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Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008
Date:2/25/2009

ging study in heterozygous FH subjects and long-term dosing data in FH patients exposed to mipomersen from three to 23 months.
  • Publishing preclinical data showing that lowering of apoB-100 resulted in significant reduction of atherosclerotic plaques in murine models of atherosclerosis.
  • In addition, Isis and its partners showed encouraging clinical results in a broad range of diseases including,

    • Encouraging Phase 2 data of OGX-011 in prostate cancer patients showing survival advantage, durable reductions in pain, and declines in PSA.
    • Positive Phase 2 results showing that ATL/TV1102 demonstrated a highly significant effect on disease activity in patients with multiple sclerosis.
    • Interim data from an ongoing Phase 1 study showing that iCo-007 appears to be well tolerated in patients with diffuse diabetic macular edema.

    Isis broadened its pipeline with the addition of new drugs that Isis' partners are developing including,

    • An antisense drug that targets PCSK9, BMS-PCSK9Rx.
    • An antisense drug for the local treatment of fibrosis and scarring, EXC001.
    • A novel aminoglycoside drug, ACHN-490, which Achaogen is developing to treat bacterial infections.

    Isis' pipeline matured with the initiation of clinical trials in multiple drugs including,

    • ISIS-CRPRx to treat coronary artery disease, inflammation and end-stage renal disease.
    • ISIS-SGLT2Rx to treat type 2 diabetes.
    • AIR645 to treat asthma.
    • LY2181308 to treat cancer.

    Corporate Highlights

    Isis continued to execute its successful business strategy by monetizing key assets with partners to continue the development and commercialization of the assets with
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    SOURCE Isis Pharmaceuticals, Inc.
    Copyright©2009 PR Newswire.
    All rights reserved

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