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JCI early table of contents for April 1, 2013
Date:4/1/2013

depends predominantly on glucose as an energy source, it can also use alternative fuels, such as lactate, to satisfy its energy requirements. In this issue of the Journal of Clinical Investigation, Raimund Herzog and colleagues at Yale University used magnetic resonance spectroscopy (MRS) to measure the concentrations and enrichment of different energy substrates and their metabolites in a rat model of recurrent hypoglycemia. They found that recurrent hypoglycemia enhances neuronal uptake of lactate which allows the brain to retain normal neural activity during hypoglycemia. These observations suggest that lactate supports neuronal function and indicate that supplementation of alternative fuels could protect the brain during hypoglycemia.

TITLE:
Lactate preserves neuronal metabolism and function following antecedent recurrent hypoglycemia

AUTHOR CONTACT:
Raimund I. Herzog
Yale School of Medicine, New Haven, CT, USA
Phone: 203-737-4773; E-mail: raimund.herzog@yale.edu

View this article at: http://www.jci.org/articles/view/65105?key=b71f996b96b91c84d096


ALSO IN THIS ISSUE

TITLE:
MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation

AUTHOR CONTACT:
Stanley Nattel
Montreal Heart Institute, Montreal, PQ, CAN
Phone: (514) 376-3330 ext. 3990; Fax: (514) 376-1355; E-mail: stanley.nattel@icm-mhi.org

View this article at: http://www.jci.org/articles/view/62185?key=ef2561a4a7949ec7f659

TITLE:
Melanoma adapts to RAF/MEK inhibitors through FOXD3-mediated upregulation of ERBB3

AUTHOR CONTACT:
Andrew Aplin
Thomas Jefferson
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Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

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