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Iso-osmolar X-ray dye falters in PCI study
Date:4/1/2008

CHICAGO, Ill. (April 1, 2008) - A new study has found that an x-ray dye intended to reduce stress on the kidneys did not prevent renal injury during percutaneous coronary intervention (PCI) in patients who already had compromised kidney function. In addition, it made no difference in the need for dialysis or in the length of hospital stay, according to the Contrast Media and Nephrotoxicity Following Coronary Revascularization by Angioplasty (CONTRAST) study.

The CONTRAST study is being reported today in a Late-Breaking Clinical Trials session at the SCAI Annual Scientific Sessions in Partnership with ACC i2 Summit (SCAI-ACCi2) in Chicago. SCAI-ACCi2 is a scientific meeting for practicing cardiovascular interventionalists sponsored by the Society for Cardiovascular Angiography and Interventions (SCAI) in partnership with the American College of Cardiology (ACC).

Some earlier studies have shown that iodixanol (Visipaque) reduces the risk of kidney damage when moderate doses of x-ray dye, or contrast medium, are used, mainly during diagnostic angiography. This is the first randomized trial to look exclusively at PCI, which involves far higher doses of contrast medium.

Heart disease is a serious health problem for patients with chronic renal failureand places them in a special bind. Depending on the severity of kidney dysfunction, the risk of suffering a heart attack or another type of cardiovascular event is estimated to be as much as four-fold higher than in patients without chronic renal failure.

"Patients with chronic renal insufficiency have a high need of coronary procedures; however, these procedures involve the use of contrast medium, which may lead to contrast-induced nephropathy, or further kidney damage," said Rainer Wessely, MD, PhD, an associate professor of medicine at Deutsches Herzzentrum, Technische Universitaet, Munich, Germany. "In addition, since chronic renal failure is associated with a higher incidence of
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Contact: Kathy Boyd David
pr@scai.org
717-422-1181
Weber Shandwick Worldwide
Source:Eurekalert

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