Navigation Links
Itchy wool sweaters explained
Date:1/2/2013

ters around a group of nerve cells known to respond electrically to painful stimuli such as molecules of capsaicin, the fiery ingredient in chili peppers. A small subset of these nerve cells also responds electrically to itchy stimuli because they have on their surfaces receptors for molecules like histamine. One of these itchy receptors, called MrgA3, binds the anti-malaria drug chloroquine, causing serious itchiness in many patients.

Sensory nerve scientists have not known whether the nerves with itchy receptors and pain receptors were actually sending both types of messages to the brain, or just itch messages. What the current study found is that, in nerves with the itchy receptor MrgA3, electrical signals sent in response to both painful and itchy stimuli are interpreted by the brain as itch.

To reach this conclusion, the researchers first used a genetic trick to label the MrgA3 cells in mice with a glowing protein that allowed them to see the cells under the microscope. Aided by the glow, they were able to plug in those tiny electricity monitors and watch nerve cell responses to different stimuli. The cells transmitted electrical signals when the mice were exposed to itch-inducing chloroquine and histamine, as well as pain-inducing capsaicin and heat. Based on this result, the researchers tentatively concluded that the cells could send both pain and itch signals.

In the next experiment, the researchers monitored the behavioral responses of mice to the different stimuli. As expected, when the tails of normal mice were placed in hot water, they quickly pulled them out; when normal mice were given a bit of chloroquine or histamine, they scratched vigorously with their hind legs.

Then, to examine the role of MrgA3 cells in pain and itch, the scientists selectively killed MrgA3 nerve cells in adult mice and retested their responses. Presumably, the researchers noted, because MrgA3 cells are only a small fraction of all pain-sens
'/>"/>

Contact: Catherine Kolf
ckolf@jhmi.edu
443-287-2251
Johns Hopkins Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Fast-acting enzymes with 2 fingers: Protein structurally and dynamically explained
2. Psychologist Steve Wilson: Post-Holiday Let-Down May be Worse Than the Holiday Blues as Explained in New Handbook
3. Queens research gives fresh hope to couples with unexplained infertility
4. Rise in Pregnancy-Associated Cancers Not Fully Explained by Older Age
5. US Drug Watchdog Now Offers to Help All Woman Who Used Fosamax For Osteoporosis and Then Had an Unexplained a Femur Break Get to the Best Attorneys
6. Wake Forest Baptist research provides clue to unexplained excited delirium deaths
7. The REMARK checklist explained: How to use guidelines on reporting tumor marker prognostic studies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Itchy wool sweaters explained
(Date:9/17/2014)... 17, 2014 People who struggle to distinguish ... to http://www.perwickstrom.com and get the answer by reading ... point out, is that a business plan and a business ... together, commented Per Wickstrom. “The way I view it is ... business strategy which is part two.” , According to ...
(Date:9/17/2014)... 2014 (HealthDay News) -- Social networking sites can help ... For people who are obese, sites like Twitter and ... support from doctors as well as peers, researchers found. ... methods is that it offers the potential to be ... when compared to traditional approaches," the study,s lead author, ...
(Date:9/17/2014)... Bioluminescence, nanoparticles, gene manipulation these sound like ... in fact, they are components of an exciting ... In preclinical animal models of metastatic prostate cancer, ... VCU Institute of Molecular Medicine and Johns Hopkins ... molecular imaging approach that could revolutionize doctors, ability ...
(Date:9/17/2014)... (PRWEB) September 17, 2014 North Central ... recently granted several awards for their top-notch services. The ... experience, orthopedic care and GYN surgery. , Hospital-wide, North ... Excellence Award™. They have received this award for two ... the top 5 percent in the nation for Patient ...
(Date:9/17/2014)... 2014 Catalent Pharma Solutions, the ... development solutions for drugs, biologics and consumer health ... integrated service and technology offer based on the ... the company’s 450,000 sq. ft. Kansas City, MO ... integrate optimal formulation, development, analytical expertise, scale up ...
Breaking Medicine News(10 mins):Health News:Per Wickstrom’s Latest Blog Explores the Difference Between a Business Plan and a Business Strategy 2Health News:Social Networking Sites Can Help Obese Lose Weight: Study 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 2Health News:New non-invasive technique could revolutionize the imaging of metastatic cancer 3Health News:North Central Surgical Center Receives Several Accolades 2Health News:New OptiPact™ Technology Introduced by Catalent 2
... ... virtual reality device, the GaitAid, can help stroke patients learn to walk better. , ... Haifa, Israel (PRWEB) February 22, 2010 -- There are ... one of the leading causes of adult disability in the U.S. and Europe., , , , ...
... new survey has found that African-Americans are more likely ... lung cancer, as well as being more reluctant to ... according to researchers from Dana-Farber Cancer Institute and their ... the puzzling racial disparities in lung cancer treatment outcomes ...
... outlets for buying booze increases, so does neighborhood violence, ... The more bars, restaurants and other alcohol sales sites ... say researchers who studied crime statistics and alcohol licensing ... found an association between high assault rates and stores ...
... three million children have been born as a result of ... tube baby" in 1978. While the majority of these ... at greater risk of certain kinds of birth defects and ... and type 2 diabetes later in life. Carmen Sapienza, ...
... types of minimally invasive surgery to repair kidney blockages ... found that robot-assisted surgery was faster and resulted in ... in the Canadian Journal of Urology , Ashok ... Baptist Medical Center, compared laparoscopic and robot-assisted surgery for ...
... 20. "Nanotechnology could aid the future of development of the ... the academy of sciences for the developing world, and president ... at a panel session, "Re-emergence of Science, Technology and Education ... AAAS,s annual meeting in San Diego. "The Arab ...
Cached Medicine News:Health News:New Successful Treatment Improves Walking Post Stroke 2Health News:African-Americans' attitudes about lung cancer may hinder prevention 2Health News:More Bars Equals More Assaults, Study Finds 2Health News:Comparison shows robot-assisted option offers advantages for kidney surgery 2Health News:Nanotechnology could help Arab region 2
(Date:9/17/2014)... BRIC Gynecological Devices Market Outlook to ... new report, "BRIC Gynecological Devices Market Outlook to ... Gynecological Devices market. The report provides value, in ... average prices (in US dollars) within market segments ... and Mechanical Sterilization Devices (Tubal Clips and Rings)), ...
(Date:9/17/2014)... Sept. 17, 2014 The ambulance ... last decade due to the recession, an ... technological advancements. This BCC Research report analyzes ... of the ambulance and emergency medical services ... and hemorrhage control devices, equipment used for ...
(Date:9/17/2014)... YORK , Sept. 17, 2014 Pomerantz ... PDL BioPharma, Inc. ("PDL BioPharma" or the "Company") (NASDAQ: ... S. Willoughby at rswilloughby@pomlaw.com or 888-476-6529, ... BioPharma and certain of its officers and/or directors have ... Act of 1934.  On September 17, ...
Breaking Medicine Technology:BRIC Gynecological Devices Market Outlook to 2020 2BRIC Gynecological Devices Market Outlook to 2020 3Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of PDL BioPharma, Inc. - PDLI 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: