Navigation Links
JAK inhibitors producing significant response in myelofibrosis patients
Date:12/6/2010

ORLANDO, Fla. Two janus kinase (JAK) inhibitors are substantially improving treatment of myelofibrosis (http://www.mayoclinic.com/health/myelofibrosis/DS00886) in patients, say Mayo Clinic (http://www.mayoclinic.org/) researchers who are presenting results of several clinical trials at the 52nd annual meeting of the American Society of Hematology (http://www.hematology.org/ ) (ASH) Dec. 4𔃅 in Orlando.

VIDEO ALERT: Additional audio and video resources, including excerpts from an interview with Drs. Animesh Pardanani and Ayalew Tefferi describing the research, are available on the Mayo Clinic News Blog (http://newsblog.mayoclinic.org/2010/12/03/myelofibrosis-study/). These materials also are subject to embargo, but may be accessed in advance by journalists for incorporation into stories. The password for this post is JAK387.

Their findings suggest that both drugs, CYT387 and TG101348, effectively reduce spleen size and alleviate constitutional symptoms, major symptoms of this disorder, but that each have unique benefits.

According to Ayalew Tefferi, M.D. (http://mayoresearch.mayo.edu/staff/tefferi_a.cfm), a Mayo Clinic hematologist and principal investigator for both clinical trials, results were both "surprising and pleasant" for CYT387, the first drug of its class to alleviate anemia in a substantial proportion of patients. TG101348 was also the first in its class to result in a measurable decline in JAK2 mutation burden and to substantially reduce high white blood cell and platelet counts, he says.

"These drugs represent smarter, targeted treatments that appear to make a substantial difference in treatment of this disorder," says A
'/>"/>

Contact: Nicole Engler
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Afatinib benefits lung cancer patients whose cancer progressed after treatment with EGFR inhibitors
2. Pharmaceuticals: A market for producing lemons and serious harm
3. Study Finds That Insulin-Producing Beta Cells Can Be Reborn
4. UD team develops new method for producing proteins critical to medical research
5. Diabetes Research Made Significant Strides in Past Year
6. Citywide smoking ban contributes to significant decrease in maternal smoking, pre-term births
7. Chicago racial disparities in breast cancer mortality significantly higher than national average
8. Acid reflux, functional dyspepsia have significant impact on disordered sleep
9. Treatment of retinal conditions appears to have changed significantly in previous decade
10. Physical limitations take a significant toll in breast cancer survivors
11. Gum disease found to be significant public health concern
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... 2014 According to a new market ... Market (Neurosurgical Navigation Systems, ENT Navigation Systems and Orthopedic ... Trends and Forecast 2014 - 2020", the global surgical ... in 2013 and is expected to grow at a ... an estimated value of USD 295.5 million in 2020. ...
(Date:8/27/2014)... The National League for Nursing is pleased ... FAAN, became the inaugural director of the NLN/Chamberlain ... Science of Nursing Education , effective August 11. The ... Home for Transformative Excellence, established with the League’s historic ... , Under Dr. Dennis’s leadership, the NLN/Chamberlain Center will ...
(Date:8/27/2014)... Delta, a reliable supplier of high ... Cat D7R Dozers to its used bulldozer ... announced that all these items are offered with deep ... expand Delta’s market share in the coming September. ... special offer; he has much confidence in the discounted ...
(Date:8/27/2014)... FL (PRWEB) August 27, 2014 Millennium ... now a sponsor for Florida Mental Health Counselors Association ... benefits the new sponsorship is sure to provide. , ... professional needs of Florida’s licensed mental health counselors. The ... the American Counseling Association (ACA) and since then, it ...
(Date:8/27/2014)... NY (PRWEB) August 27, 2014 The ... Team ) is holding free events about “ Sexuality ... speaker Liz Treston. These straightforward and entertaining discussions are ... at Bussani Mobility (501 Concord Avenue, Mamaroneck, NY) and ... Central Avenue, Bethpage, NY). , The New York ...
Breaking Medicine News(10 mins):Health News:Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 2Health News:Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 3Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 2Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 3Health News:Betty Pierce Dennis to Lead NLN/Chamberlain College of Nursing Center for the Advancement of the Science of Nursing Education 4Health News:Reliable Supplier Delta Adds New Items To Its Used Bulldozer Collection 2Health News:Millennium Treatment Group Sponsors Florida Mental Health Counselors Association 2Health News:Bussani Mobility Sponsors New York Mobility Club Meetings September 9 & October 7 for People with Disabilities, Sexuality & Intimacy Discussed by Advocate Liz Treston 2
... Not Meeting Daily Physical,Activity Recommendations, INDIANAPOLIS, May ... homes are unlikely to be meeting physical activity,recommendations ... today,at the 55th Annual Meeting of the American ... family child care homes, as the second,largest child ...
... to Fitness, INDIANAPOLIS, May 30 If walking seems ... a stroll is,an easy way to lower pressure and for ... presented findings today at the,55th Annual Meeting of the American ... obese patients was designed to determine if,brisk walking alone was ...
... To Be Completed Within Automatic Form 10-K Extension ... ... May 30 KV Pharmaceutical Company,(NYSE: KVa/KVb), a fully integrated specialty ... prescription pharmaceuticals,announced today that it expects to complete and file its ...
... deployed in regions of the world where tuberculosis (TB) ... military now faces a growing medical problem. But it ... the problem lies with the growing number of pseudoepidemics, ... result of universal testing with a notoriously inaccurate tuberculin ...
... 30 The new University of,Detroit Mercy School of ... Saturday, May 31 from 9 a.m. to 1 p.m. ... offering free dental screenings for community,members, as well as ... held in celebration of the School of Dentistry,s 75th,Anniversary., ...
... MD, RDMS, of Christiana Care Health System, Wilmington, DE, ... with immediate access to patient medical records during a ... radiofrequency devices that electronically contain a persons medical records ... reduce medical charges, two often incompatible goals. , ...
Cached Medicine News:Health News:Preschoolers in Family Child Care Homes Need More Activity 2Health News:Brisk Walking Lowers Blood Pressure, Increases Fitness in Obese 2Health News:KV Pharmaceutical Company Updates Timing of Fiscal 2008 Securities and Exchange Commission Filings 2Health News:KV Pharmaceutical Company Updates Timing of Fiscal 2008 Securities and Exchange Commission Filings 3Health News:US soldiers in high-tuberculosis areas face new epidemic: false positives 2Health News:UDM School of Dentistry to Host Community Open House 2
(Date:8/27/2014)... By now, if you haven,t heard about the ... planet. The awareness campaign has brought this devastating disease to ... over $88.5 Million (and counting) for ALS. Every day, more ... starting to as well. One such company, Acorn ... who actually works with ALS sufferers and helps to provide ...
(Date:8/27/2014)... CHICAGO , Aug. 27, 2014  Hill-Rom Holdings, ... listen to a management presentation at the Morgan Stanley ... p.m. EDT. You are invited to listen ... http://ir.hill-rom.com/events.cfm or access it directly at ... be available one hour after conclusion of the live ...
(Date:8/27/2014)... 27, 2014 North American lighting leader OSRAM ... Award for the new OSRAM ITOS ® PHASER ® ... module for microscopy, endoscopy and surgical head lamps that delivers ... efficacy and lamp life. "We,re honored to be ... most innovative new technologies of the past year," said ...
Breaking Medicine Technology:Acorn Stairlifts Gives a Lift to the ALS Ice Bucket Challenge 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: