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Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008
Date:2/25/2009

operations for the year ended December 31, 2008 were $107.0 million compared to $83.0 million for 2007. The higher expenses in 2008 compared to 2007 were primarily due to the expansion of the Company's clinical development programs, including additional expenses associated with the development of mipomersen, the lead drug in Isis' cardiovascular franchise, increased activity levels related to Isis' planned investment to fill its pipeline, increased expenses to manufacture drug supplies for Isis' corporate partners and its internal drug development programs, and expenses for Regulus, which began operations in September 2007. On a GAAP basis, Isis' operating expenses from continuing operations for the year ended December 31, 2008 were $120.3 million compared to $91.3 million for 2007, including non-cash compensation expense related to stock options of $13.3 million and $8.3 million, respectively. Going forward, Isis' operating expenses will increase modestly as Isis continues the development of mipomersen, as Regulus continues to build its core team, and as Isis expands its research and development efforts in different disease areas.

Net Loss from Continuing Operations

Net loss from continuing operations for the year ended December 31, 2008 was $3.6 million compared to a net loss of $5.0 million in 2007. In 2007, Isis recognized a $23.2 million benefit in the loss attributed to the noncontrolling interest in Symphony GenIsis. Excluding this item, the improvement in Isis' net loss from continuing operations was primarily driven by the improvement in net operating results, illustrating Isis' progression towards sustained profitability.

Net Loss from Discontinued Operations

The net loss from discontinued operations represents the operating results of Ibis that are presented separately in Isis' financial statements as a result of the sale of Ibis to AMI in January 2009. Th
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SOURCE Isis Pharmaceuticals, Inc.
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