Navigation Links
JAK inhibitors producing significant response in myelofibrosis patients
Date:12/6/2010

nimesh Pardanani, Ph.D. (http://mayoresearch.mayo.edu/staff/pardanani_a.cfm), the lead investigator on both studies. One of the two studies being presented at ASH is longer-term follow-up on the use of TG101348 in 59 patients with myelofibrosis who are being treated at Mayo Clinic, Stanford University Medical Center, MD Anderson Cancer Center, Dana-Farber Cancer Institute, University of Michigan and University of California, San Diego.

The study concludes that after 12 cycles of treatment, 95 percent of patients had some reduction in the size of their spleen. Within that group, 26 percent had a 100 percent reduction. The study also found that of the 48 patients who had a JAK2 mutation, 23 (48 percent) had a reduction in mutation burden. Patients who completed 12 cycles of therapy had the most reduction. Thirteen patients (72 percent) had a median 50 percent decrease. That response has lasted more than a year, says Dr. Pardanani.

The researchers also found that 56 percent of patients treated with 12 cycles of TG101348 achieved normal white blood cell counts.

"TG101348 represents the first proof of principle that a selective JAK2 inhibitor can shut down a signaling pathway and reduce the burden of neoplastic blood cells," Dr. Pardanani says. "It also offers significant clinical benefit in that it decreases spleen size, controls excess blood cell counts in more than half of patients, and improves symptoms such as fatigue and night sweats."

In the second study being presented at ASH, 32 of 36 enrolled patients had completed at least one cycle of CYT387 therapy in a phase I/II clinical trial. Within this group of patients, 41 percent achieved an improvement in anemia, as defined by the International Working Group criteria. And 97 percent had some degree of spleen-size reduction (at least a 50 percent reduction in 37 percent of those patients).

"CYT387 not only works to reduce spleen size and to help with other symptoms, but i
'/>"/>

Contact: Nicole Engler
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors
2. Pharmaceuticals: A market for producing lemons and serious harm
3. Study Finds That Insulin-Producing Beta Cells Can Be Reborn
4. UD team develops new method for producing proteins critical to medical research
5. Diabetes Research Made Significant Strides in Past Year
6. Citywide smoking ban contributes to significant decrease in maternal smoking, pre-term births
7. Chicago racial disparities in breast cancer mortality significantly higher than national average
8. Acid reflux, functional dyspepsia have significant impact on disordered sleep
9. Treatment of retinal conditions appears to have changed significantly in previous decade
10. Physical limitations take a significant toll in breast cancer survivors
11. Gum disease found to be significant public health concern
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... variant specifically associated with the risk of a ... cent of all breast cancer cases. , The ... called invasive lobular carcinoma, gives researchers important clues ... of breast cancer, which can be missed through ... the journal PloS Genetics , was co-led ...
(Date:4/17/2014)... of Experimental Biology and Medicine a ... and Paul Kenis in the Institute of Genomic ... of Illinois Urbana-Champaign describe their recent work on ... variety of cell functions including energy metabolism, signaling, ... in regulating normal cellular behavior, redox status has ...
(Date:4/17/2014)... Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, was recently ... issue of Nature Reviews Microbiology , one ... McCullers, a world-renowned infectious disease specialist, and chair ... of Tennessee Health Science Center, analyzed the epidemiology ... and 1968 pandemics, as well as more recent ...
(Date:4/17/2014)... 10 million older Americans suffer from depression, often brought ... new research a project that followed the lives ... found that Internet use among the elderly can ... percent. , "That,s a very strong effect," said Shelia ... studies and media who led the project. "And it ...
(Date:4/17/2014)... Medicine (BUSM) have discovered that the anti-seizure drug ... The findings, reported in the American Journal ... to more effective treatments for alcoholism. , Excessive ... causes of illness and death in the U.S. ... the productivity of workers and necessitating huge health ...
Breaking Medicine News(10 mins):Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 2Health News:First genetic link discovered to difficult-to-diagnose breast cancer sub-type 3Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:Internet use can help ward off depression among elderly 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2
... Feb. 4 Pulse Systems announced today ... the International,Organization for Standardization (ISO) quality systems ... "Achievement of these highly-regarded ... contract manufacturing services to the,medical device industry, ...
... (Nasdaq: KNSY ), a leading medical technology company ... of medical procedures, today announced the resignation of Mr. Jeffrey ... its Board of Directors.Mr. Smith became a director of Kensey ... Corporate Governance and Nominating Committee as well as a member ...
... Oxford, UK, 04 February 2009 The journal ... publication, has announced the winner of the 2008 David ... Persson and Jan van der Linden from the Karolinska ... decrease the risk of surgical site infection" was judged ...
... Md., February 4, 2009 With counterfeit and adulterated ... United States and worldwide, the U.S. Pharmacopeial (USP) Convention ... products that have been involved in episodes of adulteration ... these standards, for the blood thinner heparin and the ...
... EPA/DHA and 170% Daily Requirement of Vitamin EPARAMUS, N.J., Feb. ... today announced that it will launch Smart Balance(TM) Milk in ... and New England during the first quarter of 2009. ... in Florida and Georgia, tastes rich and creamy, is low ...
... in Four Americans Show Features Real People with Real Stories, ... and Denver Broncos, Quarterback Jay CutlerWESTPORT, Conn., Feb. 4 ... new 2009 television schedule for dLifeTV , ... with diabetes, airing every Sunday on CNBC at 7:00PM ET, ...
Cached Medicine News:Health News:Pulse Systems Receives Dual Certification Under ISO 13485:2003 and ISO 9001:2008 2Health News:Kensey Nash Announces Director Resignation 2Health News:USP announces new standards to protect patients from counterfeit and adulterated medicines 2Health News:Smart Balance to Bring Milk with More Taste and Less Fat to New York City and Albany Metro Areas and New England 2Health News:Smart Balance to Bring Milk with More Taste and Less Fat to New York City and Albany Metro Areas and New England 3Health News:dLifeTV Announces New Season Programming and Celebrity Guests; Only Nationally-Broadcast Program About Diabetes Celebrates 5th Year and 200th Show 2Health News:dLifeTV Announces New Season Programming and Celebrity Guests; Only Nationally-Broadcast Program About Diabetes Celebrates 5th Year and 200th Show 3
(Date:1/15/2014)... R.I. , Jan. 15, 2014 MultiCell Technologies, ... filed a U.S. provisional patent application concerning composition of ... to achieve targeted tumor cell death.  ... small noncoding double stranded RNA molecules (VSRNAs) which interfere ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... India Drug Forecast and Market Analysis to ... PharmaPoint: Atopic Dermatitis - India Drug ...
(Date:1/15/2014)... FRANKLIN, Ohio , Jan. 15, 2014  A novel wearable ... it easy and painless for patients to self-inject prescription drugs ... of disorders, including cancer, blood diseases, autoimmune deficiencies, and genetic ... expected to grow to $220B by 2018, according to analysts.   ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2
... products may protect against inflammation. Such were ... trial on the effects of processed tomatoes on ... men and women, presented by one of the ... 19, 2009 at the Experimental Biology meeting held ...
... Ability of PS-Targeting Antibodies to Reverse the Immune ... Microenvironment and Mobilizing Key Components of the Immune ... Stimulate Dendritic Cell Maturation, Inflammatory Cytokine and Chemokine ... and TUSTIN, Calif., April 21 Peregrine Pharmaceuticals, ...
Cached Medicine Technology:Processed Tomato Products May Protect Against Inflammation, According to a Study Presented at the Experimental Biology Meeting 2Processed Tomato Products May Protect Against Inflammation, According to a Study Presented at the Experimental Biology Meeting 3Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies 2Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies 3Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies 4Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies 5Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies 6Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies 7
1000L...
... 2000 Pipette is a synonym for pipetting ... robust design, and superior operating comfort. Its ... the measuring stroke and blow-out as well ... system ensures utmost accuracy and precision. Ejection ...
... new Finnpipette Focus from Thermo ... combine ergonomics with uncompromising performance. ... plate offers a custom fit ... new shorter tip cones allow ...
Inquire...
Medicine Products: