Navigation Links
It's about time: Disrupted internal clocks play role in disease
Date:7/1/2013

ctor leading to gut leakiness is not known, however. Our study suggests that disruption of circadian rhythms and sleep, which is part of life in industrial societies, can promote it and explain the susceptibility."

In the study, the Northwestern and Rush researchers used two independent approaches, studying both genetic and environmental animal models. The circadian rhythms of one group of mice were disrupted genetically: Each animal had a mutant CLOCK gene, which regulates circadian rhythms. The second group's circadian rhythms were disrupted environmentally: The animals' light-dark cycle was changed periodically, leading to a state similar to chronic jet lag.

Mice in both groups, prior to ingesting alcohol, showed an increase in gut leakiness.

Next, both groups of mice were fed alcohol. After only one week, animals in both groups showed a significant additional increase in gut leakiness, compared to control mice on an alcohol-free diet. At the end of the three-month study, mice in both groups were in the early stages of alcoholic liver disease.

"We have clearly shown that circadian rhythm disruption can trigger gut leakiness, which drives the more severe pathology in the liver," said Keith Summa, a co-first author of the study and an M.D./Ph.D. candidate working in Turek's lab.

"For humans, circadian rhythm disruption typically is environmental, not genetic, so individuals have some control over the behaviors that cause trouble, be it a poor sleep schedule, shift work or exposure to light at night," he said.

Sleep and circadian rhythms are an integral part of biology and should be part of the discussion between medical doctors and their patients, the researchers believe.

"We want to personalize medicine from a time perspective," Turek said. "Our bodies are organized temporally on a 24-hour basis, and this needs to be brought into the equation for understanding health and disease."


'/>"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Doctor-patient communication about dietary supplements could use a vitamin boost
2. Senior moment? Stereotypes about aging can hurt older adults memory, but theres an easy fix
3. What Nobody Tells You About Cancer
4. Brandith Irwin, MD, Answers New Blog Question on Her Website SkinTour.com About Preventing Eye Wrinkles at Ages 30 to 40
5. Corporate Whistle Blower Center Urges Physicians or Drug Maker Insiders to Call Them about Whistleblower Rewards-If They Have Proof a Drug Company Sold Bad Drugs
6. US Drug Watchdog Now Calls Their DePuy Pinnacle Hip Implant Blood Test Initiative Vital And They Urge Recipients To Call Them For Instructions About This Important Test
7. Arizona Blogger With Celiac Disease Determined to Write About Her Gluten-Free Journey
8. Boys Town Institute Offers Warnings About Fireworks and Hearing Loss
9. Genetics of cervical cancer raise concern about antiviral therapy in some cases
10. US Drug Watchdog Now Urges Recipients Of A DePuy Pinnacle All Metal Hip Implant To Call Them About A Vital Blood Test To See If Their Hip Implant Device Has Failed
11. Cancer Survivor Linda Christina Beauregard Writes New Tell-All Book About Her Alternative Treatment Method
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... treat children with uncomplicated acute appendicitis is a reasonable ... fewer missed school days, according to a pilot study. ... Hospital and published online April 12 in the ... the first prospective study on nonoperative management of acute ... , Researchers enrolled 77 patients age 7 to 17 ...
(Date:4/14/2014)... 2014, Perth, Australia. Drug discovery company Proteomics International ... of a companion diagnostic (CDx) test with the ... The research team authenticated the panel of biomarkers ... samples. Seven biomarkers were validated at high stringency ... The mass spectrometry data was then cross-validated using ...
(Date:4/14/2014)... 2014) When it comes to the cost and ... Patients get the best care when they are treated ... extensive experience in their current job, according to a ... and Columbia Business School. The study was published in ... Applied Economics . , The review of more ...
(Date:4/13/2014)... STANFORD, Calif. A low-cost empowerment program for ... and sexual harassment of these girls, who live ... and are frequently attacked, a large new study ... Stanford University School of Medicine, Lucile Packard Children,s ... No Worldwide, validated the program,s effectiveness in combating ...
(Date:4/11/2014)... the processes that control brain cell production could pave ... brain-related disorders. , Scientists have gained new understanding of ... how and when nerve and brain cells are formed ... and keeps it healthy. Their findings could help explain ... which is a fundamental characteristic of many diseases including ...
Breaking Medicine News(10 mins):Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 2Health News:Antibiotics alone are a successful treatment for uncomplicated acute appendicitis in kids 3Health News:Longer nurse tenure on hospital units leads to higher quality care 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 2Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 3Health News:Empowerment program greatly decreases incidence of rape, Stanford/Packard-led study finds 4
... WASHINGTON and NEWARK, N.J., March 4 ,Cathedral Healthcare ... States $5.3,million, plus interest, to settle allegations that ... announced today., The settlement resolves allegations that ... Medicare patients in order,to obtain enhanced reimbursement from ...
... Secretary Mike,Leavitt and the Secretary of Health of ... a Memorandum of Understanding (MOU) today,strengthening cross-border cooperation ... plan to work together on common health,problems. The ... in public,health; the document signed today updates a ...
... risk in post-menopausal women after they stopped taking combined ... that will be reported in the March 5 edition ... said Rowan T. Chlebowski, M.D., Ph.D., a Los Angeles ... to the study. , This latest study reinforces the ...
... DARA BioSciences(TM),(Nasdaq: DARA ) announced today the ... of Directors. Dr. Drutz was appointed to fill ... Compensation Committee as well as Corporate,Governance and Nominating ... Richard Franco, Sr., DARA,s Board Chairman, commented, "It ...
... (Nasdaq: ISTA ), today announced it will release ... the U.S. markets close. ISTA will,host a conference call, ... a commercial and pipeline update at 5:00 p.m. Eastern,Time ... call, U.S. and Canadian participants may,dial 866-831-6270; international participants ...
... to continued need for mammograms , , TUESDAY, March 4 (HealthDay ... a woman stops taking combination hormone replacement therapy, a new ... 5 issue of the Journal of the American Medical ... Health Initiative (WHI). That trial was halted abruptly in 2002, ...
Cached Medicine News:Health News:Cathedral Healthcare System to Pay U.S. $5.3 Million to Resolve Allegations Involving Inflated Charges to Obtain Higher Medicare Reimbursement 2Health News:United States and Mexico Renew Agreement on Cooperation in Health 2Health News:LA BioMed researcher says 'unexpected' increase in cancer risk found 2Health News:DARA BioSciences, Inc. Announces Appointment of Dr. David J. Drutz to Board 2Health News:Raised Breast Cancer Risk Persists After Combo HRT Stopped 2Health News:Raised Breast Cancer Risk Persists After Combo HRT Stopped 3
(Date:1/15/2014)... , Jan. 15, 2014  Research and Markets ... the "Dental Consumables Market - Global Industry ... - 2018" report to their offering. ... ) Dental consumables are products which are ... impairments, for tooth restoration and in treatment of ...
(Date:1/15/2014)... , Jan. 15, 2014  Novation, the leading ... company, awarded several new IT value-added reseller (VAR) ... hospital organizations with IT goods and services at ... agreements, as well as value-added services such as ... New Novation agreements were awarded to ...
(Date:1/15/2014)... DUBLIN , January 15, 2014 ... that it has waived the Office of Fair Trading (OFT) ... the outstanding shares of ViroPharma Incorporated (NASDAQ: VPHM).   ... no longer conditional on OFT approval, and Shire expects to ... currently scheduled expiration time, subject to the satisfaction of all ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3
... Calif., Oct. 27, 2011 Cardica, Inc. (Nasdaq: ... quarter ended September 30, 2011. Cardica,s management will host a ... the financial results and provide an update on the company,s ... leadership team of Dr. Swanstrom, a world-renowned key opinion leader ...
... eResearchTechnology, Inc. (ERT), (Nasdaq: ERT ... customizable medical devices to biopharmaceutical and healthcare organizations ... respiratory efficacy services in drug development, announced today ... 2011.  Unless otherwise noted, all comparative numbers refer ...
Cached Medicine Technology:Cardica Announces Fiscal 2012 First Quarter Financial Results 2Cardica Announces Fiscal 2012 First Quarter Financial Results 3Cardica Announces Fiscal 2012 First Quarter Financial Results 4Cardica Announces Fiscal 2012 First Quarter Financial Results 5Cardica Announces Fiscal 2012 First Quarter Financial Results 6ERT Reports Third Quarter 2011 Operating Results 2ERT Reports Third Quarter 2011 Operating Results 3ERT Reports Third Quarter 2011 Operating Results 4ERT Reports Third Quarter 2011 Operating Results 5ERT Reports Third Quarter 2011 Operating Results 6ERT Reports Third Quarter 2011 Operating Results 7ERT Reports Third Quarter 2011 Operating Results 8ERT Reports Third Quarter 2011 Operating Results 9ERT Reports Third Quarter 2011 Operating Results 10ERT Reports Third Quarter 2011 Operating Results 11ERT Reports Third Quarter 2011 Operating Results 12ERT Reports Third Quarter 2011 Operating Results 13
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: