Navigation Links
JAMA article contends earlier study overstated validity of findings on bisphenol A
Date:2/18/2009

In a letter to be published in this week's Journal of the American Medical Association (JAMA), Dr. S. Stanley Young, Assistant Director of Bioinformatics at the National Institute of Statistical Sciences, and Ming Yu, University of British Columbia, highlight the statistical limitations of a study claiming that bisphenol A is associated with cardiovascular diagnoses, diabetes and abnormal blood level liver enzyme levels. The earlier study, published in JAMA (September 16, 2008) by Dr. Ian A. Lang and colleagues, did not adequately address the potential for multiple testing to result in a false positive result.

Young and Yu note that the CDC National Health and Nutrition Examination Survey [2003-2004] that was used in Lang et al's study measured 275 environmental chemicals and a wide range of health outcomes.

Although the Lang et al study focused on one chemical and 16 health outcomes, Young and Yu note that it is important to focus on how many questions were at issue. They point out that with 32 possible health outcomes, including combinations, potentially associated with any of the 275 chemicals, along with multiple confounders and statistical models, there could be as many as approximately 9 million statistical models available to analyze the data. Given the number of questions at issue and possible modeling variations in the CDC design, Young and Yu conclude that the findings reported by the authors could well be the result of chance rather than representing real health concerns.


'/>"/>

Contact: Jamie Nunnelly
nunnelly@niss.org
919-685-9319
National Institute of Statistical Sciences
Source:Eurekalert

Page: 1

Related medicine news :

1. Nanoparticle smart bomb targets drug delivery to cancer cells
2. JAMA Article Provides Guidance to Physicians on End-of-Life Care
3. LegalView Updates Avandia Information Portal With New Articles Detailing Potentially Dangerous Side Effects
4. PEGASYS(R) Proven Effective as Hepatitis C Treatment for Latino Patients, According to Article in The New England Journal of Medicine
5. Team Designs Gold Nanoparticles to Deliver Multiple Drugs
6. Gold nanoparticles for controlled drug delivery
7. Fresh Thinking: Harvard Business Review Article Explores When and How Companies Must Reinvent Their Businesses
8. Nontoxic nanoparticle can deliver and track drugs
9. Nanoparticles trigger cell death?
10. Nationally Recognized Diabetes Specialist Dr. Steven Edelman to Provide Educational Articles on Diabetes to MyCareTeam's Website Community
11. Free Article Now Available: 'Rights Expanding for Plaintiffs with In Utero Injuries'
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal ... Final Cut Pro X," said Christina Austin - CEO of Pixel Film Studios. ... Cut Pro X users can now reveal the media of their split screens ...
(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... ... to fertility once they have been diagnosed with endometriosis. These women need a ... they also require a comprehensive approach that can help for preservation of fertility ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June ... with. The article goes on to state that individuals are now more comfortable seeking ... common operations such as calf and cheek reduction. The Los Angeles area medical group, ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Jazz Pharmaceuticals plc (Nasdaq: JAZZ ... Antitrust Improvements Act of 1976, as amended ("HSR"), with ... ("Celator"; Nasdaq: CPXX ) expired effective June ... As previously announced on May 31, 2016, Jazz ... under which Jazz Pharmaceuticals has commenced a tender offer ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical ... the "Company"), which develops, markets and sells medical devices ... , signed a strategic cooperation agreement with Hongyuan ... "Hongyuan Supply Chain") on June 20, 2016, to develop ... the strategic cooperation agreement, Dehaier will leverage Hongyuan Supply ...
Breaking Medicine Technology: