Navigation Links
JAMA article contends earlier study overstated validity of findings on bisphenol A
Date:2/18/2009

In a letter to be published in this week's Journal of the American Medical Association (JAMA), Dr. S. Stanley Young, Assistant Director of Bioinformatics at the National Institute of Statistical Sciences, and Ming Yu, University of British Columbia, highlight the statistical limitations of a study claiming that bisphenol A is associated with cardiovascular diagnoses, diabetes and abnormal blood level liver enzyme levels. The earlier study, published in JAMA (September 16, 2008) by Dr. Ian A. Lang and colleagues, did not adequately address the potential for multiple testing to result in a false positive result.

Young and Yu note that the CDC National Health and Nutrition Examination Survey [2003-2004] that was used in Lang et al's study measured 275 environmental chemicals and a wide range of health outcomes.

Although the Lang et al study focused on one chemical and 16 health outcomes, Young and Yu note that it is important to focus on how many questions were at issue. They point out that with 32 possible health outcomes, including combinations, potentially associated with any of the 275 chemicals, along with multiple confounders and statistical models, there could be as many as approximately 9 million statistical models available to analyze the data. Given the number of questions at issue and possible modeling variations in the CDC design, Young and Yu conclude that the findings reported by the authors could well be the result of chance rather than representing real health concerns.


'/>"/>

Contact: Jamie Nunnelly
nunnelly@niss.org
919-685-9319
National Institute of Statistical Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. Nanoparticle smart bomb targets drug delivery to cancer cells
2. JAMA Article Provides Guidance to Physicians on End-of-Life Care
3. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
4. PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine
5. Team Designs Gold Nanoparticles to Deliver Multiple Drugs
6. Gold nanoparticles for controlled drug delivery
7. Fresh Thinking: Harvard Business Review Article Explores When and How Companies Must Reinvent Their Businesses
8. Nontoxic nanoparticle can deliver and track drugs
9. Nanoparticles trigger cell death?
10. Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community
11. Free Article Now Available: 'Rights Expanding for Plaintiffs with In Utero Injuries'
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... The Visiting Nurse Association (VNA) of Somerset Hills is proud to host ... items from across the nation, this holiday-themed event will raise funds and awareness for ... The boutique will be open Saturday, November 4 (10:00 a.m. – 5:00 p.m.) ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... ... will be giving viewers the lowdown on sciatica in a new episode of ... that focuses on current events and innovation and investigates each subject in-depth with ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... ... 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ), one of the ... new design of the shoulder pad. The shoulder pad provides optimal support and ... pain while using cold therapy. By utilizing ice and water that is circulated from ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Mich. , Oct. 2, 2017 Diplomat ... 8th Day Software and Consulting, LLC , and ... 8th Day Software, based in Tennessee ... LLC. 8th Day expands EnvoyHealth,s service offerings for health ... development. "In an ...
(Date:10/2/2017)... 2, 2017 Halo Labs announces the European launch of ... the HORIZON at MIBio 2017 in Cambridge, U.K ... particulate matter in biopharmaceutical samples with unprecedented speed and sensitivity while ... technique Backgrounded Membrane Imaging. ... HORIZON subvisible particle analysis system ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans Bioscience ... the use of wearable and home sensors for real-time ... Early Signal Foundation, a nonprofit organization focused on disruptive ... provide an affordable analytical system to record and integrate ... ...
Breaking Medicine Technology: