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Isis Reports That ISIS 301012 is Well Tolerated in Patients Treated for Five Or More Months
Date:10/5/2007

- Twelve of Sixteen FH Patients in an Ongoing Open-Label Extension Study Have Been Dosed With ISIS 301012 for Approximately Five Months or More, and

Four Have Been Dosed for More Than Six Months - Isis Will Host a Conference Call on Monday, October 8, at 8:00 a.m. E.T.

at http://www.isispharm.com

CARLSBAD, Calif., Oct. 5 /PRNewswire-FirstCall/ -- Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced the first safety results from its ongoing Phase 2 open-label extension (OLE) study of ISIS 301012 in patients with familial hypercholesterolemia (FH) on stable maximally tolerated lipid-lowering therapies. In addition, yesterday Isis announced results from a placebo-controlled Phase 2 study of ISIS 301012 in patients with heterozygous FH that were presented in a poster session today at the Drugs Affecting Lipid Metabolism (DALM) XVI International Symposium in New York City. Collectively, these results will be presented by Dr. John J.P. Kastelein in an oral session at DALM on Saturday at 3:45 p.m. E.T., and Isis will host a conference call Monday morning at 8:00 a.m. E.T. to discuss the results.

The ongoing Phase 2 OLE study includes 16 FH patients who had completed one of Isis' initial Phase 2 studies in FH patients and who subsequently enrolled in this open-label extension study. ISIS 301012 continues to be well tolerated by these patients with extended exposures and in the presence of continued maximally tolerated lipid-lowering therapies. As of September 17, four patients had received more than six months of weekly doses of ISIS 301012 over the course of both initial and OLE studies, and 12 of the 16 patients ha
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SOURCE Isis Pharmaceuticals, Inc.
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