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Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008
Date:2/25/2009

all prior periods are presented in Isis' financial statements separately as discontinued operations.

The considerable improvement in the Company's pro forma and GAAP operating results was driven primarily by the significant increase in revenue in 2008 from Isis' corporate partnerships. This was offset, in part, by higher expenses associated with the expansion of the Company's programs and, for Isis' GAAP results, an increase in non-cash stock compensation expense reflecting the increase in Isis' stock price over the same periods. Please refer to the reconciliation of pro forma and GAAP measures, which are explained later in this release.

Revenue

Revenue from continuing operations for the year ended December 31, 2008 was $107.2 million compared to $58.3 million in 2007. Isis' revenue nearly doubled in 2008 compared to 2007 as a result of the Company's collaborations including its strategic alliances with Genzyme Corporation (Genzyme), Ortho-McNeil-Janssen Pharmaceuticals Inc. and Bristol-Myers Squibb Company (BMS). Also contributing to the increase was the revenue Regulus Therapeutics (Regulus) earned from its strategic alliance with GlaxoSmithKline (GSK). Since these strategic alliances include ongoing research and development activities, Isis will continue to recognize significant amounts of revenue from these collaborations in the future. In addition to revenue from its pharmaceutical alliances, Isis' satellite company strategy has made significant contributions to Isis' revenue. For example, in 2007, Isis earned $26.5 million of sublicensing revenue from Alnylam Pharmaceuticals, Inc. (Alnylam). In 2008, Isis continued to earn substantial revenue from its satellite companies, including $6.1 million in sublicensing revenue from Alnylam and Antisense Therapeutics Limited (ATL).

Operating Expenses

On a pro forma basis, operating expenses from continuing
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SOURCE Isis Pharmaceuticals, Inc.
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