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JAK inhibitors producing significant response in myelofibrosis patients
Date:12/6/2010

ORLANDO, Fla. Two janus kinase (JAK) inhibitors are substantially improving treatment of myelofibrosis (http://www.mayoclinic.com/health/myelofibrosis/DS00886) in patients, say Mayo Clinic (http://www.mayoclinic.org/) researchers who are presenting results of several clinical trials at the 52nd annual meeting of the American Society of Hematology (http://www.hematology.org/ ) (ASH) Dec. 4𔃅 in Orlando.

VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Drs. Animesh Pardanani and Ayalew Tefferi describing the research, are available on the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/2010/12/03/myelofibrosis-study/). These materials also are subject to embargo, but may be accessed in advance by journalists for incorporation into stories. The password for this post is JAK387.

Their findings suggest that both drugs, CYT387 and TG101348, effectively reduce spleen size and alleviate constitutional symptoms, major symptoms of this disorder, but that each have unique benefits.

According to Ayalew Tefferi, M.D. (http://mayoresearch.mayo.edu/staff/tefferi_a.cfm), a Mayo Clinic hematologist and principal investigator for both clinical trials, results were both "surprising and pleasant" for CYT387, the first drug of its class to alleviate anemia in a substantial proportion of patients. TG101348 was also the first in its class to result in a measurable decline in JAK2 mutation burden and to substantially reduce high white blood cell and platelet counts, he says.

"These drugs represent smarter, targeted treatments that appear to make a substantial difference in treatment of this disorder," says A
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Contact: Nicole Engler
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

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