Navigation Links
JAMA study shows what works in treating HIV-infected African children
Date:10/24/2007

BIRMINGHAM, Ala. Providing HIV combination antiretroviral drug therapy is key to saving the lives of African children infected with the disease.

Letting nurses and other trained health care workers deliver that therapy and monitor patients, especially when doctors are in short supply, is just as important to saving lives, according to a new study by the University of Alabama at Birmingham (UAB).

Data for the study was gathered by following the health of 4,975 children for three years at the Centre for Infectious Disease Research in Zambia (CIDRZ), a nonprofit clinical, research and training center run by UAB faculty in conjunction with the Zambian government. The results are published in the Journal of the American Medical Association.

On average, children enrolled in the study experienced a more than doubling of their CD4 cell counts after one year of antiretrovirals, from an average of 12.9 percent CD4 count to 27 percent CD4 count, the researchers said.

The CD4 count is a blood test for a certain type of white blood cell that allows health care providers to monitor the effect of human immunodeficiency virus (HIV) on the immune system. Low CD4 counts are a sign of a weakening immune system, which puts patients at increased risk for developing AIDS and other opportunistic infections.

We know from work in the U.S. and Europe that children do well on antiretroviral drugs. But we were surprised in this study at just how high their CD4 counts went, and how quickly they went up, said Jeffrey Stringer, M.D., director of CIDRZ and a professor in UABs Department of Obstetrics and Gynecology.

In addition to the improvements seen in the CD4 counts, the UAB study found HIV-infected children who received antiretrovirals went up noticeably in what is called the weight-for-age score. This measurement is calculated from standardized pediatric growth charts and is used to monitor the health of HIV-infected infants and children.

Many of the children enrolled in the study were already two points below their expected weight-for-age score, and those who were infected but did not get antiretrovirals worsened. But those who got the drugs went up in weight, and many of the youngest HIV patients in the study went up by an entire point in their weight-for-age score.

Also in the study, the pediatric care was provided by nurses and clinical officers, which are the equivalent to physician assistants in the United States. The decision by Zambian officials to allow HIV-infected children enrolled in the JAMA study to be treated by non-physicians allowed more lives to be saved, said Craig Wilson. M.D., director of UABs Sparkman Center for Global Health and a co-author on the study.

The prioritization by CIDRZ and the Zambian government of getting care to these children as well as the development of targeted protocols and training made all of this possible. It ensures the broadest access to treatment and benefit, Wilson said. He along with Celia Hutto, M.D. a professor of infectious diseases in the UAB Department of Pediatrics, traveled to Zambia repeatedly to help develop protocols and train health workers in pediatric HIV care.

The Zambian Ministry of Health, through CIDRZ and other international health agencies, provide antiretrovirals at primary care clinics in Lusaka, where HIV infection rates are high. Stringer said the drug-therapy project in children is being done in conjunction with a large-scale project to reduce mother-to-child HIV transmission through patient testing and education.


'/>"/>

Contact: Troy Goodman
tdgoodman@uab.edu
205-934-8938
University of Alabama at Birmingham
Source:Eurekalert

Related medicine news :

1. Rural Canadians travel far for specialists: study
2. A new study surpasses Gene Therapy Hurdle
3. Tomato Sauce reduces Cancer Risk- Study
4. A question on study of Adult Stem Cell
5. Study on obesity and heart failure
6. National Lung Study in the process
7. Marijuana gateway theory strengthened by study of twins
8. Old theory of adaptation confirmed by new study
9. Study casts doubt on keyboard ills
10. Gene study links endometriosis, infertility
11. Study reveals how stress can make you sick
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... February 24, 2017 , ... With ProGlass Prism users now ... . Users have total control over position, rotation, distortion, edge softness, edge blur, chromatic ... Cut Pro X. , With ProGlass Prism users are given the tools and ...
(Date:2/24/2017)... Abilene, Texas (PRWEB) , ... February 24, 2017 , ... ... article that focuses on Bible Prophecy concerning this present generation. Yisrayl makes an ... of this current generation. He explains that the Bible details the current times ...
(Date:2/24/2017)... (PRWEB) , ... February 24, 2017 , ... Indiana Fiber ... from the company later this year. Dyer started as the Chairman of the ... for the establishment of the corporation including the recruitment of investor/owners and development of ...
(Date:2/24/2017)... ... 24, 2017 , ... Rosica Communications, a national PR ... media relations, social media, content marketing and SEO, is now offering direct, social ... intuitive marketing automation platform. , Rosica will now offer the platform to its ...
(Date:2/24/2017)... ... February 24, 2017 , ... Castle Farms, the celebrated ... Giveaway, with the winning couple announced on Feb. 14, 2017, on Facebook. The ... local vendors: A Matter of Taste, Ryan Rousseau Enterprises, A Touch of Spring ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... , Feb. 23, 2017 Regulus ... the discovery and development of innovative medicines targeting microRNAs, ... year 2016 financial results on Thursday, March 2, 2017 ... a conference call and webcast on March 2, 2017 ... and full year 2016 financial results and provide a ...
(Date:2/23/2017)... The fast-growing cannabis market is expected to create ... According to the 2017 Legal Marijuana Outlook, published by New ... jobs by 2020, with an implied growth rate of more ... accelerating pace of cannabis legalization is considered as the main ... will further create more business ventures and boost the economy. ...
(Date:2/23/2017)... 2017 LG Innotek today announced that the company has ... its sterilization performance is 1.5 times higher than the competitor,s 45mW ... in the range of 200 -- 280nm, allowing it to be used ... their DNA. LG Innotek,s product emits UV in the range of ... Until now, ...
Breaking Medicine Technology: