive market study demonstrates the various ... environment and future status of the global peripherally ...
Breaking Medicine Technology: