Navigation Links
Itching Not a Less Intense Form of Pain
Date:11/18/2008

Each are regulated by different molecular mechanisms, scientists show

TUESDAY, Nov. 18 (HealthDay News) -- Pain and itching are regulated by different molecular mechanisms, according to a Washington University study that challenges the long-held belief that itching is a less intense version of the body's response to pain.

This finding could prove important in improving treatment of chronic itching and pain.

Zhou-Feng Chen, of Washington University's Pain Center, in St. Louis, and colleagues found that pain signals are not affected in mice bred without an itch gene called gastrin-releasing peptide receptor (GRPR) or when the gene's actions are blocked. When the mice without the GRPR gene were exposed to itchy stimuli, they scratched less than normal mice.

GRPR, previously identified by the same team of researchers, makes a receptor found in a small number of nerve cells in a region of the spinal cord that transmits itch and pain signals, as well as temperature sensation, from the skin to the brain.

"There are two major types of itching," explained Chen, an associate professor of anesthesiology, psychiatry and developmental biology. Histamine-dependent itching is caused by bug bites or allergic reactions and can be treated with antihistamine drugs. Chronic, severe itching often occurs as a side effect of spinal injections of opioid drugs, such as morphine, given to chronic pain patients. This type of itching can't be relieved by antihistamines.

"Most scientists believed that the itching could not be separated from the drug's pain-killing effects," Chen said. But he and his team thought GRPR may be responsible for the itching but involved in the pain response.

"If we inject a GRPR inhibitor and morphine into the mouse spinal cord, the drug still has its normal analgesic effect, but the mice don't scratch. This is very interesting, because it demonstrates that analgesia and itching can be
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Walgreens Pays $35 Million, Settles Pharmacist-Whistleblower Qui Tam Drug Switching Allegations
2. Attorney General Corbett Announces $36.7 Million Multi-State Settlement With CVS/Caremark in National Dosage-Switching Investigation
3. CVS, Americas Largest Pharmacy Chain, Pays Nearly $37 Million to Settle Federal and State Generic Drug Switching Charges
4. Playing Catch in Winter Could Save Kids Pitching Arms
5. How pitching changes little leaguers shoulders
6. Switching to MA Coverage Unlikely for Current Beneficiaries With MediGap or Medicare Only
7. Ultra-fast, ultra-intense laser has clean-cut advantage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Itching Not a Less Intense Form of Pain
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
(Date:4/17/2014)... NY, April 17, 2014U.S. military personnel who served ... impact" concussive traumatic brain injury (TBI) were compared ... for other medical reasons. Differences in measures of ... 6-12 months after injury are reported in an ... peer-reviewed journal from Mary Ann Liebert, Inc., publishers. ...
(Date:4/17/2014)... million older Americans suffer from depression, often brought on ... research a project that followed the lives of ... found that Internet use among the elderly can reduce ... , "That,s a very strong effect," said Shelia Cotten, ... and media who led the project. "And it all ...
(Date:4/17/2014)... one in five infants in the United States annually ... several months after birth. Research into probiotic use for ... April 1, 2014 issue of the British Medical ... "Probiotics and Infant Colic," concluding that the use of ... did not reduce crying or fussing in infants ...
(Date:4/17/2014)... University School of Medicine (BUSM) have discovered that ... an experimental model. The findings, reported in the ... , may lead to more effective treatments for ... of the leading causes of illness and death ... impact by limiting the productivity of workers and ...
Breaking Medicine News(10 mins):Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2Health News:Internet use can help ward off depression among elderly 2Health News:New study says probiotic use for infant colic is not effective in reducing symptoms 2Health News:BUSM researchers find anti-seizure drug may reduce alcohol consumption 2
... ... enter the promotional code 2009CLEVE to get their $54 marrow cheek-swab kit at no cost. ... (Vocus) June 15, 2009 -- Two-year-old ... a bone marrow transplant, but so far her family has been unable to find one. Thanks ...
... NATICK, Mass., June 15 Boston Scientific Corporation (NYSE: ... nine studies involving the Company,s Urology/Gynecology products will be ... Urogynecological Association (IUGA). Presentations will feature Boston Scientific,s ... to treat pelvic floor prolapse and stress urinary incontinence ...
... pharmacies to design their workflow to be more efficient ... June 15 ASHP 2009 Summer Meeting and ... ) a leading provider of system solutions to acute ... (TM) 6.0 central pharmacy automation software solution. With ...
... FRANCISCO, June 15 Early results from the second series ... Pseudomonas aeruginousa and a 4.4 log reduction (99.994%) in Methicillin ... major concern to medical treatment facilities world wide with the ... "silent epidemic". The CDC reported (JAMA 2007) that MRSA alone ...
... DELRAY BEACH, Fla., June 15 Anyone considering hair ... procedure. , , Just the fact that it is ... Dangerous?" "This is one of the most common questions that ... Shiell, Founder of The Oro Organization, LLC. Shiell explains, "People ...
... NORTH LIBERTY, Iowa, June 15 Bio-Research Products announced today ... President and Chief Technology Officer of Bio-Research, reports that this ... DAO derived from pig kidney tissue. The enzyme is available ... , , Diamine Oxidase is useful for test assays ...
Cached Medicine News:Health News:Cleveland Residents Lining up to Help Save a Life with Free Donor Kits 2Health News:Boston Scientific's Urology/Gynecology Products Featured in Studies at International Urogynecological Association Annual Meeting 2Health News:Boston Scientific's Urology/Gynecology Products Featured in Studies at International Urogynecological Association Annual Meeting 3Health News:Boston Scientific's Urology/Gynecology Products Featured in Studies at International Urogynecological Association Annual Meeting 4Health News:Boston Scientific's Urology/Gynecology Products Featured in Studies at International Urogynecological Association Annual Meeting 5Health News:Boston Scientific's Urology/Gynecology Products Featured in Studies at International Urogynecological Association Annual Meeting 6Health News:Omnicell Boosts Pharmacy Efficiency with Enhanced WorkflowRx(TM) Central Pharmacy Automation Software 2Health News:Omnicell Boosts Pharmacy Efficiency with Enhanced WorkflowRx(TM) Central Pharmacy Automation Software 3Health News:Medizone Announces That Its AsepticSure(TM) Development Program is Reaching Objectives on Two Fronts 2Health News:USHairReplacement.com Provides Wealth of Knowledge to Common Hair Replacement Questions 2
(Date:1/15/2014)... AARP Foundation today announced it has established a ... severe cold weather that has gripped much of the nation. ... need; so to support these emergency relief efforts AARP and ... could mean up to $500,000 in aid. The matching program ...
(Date:1/15/2014)... Shire plc (LSE: SHP, NASDAQ: SHPG ) announces that ... to the announced tender offer for all of the outstanding shares ... of the waiver, the transaction is no longer conditional on OFT ... 24, 2014 following the currently scheduled expiration time, subject to the ...
(Date:1/15/2014)... 2014  In an unprecedented effort to curb the spread of "superbugs" ... transport vehicles, an advanced and portable UV germicidal lamp manufactured by ... time. In order to prevent EMS paramedics and ... West Palm Beach Fire Rescue is the first ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2
... Oct. 27 Pharmos Corporation (Pink Sheets: PARS ... nine-month period ended September 30, 2010. These results are included ... been filed with the SEC. During the quarter ... potential partners for Dextofisopam, its drug for irritable bowel syndrome ...
... N.J., Oct. 27 Systech International, innovator of ... Pac Automation, a leading supplier of end-of-line packaging ... integrated solution for global serialization requirements at Pack ... attendees have the opportunity to examine first hand ...
Cached Medicine Technology:Pharmos Corporation Reports 2010 Third Quarter Results 2Pharmos Corporation Reports 2010 Third Quarter Results 3Pharmos Corporation Reports 2010 Third Quarter Results 4Systech and Pester Pac Automation Exhibit Integrated Serialization Solution at Pack Expo 2010 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: