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Isis Reports Strong Financial Results and Highlights for Fiscal Year 2008
Date:2/25/2009

Pro forma net income (loss) $(5,410) $(4,255) $3,100 $(1,084)

Reconciliation of GAAP to Pro Forma Basis

As illustrated in the Selected Financial Information in this press release, pro forma operating expenses, pro forma loss from operations and pro forma net income (loss) were adjusted from GAAP to exclude compensation expense related to stock options, which are non-cash. Isis has regularly reported non-GAAP measures for operating expenses and loss from operations as pro forma results. These measures are provided as supplementary information and are not a substitute for financial measures calculated in accordance with GAAP. Isis reports these pro forma results to better enable financial statement users to assess and compare its historical performance and project its future operating results and cash flows. Further, the presentation of Isis' pro forma results is consistent with how Isis' management internally evaluates the performance of its operations.



                          Regulus Therapeutics
                        Statements of Operations
                             (In Thousands)

                                 Three months ended,     Years ended,
                                     December 31,        December 31,
                                   2008        2007     2008      2007
                                     (unaudited)         (unaudited)

    Revenue:
      Research and development
       revenue under
       collaborative agreements    $681        $78     $2,110     $119
    Total revenue                   681         78      2,110      119

    Expenses:
      Research and
       development                2,738        734      8,030      833
      General and
       administrative               673        161      2,001      191
    Total operating
     expenses                     3,411        895     10,031    1,02
'/>"/>
SOURCE Isis Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
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