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Isis and Excaliard Collaborate to Develop Antisense Drugs for Local Treatment of Fibrotic Diseases
Date:11/27/2007

tics," stated Nicholas Dean, Ph.D., co-founder and CSO of Excaliard. Dr. Dean was formerly Vice President of Oncology and Functional Genomics at Isis. "Fibrosis represents a significant and expanding area of unmet medical need, and we believe that antisense offers unique advantages in this area for developing a completely new class of anti-fibrotic agents. Excaliard plans to exploit this exciting opportunity by rapidly moving multiple antisense drugs into clinical development."

"The broad applicability of our antisense technology enables us to build a substantial and diverse pipeline of antisense drugs. In order to maximize the value of this technology, a key component of our business strategy is to enter into promising partnerships that provide tremendous growth opportunities for antisense drugs in diseases that are outside of our main therapeutic areas, cardiovascular and metabolic diseases," said B. Lynne Parshall, Executive Vice President and CFO of Isis. "Excaliard will benefit from access to our technology and intellectual property and join a growing list of partners who have focused teams dedicated to advancing antisense drugs and who enable us to continue to expand the breadth of our antisense drug pipeline."

ABOUT EXCALIARD PHARMACEUTICALS, INC.

Excaliard is a newly formed, venture capital-funded biotechnology company focused on the development and commercialization of antisense drugs for the local treatment of scarring and other fibrotic diseases.

ABOUT RIVERVEST VENTURE PARTNERS

RiverVest Venture Partners is a venture capital firm investing in promising life sciences companies nationwide. RiverVest applies both its deep operating experience and the team's diverse range of expertise to create and grow successful enterprises that address unmet medical needs in major markets. RiverVest's extensive national network and privileged access to opportunities throughout the Midwest enable the firm to build a diverse portfolio of i
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SOURCE Isis Pharmaceuticals, Inc.
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