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Isis Reports Financial Results and Highlights for Fiscal year 2007
Date:3/13/2008

sation expense related to stock options, operating expenses for Ibis were $6.3 million and $20.5 million for the quarter and year ended December 31, 2007, respectively, compared to $4.9 million and $15.6 million for the same periods in 2006. The increase in operating expenses primarily reflects an increase in sales, marketing and manufacturing costs necessary to support the early commercialization phase of the Ibis T5000 Biosensor System. Ibis generated a loss from operations, excluding non-cash compensation expense related to stock options, of $3.2 million and $9.2 million for the quarter and year ended December 31, 2007, respectively, compared to $3.0 million and $6.0 million for the same periods in 2006.

Regulus Therapeutics LLC

In September 2007, Isis and Alnylam formed Regulus, a joint venture focused on the discovery, development, and commercialization of microRNA therapeutics. Under accounting rules, Isis is considered the primary beneficiary of Regulus and consolidates the financial results of Regulus. As a result, Isis' consolidated financial statements include the $10 million of cash contributed by Alnylam to fund Regulus. Isis' consolidated financial statements also include a line item called "Noncontrolling Interest in Regulus Therapeutics LLC." On Isis' Consolidated Balance Sheet, this line reflects Alnylam's minority ownership of Regulus' equity. As the joint venture progresses, this line item will be reduced by Alnylam's share of Regulus' net losses, which were $629,000 in 2007, until the balance becomes zero. The reductions to the Noncontrolling Interest in Regulus will be reflected in Isis' Consolidated Statement of Operations using a similar line item and will provide a positive adjustment to Isis' net income (loss) equal to Alnylam's share of Regulus' losses.

Early Retirement of Debt

In January 2007, Isis issued $162.5 million of 2 5/8% convertible subordinated notes due 2027. Using a portion of the net proceeds from th
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SOURCE Isis Pharmaceuticals, Inc.
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