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Isis Scientist Awarded 2009 Ebert Prize
Date:4/6/2009

e have completed a multiple-dose Phase 1 study that provided further evidence that antisense drugs are active and well-tolerated when administered orally."

The Ebert Prize was established in 1873 by the APhA and is the oldest pharmacy award in the United States awarded annually to researchers who have reported significant results for original investigation published in the Journal of Pharmaceutical Sciences.

(1) Lloyd Tillman, Richard S. Geary, Gregory E. Hardee. Oral Delivery of Antisense Oligonucleotides in Man. Journal of Pharmaceutical Sciences. 2008; 97 (1): 225-36.

ABOUT ISIS PHARMACEUTICALS, INC.

Isis is exploiting its expertise in RNA to discover and develop novel drugs for its product pipeline and for its partners. The Company has successfully commercialized the world's first antisense drug and has 19 drugs in development. Isis' drug development programs are focused on treating cardiovascular and metabolic diseases. Isis' partners are developing antisense drugs invented by Isis to treat a wide variety of diseases. Isis and Alnylam Pharmaceuticals are joint owners of Regulus Therapeutics Inc., a company focused on the discovery, development and commercialization of microRNA therapeutics. Isis also has made significant innovations beyond human therapeutics resulting in products that other companies, including Abbott, are commercializing. As an innovator in RNA-based drug discovery and development, Isis is the owner or exclusive licensee of over 1,600 issued patents worldwide. Additional information about Isis is available at www.isispharm.com.

This press release includes forward-looking statements regarding Isis' discovery and development of antisense drugs and the potential for Isis' development of antisense drugs that can be administered orally. Any statement describing Isis' goals, expectations, financ
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SOURCE Isis Pharmaceuticals, Inc.
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