Navigation Links
JAMA study reports on fatty liver disease in children and teens
Date:4/28/2011

INDIANAPOLIS The largest study of its type has found that neither vitamin E, which is an antioxidant, nor the diabetes drug metformin, successfully reduced liver enzymes in nonalcoholic fatty liver disease in children or teens, according to a paper published in the April 27, 2011 issue of Journal of the American Medical Association. The study also found that in patients with a severe type of fatty liver disease, a biopsy of the liver showed improvement in the injury pattern with vitamin E therapy.

Nonalcoholic fatty liver disease is the most common cause of chronic liver disease in children in the United States. The Indiana University School of Medicine and Riley Hospital for Children at Indiana University Health comprised one of the largest of the 10 sites nationwide that conducted the randomized, controlled trial of the disease between September 2005 and March 2010.

"Currently the only treatment for nonalcoholic fatty liver disease is diet and exercise counseling, but this is often not effective," said Jean P. Molleston, M.D., professor of clinical pediatrics at IU School of Medicine and director of pediatric gastroenterology, hepatology and nutrition at Riley at IU Health, who directed the Indiana site. "While we were disappointed that neither vitamin E nor metformin significantly reduced liver enzymes tested in blood draws from the children and teens in the study, we did note that for a subgroup of those in the study whose biopsies showed definite fatty liver hepatitis ("NASH") or many swollen liver cells ("ballooned cells"), there was improvement with vitamin E."

"Due to the risks of liver biopsy, we need to develop noninvasive markers, to be found perhaps in blood or even stool, for identification and monitoring of those who may benefit from vitamin E," she said. "We need to tackle the disease before it becomes full blown in adulthood and significantly damages the liver."

According to the Centers for Disease Control, obesity affects 17 percent of children and teens in the United States, which is three times the rate of the previous generation. Non-alcoholic fatty liver disease occurs in approximately one out of six obese children, often without symptoms. While not life threatening to children, the disease, in which fat accumulates in the liver causing it to swell, can lead to scarring of the liver, sometimes requiring transplantation in adulthood.

Nonalcoholic fatty liver disease is more prevalent in boys than girls. It is more common in Hispanics than Caucasians and is less common in African-Americans.


'/>"/>

Contact: Cindy Fox Aisen
caisen@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
JAMA study reports on fatty liver disease in children and teens
(Date:2/11/2016)... ... 11, 2016 , ... PharmMD CEO Robert Yeager ... focus on contract negotiations, corporate strategy and healthcare data law. Additional responsibilities will ... in data breaches for the Part D Star Rating improvement and Medication Therapy ...
(Date:2/11/2016)... ... February 11, 2016 , ... ... master charity program created to assist the people of their local community. The ... nonprofit organizations and community leaders. Their hope is to bring awareness to important ...
(Date:2/11/2016)... Long Island, NY (PRWEB) , ... February 11, ... ... (INS) has enhanced and updated its hallmark resource, Infusion Therapy Standards of Practice, ... global leader in vein illumination with an estimated 85% share of the market, ...
(Date:2/11/2016)... ... February 11, 2016 , ... Duterte Insurance Group, serving the ... a new charity campaign to raise funds for Ronald McDonald House Charities. On ... https://donate.rmhc.org/ . , Ronald McDonald House (RMH) is an internationally renowned nonprofit organization ...
(Date:2/11/2016)... ... 2016 , ... The annual list showcases the 20 Most Promising SharePoint Solution ... dedication and commitment to the SharePoint ecosystem. A panel of experts and members of ... to recognize and promote technology entrepreneurship. , The survey was made at the ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... Feb. 11, 2016 Potrero Medical, Inc., the developer ... announce the appointment of George M. Rapier, III , ... Antonio, TX , WellMed is one of the nation,s ... and HMO members in Texas and ... out of his own internal medicine practice, he has been ...
(Date:2/11/2016)... and PORTLAND, Ore. , Feb. 11, ... company, is pleased to announce the acquisition of SolutionsRx, ... and rural access hospitals. Along with providing traditional contract ... consulting services to assist clients in navigating the complex ... , CEO of Wellpartner. --> James R. ...
(Date:2/11/2016)... ROLLING MEADOWS , Ill. and INDIANAPOLIS ... major milestone for many young people, but for those ... demanding. Not only do these students juggle class schedules, ... challenges of living with type 1 diabetes. On top ... the first time. Diabetes Scholars Foundation ...
Breaking Medicine Technology: